| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Muroya Susumu (日) (読)
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| 2. | (英) Watanabe Kouichi (日) (読)
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| 3. | (英) Hayashi Shinichiro (日) (読)
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| 4. | 三宅 雅人 ([徳島大学.先端酵素学研究所.重点研究部門])
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| 5. | (英) Konashi Shigeru (日) (読)
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| 6. | (英) Sato Youichi (日) (読)
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| 7. | (英) Takahashi Manabu (日) (読)
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| 8. | (英) Kawahata Shigeki (日) (読)
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| 9. | (英) Yoshikawa Yoshisato (日) (読)
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| 10. | (英) Aso Hisashi (日) (読)
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| 11. | (英) Chikuni Koichi (日) (読)
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| 12. | (英) Yamaguchi Takahiro (日) (読)
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| ○題名 (必須): | □ | (英) Muscle type-specific effect of myostatin deficiency on myogenic regulatory factor expression in adult double-muscled Japanese Shorthorn cattle. (日)
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| ○要約 (任意): | □ | (英) To clarify muscle type-specific effect of myostatin on myogenic regulatory factors (MRFs), we examined mRNA expression of MRFs in five skeletal muscles of normal (NM) and myostatin-deficient double-muscled (DM) adult Japanese Shorthorn cattle by quantitative reverse-transcribed PCR. Among the four MRFs, namely, Myf5, MyoD, myogenin, and MRF4, MyoD expression was different among the muscles of the DM cattle (P < 0.01) but not of the NM cattle. Meanwhile, MyoD expression was significantly elevated only in masseter (MS) muscle in the DM cattle due to the myostatin deficiency (P < 0.05). Myf5 and MRF4 expression in semitendinosus (ST) was higher in the DM than in the NM cattle (P < 0.05). According to analysis of myosin heavy chain (MyHC) isoform expression, more MyHC-2x and -2a and less -slow isoforms were expressed in the longissimus and ST muscles compared to the MS muscle in both cattle (P < 0.05), but no significant difference in MyHC expression was observed between the NM and DM cattle. Taken together, myostatin has influences on Myf5 and MRF4 expression in faster-type muscles and on MyoD expression in slower-type muscles, suggesting a possible muscle type-specific effect of myostatin in skeletal muscle growth and maintenance. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cattle (日) (読)
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| 3. | (英) Muscle, Skeletal (日) (読)
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| 4. | (英) Myogenic Regulatory Factors (日) (読)
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| 5. | (英) Myostatin (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Animal Science Journal (日本畜産学会)
(pISSN: 1344-3941, eISSN: 1740-0929)
| ○ISSN (任意): | □ | 1740-0929
ISSN: 1344-3941
(pISSN: 1344-3941, eISSN: 1740-0929) Title: Animal science journal = Nihon chikusan GakkaihoTitle(ISO): Anim Sci JSupplier: Japanese Society of Animal SciencePublisher: Wiley Publishing (NLM Catalog)
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| ○巻 (必須): | □ | 80
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 678 685
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2009年 12月 初日 (平成 21年 12月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/j.1740-0929.2009.00684.x (→Scopusで検索)
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| ○PMID (任意): | □ | 20163658 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Affiliation: Meat Protein Research Team, National Institute of Livestock and Grassland Science, Tsukuba, Ibaraki, Japan. muros@affrc.go.jp (日)
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| 2. | (英) PublicationType: Journal Article (日)
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| 3. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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