『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=227348)

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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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著者 (必須): 1.三宅 雅人 ([徳島大学.先端酵素学研究所.重点研究部門])
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2. (英) Hayashi Shinichiro (日) (読)
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3. (英) Taketa Yoshikazu (日) (読)
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4. (英) Iwasaki Shunsuke (日) (読)
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5. (英) Watanabe Kouichi (日) (読)
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6. (英) Ohwada Shyuich (日) (読)
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7. (英) Aso Hisashi (日) (読)
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8. (英) Yamaguchi Takahiro (日) (読)
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題名 (必須): (英) Myostatin down-regulates the IGF-2 expression via ALK-Smad signaling during myogenesis in cattle.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Myostatin (MSTN) is a negative regulator during muscle differentiation, whereas insulin-like growth factors (IGFs) are essential for muscle development. MSTN and IGFs act oppositely during myogenesis, but there is little information on the mutual relationship of MSTN and IGFs. The present study was conducted to examine whether MSTN affects IGF expression during early myogenesis in cattle. IGF-1 mRNA was similarly expressed in M. longissimus thoracis of double-muscled (DM) and normal (NM) Japanese shorthorn cattle. IGF-2 mRNA expression was consistently higher in the normal and regenerating muscle of DM cattle than those of NM cattle. When myoblasts were isolated from regenerating M. longissimus thoracis, IGF-2 mRNA expression showed a significant increase in differentiating DM derived myoblasts (DM-myoblasts) as compared with differentiating NM derived myoblasts (NM-myoblasts). An addition of recombinant mouse myostatin (rMSTN) to myoblast cultures attenuated IGF-2 mRNA expression and decreased myotube formation, but did not effect IGF-1 mRNA expression. An activin-like kinase (ALK) inhibitor, SB431542, mediates MSTN action, suppressed the translocation of Smad2/3 into the nucleus in DM-myoblasts, and restored the attenuated IGF-2 mRNA expression and the decreased myotube formation induced by rMSTN in myoblast cultures. The findings indicate that MSTN may negatively regulate myoblast differentiation by suppressing IGF-2 expression via ALK-Smad signaling.  (日)    [継承]
キーワード (推奨): 1. (英) Activin Receptors (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cattle (日) (読) [継承]
4. (英) Down-Regulation (日) (読) [継承]
5. (英) Insulin-Like Growth Factor II (日) (読) [継承]
6. (英) Muscle Development (日) (読) [継承]
7. (英) Myostatin (日) (読) [継承]
8. (英) Signal Transduction (日) (読) [継承]
9. (英) Smad Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Animal Science Journal (日本畜産学会)
(pISSN: 1344-3941, eISSN: 1740-0929)

ISSN (任意): 1740-0929
ISSN: 1344-3941 (pISSN: 1344-3941, eISSN: 1740-0929)
Title: Animal science journal = Nihon chikusan Gakkaiho
Title(ISO): Anim Sci J
Supplier: Japanese Society of Animal Science
Publisher: Wiley Publishing
 (NLM Catalog  (医中誌Web  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 223 229 [継承]
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年月日 (必須): 西暦 2010年 4月 初日 (平成 22年 4月 初日) [継承]
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DOI (任意): 10.1111/j.1740-0929.2009.00725.x    (→Scopusで検索) [継承]
PMID (任意): 20438504    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Animal Biology, Graduate School of Agricultural Science, Tohoku University, Aoba, Sendai, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Masato Miyake, Shinichiro Hayashi, Yoshikazu Taketa, Shunsuke Iwasaki, Kouichi Watanabe, Shyuich Ohwada, Hisashi Aso and Takahiro Yamaguchi : Myostatin down-regulates the IGF-2 expression via ALK-Smad signaling during myogenesis in cattle., Animal Science Journal, Vol.81, No.2, 223-229, 2010.
欧文冊子 ● Masato Miyake, Shinichiro Hayashi, Yoshikazu Taketa, Shunsuke Iwasaki, Kouichi Watanabe, Shyuich Ohwada, Hisashi Aso and Takahiro Yamaguchi : Myostatin down-regulates the IGF-2 expression via ALK-Smad signaling during myogenesis in cattle., Animal Science Journal, Vol.81, No.2, 223-229, 2010.

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