『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Watanabe Hitoshi (日) (読)
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[継承]
2. (英) Akasaka Daisuke (日) (読)
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[継承]
3. (英) Ogasawara Hideki (日) (読)
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[継承]
4. (英) Sato Kan (日) (読)
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[継承]
5.三宅 雅人 ([徳島大学.先端酵素学研究所.重点研究部門])
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学籍番号 (推奨):
[継承]
6. (英) Saito Kazuki (日) (読)
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[継承]
7. (英) Takahashi Yu (日) (読)
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[継承]
8. (英) Kanaya Takashi (日) (読)
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[継承]
9. (英) Takakura Ikuro (日) (読)
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[継承]
10. (英) Hondo Tetsuya (日) (読)
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[継承]
11. (英) Chao Guozheng (日) (読)
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[継承]
12. (英) Rose Michael T (日) (読)
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[継承]
13. (英) Ohwada Shyuichi (日) (読)
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[継承]
14. (英) Watanabe Kouichi (日) (読)
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15. (英) Yamaguchi Takahiro (日) (読)
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[継承]
16. (英) Aso Hisashi (日) (読)
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[継承]
題名 (必須): (英) Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Serotonin is synthesized by two distinct tryptophan hydroxylases, one in the brain and one in the periphery. The latter is known to be unable to cross the blood-brain barrier. These two serotonin systems have apparently independent functions, although the functions of peripheral serotonin have yet to be fully elucidated. In this study, we have investigated the physiological effect of peripheral serotonin on the concentrations of metabolites in the circulation and in the liver. After fasting, mice were ip injected with 1 mg serotonin. The plasma glucose concentration was significantly elevated between 60 and 270 min after the injection. In contrast, plasma triglyceride, cholesterol, and nonesterified fatty acid concentrations were decreased. The hepatic glycogen synthesis and concentrations were significantly higher at 240 min. At the same time, the hepatic triglyceride content was significantly lower than the basal levels noted before the serotonin injection, whereas the hepatic cholesterol content was significantly higher by 60 min after the injection. Furthermore, serotonin stimulated the contraction of the gallbladder and the excretion of bile. After the serotonin injection, there was a significant induction of apical sodium-dependent bile acid transporter expression, resulting in a decrease in the concentration of bile acids in the feces. Additionally, data are presented to show that the functions of serotonin are mediated through diverse serotonin receptor subtypes. These data indicate that peripheral serotonin accelerates the metabolism of lipid by increasing the concentration of bile acids in circulation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Bile Acids and Salts (日) (読) [継承]
3. (英) Dose-Response Relationship, Drug (日) (読) [継承]
4. (英) Fasting (日) (読) [継承]
5. (英) Gallbladder (日) (読) [継承]
6. (英) Glucose (日) (読) [継承]
7. (英) Glycogen (日) (読) [継承]
8. (英) Ileum (日) (読) [継承]
9. (英) Injections, Intraperitoneal (日) (読) [継承]
10. (英) Insulin (日) (読) [継承]
11. (英) Lipid Metabolism (日) (読) [継承]
12. (英) Liver (日) (読) [継承]
13. (英) Male (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Inbred C57BL (日) (読) [継承]
16. (英) Serotonin (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 151 [継承]
(必須): 10 [継承]
(必須): 4776 4786 [継承]
都市 (任意):
年月日 (必須): 西暦 2010年 8月 4日 (平成 22年 8月 4日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2009-1349    (→Scopusで検索) [継承]
PMID (任意): 20685881    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Cellular Biology Laboratory, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hitoshi Watanabe, Daisuke Akasaka, Hideki Ogasawara, Kan Sato, Masato Miyake, Kazuki Saito, Yu Takahashi, Takashi Kanaya, Ikuro Takakura, Tetsuya Hondo, Guozheng Chao, T Michael Rose, Shyuichi Ohwada, Kouichi Watanabe, Takahiro Yamaguchi and Hisashi Aso : Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover., Endocrinology, Vol.151, No.10, 4776-4786, 2010.
欧文冊子 ● Hitoshi Watanabe, Daisuke Akasaka, Hideki Ogasawara, Kan Sato, Masato Miyake, Kazuki Saito, Yu Takahashi, Takashi Kanaya, Ikuro Takakura, Tetsuya Hondo, Guozheng Chao, T Michael Rose, Shyuichi Ohwada, Kouichi Watanabe, Takahiro Yamaguchi and Hisashi Aso : Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover., Endocrinology, Vol.151, No.10, 4776-4786, 2010.

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