| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Hashizume Shunji (日) (読)
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| 2. | 赤池 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
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| 3. | 東 博之
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| 4. | (英) Ishikawa Kazue (日) (読)
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| 5. | 吉田 守美子
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| 6. | 上田 由佳
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| 7. | 八木 秀介 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.地域・家庭医療学])
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| 8. | 池田 康将 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学]/[徳島大学.医学部.医学科.病態情報医学講座.薬理学分野]/[徳島大学.医学研究科.医学専攻.病態情報医学講座]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学])
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| 9. | 岩瀬 俊
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| 10. | 粟飯原 賢一 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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| 11. | 安倍 正博
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| 12. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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| 13. | 松本 俊夫
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| ○題名 (必須): | □ | (英) Activation of peroxisome proliferator-activated receptor α in megakaryocytes reduces platelet-derived growth factor-BB in platelets. (日)
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| ○要約 (任意): | □ | (英) Platelet-derived growth factor (PDGF)-BB plays a crucial role in atherosclerosis and vascular remodeling by promoting the migration and proliferation of vascular smooth muscle cells. The objective of this study was to clarify the pleiotropic effect of peroxisome proliferator-activated receptor α (PPARα) activators on PDGF-BB expression in megakaryocytes and platelets. The expression of PPARα in a human erythroleukemia (HEL) cells was clearly detected by reverse transcriptase-PCR and immunofluorescence microscopy. The expression level of PPARα in HEL cells was unchanged regardless of differentiation into megakaryocytic cells by treatment with phorbol 12-myristate 13 acetate (TPA). The TPA-induced expression of PDGF-B mRNA and PDGF-BB protein levels in culture media was significantly decreased by treatment with PPARα activators, Wy14643 and fenofibric acid, in a dose-dependent manner. PDGF-BB expression induced by inflammatory cytokines, including interleukin-1β or interleukin-6, was also significantly suppressed by treatment with PPARα activators. Immunohistochemistry of human bone marrow showed the expression of PPARα in both the nucleus and cytoplasm of megakaryocytes. In addition, PDGF-BB levels in platelets were significantly decreased from 1,800±870 to 1,470±840 pg/10(5) platelets (mean±SD, p<0.05) by treatment with 300 mg fenofibrate once daily for 4 weeks in 13 patients with dyslipidemia. Activation of PPARα in megakaryocytes reduces PDGF-BB expression in platelets. PPARα activators may exert vasculo-protective action through suppression of PDGF-BB production in a megakaryocyte/platelet pathway. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Blood Platelets (日) (読)
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| 3. | 細胞分化 (cell differentiation)
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| 4. | (英) Cell Line, Tumor (日) (読)
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| 5. | (英) Dyslipidemias (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Fenofibrate (日) (読)
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| 8. | 遺伝子発現 (gene expression)
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| 9. | (英) Humans (日) (読)
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| 10. | 免疫組織化学 (immunohistochemistry)
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| 11. | (英) Lipids (日) (読)
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| 12. | (英) Male (日) (読)
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| 13. | (英) Megakaryocytes (日) (読)
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| 14. | (英) Middle Aged (日) (読)
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| 15. | (英) PPAR alpha (日) (読)
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| 16. | (英) Platelet-Derived Growth Factor (日) (読)
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| 17. | (英) Pyrimidines (日) (読)
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| 18. | (英) RNA, Messenger (日) (読)
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| 19. | (英) Tetradecanoylphorbol Acetate (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Atherosclerosis and Thrombosis (日本動脈硬化学会)
(pISSN: 1340-3478, eISSN: 1880-3873)
| ○ISSN (任意): | □ | 1880-3873
ISSN: 1340-3478
(pISSN: 1340-3478, eISSN: 1880-3873) Title: Journal of atherosclerosis and thrombosisTitle(ISO): J Atheroscler ThrombSupplier: 一般社団法人 日本動脈硬化学会Publisher: Japan Atherosclerosis Society (NLM Catalog)
(医中誌Web)
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(Scopus)
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(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 18
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 138 147
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 0月 初日 (平成 23年 0月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.5551/jat.5868 (→Scopusで検索)
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| ○PMID (任意): | □ | 21060209 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000287818500008
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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