| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Nagai Yasuhiro (日) (読)
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| 2. | (英) Ogasawara Hideki (日) (読)
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| 3. | (英) Taketa Yoshikazu (日) (読)
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| 4. | (英) Aso Hisashi (日) (読)
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| 5. | (英) Kanaya Takashi (日) (読)
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| 6. | 三宅 雅人 ([徳島大学.先端酵素学研究所.重点研究部門])
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| 7. | (英) Watanabe Kouichi (日) (読)
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| 8. | (英) Ohwada Shyuichi (日) (読)
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| 9. | (英) Muneta Yoshihiro (日) (読)
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| 10. | (英) Yamaguchi Takahiro (日) (読)
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| ○題名 (必須): | □ | (英) Expression of inflammatory-related factors in porcine anterior pituitary-derived cell line. (日)
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| ○要約 (任意): | □ | (英) Recent studies have shown that undifferentiated stem cells act as immunomodulators. To investigate the immunomodulatory function of the progenitor cells of the anterior pituitary gland, we attempted to establish a stem/progenitor cell line from the porcine anterior pituitary gland, and to detail its inflammatory cytokine expression. A cloned cell line from the porcine anterior pituitary gland was established and was designated as the porcine anterior pituitary-derived cell line (PAPC). PAPC expressed the mRNA of Nanog and Oct-4, and showed positive immunoreactivity for beta-catenin and Hes1 in its nucleus. PAPC grew stably by repeated passage and rapidly in the EGF and bFGF containing medium. RT-PCR showed that PAPC expressed mRNA of IL-1alpha, IL-6, IL-12, IL-15, IL-18 and TLR4. PAPC expressed S100alpha and IL-18 protein, which was localized in the marginal epithelial cells of Rathke's pouch. These results suggest that PAPC is a stem/progenitor cell and may regulate anterior pituitary cell function through an immuno-endocrine pathway. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cytokines (日) (読)
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| 3. | (英) Female (日) (読)
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| 4. | (英) Immunohistochemistry (日) (読)
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| 5. | (英) Inflammation (日) (読)
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| 6. | (英) Pituitary Gland, Anterior (日) (読)
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| 7. | (英) RNA, Messenger (日) (読)
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| 8. | (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読)
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| 9. | (英) Stem Cells (日) (読)
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| 10. | (英) Swine (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Veterinary Immunology and Immunopathology ([Elsevier])
(pISSN: 0165-2427, eISSN: 1873-2534)
| ○ISSN (任意): | □ | 0165-2427
ISSN: 0165-2427
(pISSN: 0165-2427, eISSN: 1873-2534) Title: Veterinary immunology and immunopathologyTitle(ISO): Vet Immunol ImmunopatholPublisher: Elsevier BV (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 124
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| ○号 (必須): | □ | 3-4
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| ○頁 (必須): | □ | 201 208
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 3月 27日 (平成 20年 3月 27日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.vetimm.2008.03.007 (→Scopusで検索)
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| ○PMID (任意): | □ | 18440649 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000258638500001
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| ○備考 (任意): | 1. | (英) Affiliation: Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, 981-8555 Sendai, Japan. (日)
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| 2. | (英) PublicationType: Journal Article (日)
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