『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Chinen Ichiro (日) (読)
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学籍番号 (推奨):
[継承]
2.島袋 充生
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学籍番号 (推奨):
[継承]
3. (英) Yamakawa Ken (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Higa Namio (日) (読)
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[継承]
5. (英) Matsuzaki Toshihiro (日) (読)
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6. (英) Noguchi Katsuhiko (日) (読)
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7. (英) Ueda Shinichiro (日) (読)
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8. (英) Sakanashi Matao (日) (読)
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9. (英) Takasu Nobuyuki (日) (読)
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題名 (必須): (英) Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Vascular endothelial dysfunction has been demonstrated in obesity, but the molecular basis for this link has not been clarified. We examined the role of free fatty acids (FFA) on vascular reactivity in the obese fa/fa Zucker diabetic fatty (ZDF) rat. Addition of acetylcholine produced a dose-dependent relaxation in aortic rings of ZDF and lean +/+ rats, but the ED(50) value was higher in ZDF (-6.80 +/- 0.05 vs. -7.11 +/- 0.05 log(10) mol/liter, P = 0.033). A 2-wk treatment with a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, pitavastatin (3 mg/kg/d) or a reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, apocynin (5 mmol/liter in drinking water), improved the response in ZDF (ED(50), -7.16 +/- 0.03 and -7.14 +/- 0.05 log(10) mol/liter, P = 0.008 and P = 0.015 vs. vehicle, respectively). Vasodilator response to sodium nitroprusside was identical between ZDF and +/+ rats. Vascular reactive oxygen species (ROS) levels and NADPH oxidase activity in aorta were increased in ZDF rats but were decreased by pitavastatin. In in vitro cell culture, intracellular ROS signal and NADPH oxidase subunit mRNA were increased by palmitate, but this palmitate-induced ROS production was inhibited by NADPH oxidase inhibitor or pitavastatin. In conclusion, FFA-induced NADPH oxidase subunit overexpression and ROS production could be involved in the endothelial dysfunction seen in obese ZDF rats, and this could be protected by pitavastatin or NADPH oxidase inhibitors.  (日)    [継承]
キーワード (推奨): 1. (英) Acetophenones (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cells, Cultured (日) (読) [継承]
4. (英) Diabetes Mellitus, Type 2 (日) (読) [継承]
5. (英) Dyslipidemias (日) (読) [継承]
6. (英) Endothelium, Vascular (日) (読) [継承]
7. (英) Enzyme Inhibitors (日) (読) [継承]
8. (英) Fatty Acids, Nonesterified (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10.高血圧 (hypertension) [継承]
11. (英) Intra-Abdominal Fat (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) NADPH Oxidase (日) (読) [継承]
14. (英) Nitric Oxide Synthase Type III (日) (読) [継承]
15.肥満症 (obesity) [継承]
16.酸化ストレス (oxidative stress) [継承]
17. (英) Quinolines (日) (読) [継承]
18. (英) Rats (日) (読) [継承]
19. (英) Rats, Zucker (日) (読) [継承]
20.活性酸素 (reactive oxygen species/->キーワード[活性酸素種]) [継承]
21. (英) Umbilical Veins (日) (読) [継承]
22. (英) Vasoconstriction (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 148 [継承]
(必須): 1 [継承]
(必須): 160 165 [継承]
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年月日 (必須): 西暦 2007年 1月 初日 (平成 19年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2006-1132    (→Scopusで検索) [継承]
PMID (任意): 17023526    (→Scopusで検索) [継承]
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WOS (任意):
Scopus (任意): 2-s2.0-33845875499 [継承]
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備考 (任意): 1.(英) Affiliation: Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa 903-0215, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Ichiro Chinen, Michio Shimabukuro, Ken Yamakawa, Namio Higa, Toshihiro Matsuzaki, Katsuhiko Noguchi, Shinichiro Ueda, Matao Sakanashi and Nobuyuki Takasu : Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats., Endocrinology, Vol.148, No.1, 160-165, 2007.
欧文冊子 ● Ichiro Chinen, Michio Shimabukuro, Ken Yamakawa, Namio Higa, Toshihiro Matsuzaki, Katsuhiko Noguchi, Shinichiro Ueda, Matao Sakanashi and Nobuyuki Takasu : Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats., Endocrinology, Vol.148, No.1, 160-165, 2007.

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