『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=226137EID:226137, Map:0, LastModified:2021年3月18日(木) 11:09:53, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院医歯薬学研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.井本 逸勢
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Tsuda Hitoshi (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Hirasawa Akira (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Miura Masahiko (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Sakamoto Masaru (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Hirohashi Setsuo (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Inazawa Johji (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Inhibition of, or increased resistance to, apoptosis is a common property of cancer cells. This means that a constitutive activation of antiapoptotic molecules via genetic or epigenetic mechanisms, including gene amplification, may well be involved in carcinogenesis. Recently we reported that cIAP1, an inhibitor of apoptosis, is overexpressed through 11q22 amplification in cell lines derived from esophageal squamous cell carcinomas and is associated with resistance of esophageal squamous cell carcinomas to drug-induced apoptosis (I. Imoto et al. Cancer Res., 61: 6629-6634, 2001). Because amplification of 11q22 has been implicated in other malignancies also, including cervical squamous cell carcinomas (CSCCs), we attempted to correlate amplification and overexpression of cIAP1 with radiation sensitivity in CSCC-derived cell lines and primary CSCC tumors. In the nine cell lines we examined, two showed amplification and consistent overexpression of cIAP1, as well as significant resistance to radiation-induced cell death as compared with lines showing no cIAP1 amplification. Immunohistochemical analysis of 70 primary CSCCs from patients treated only with radiotherapy demonstrated that both overall survival and local recurrence-free survival was significantly poorer among patients with tumors showing high levels of nuclear cIAP1 staining than among patients whose tumors revealed little or no nuclear cIAP1. Multivariate analysis showed nuclear cIAP1 staining to be an independent predictive factor for local recurrence-free survival after radiotherapy among patients with CSCC. These findings demonstrate that cIAP1 may play an important role in the development/progression of this disease and that cIAP1 could be a novel predictive marker for resistance to radiotherapy in individual CSCC patients.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Aged, 80 and over (日) (読) [継承]
4. (英) Carcinoma, Squamous Cell (日) (読) [継承]
5.細胞死 (cell death) [継承]
6. (英) Chromosomes, Human, Pair 11 (日) (読) [継承]
7.女性 (female) [継承]
8. (英) Gene Amplification (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10.免疫組織化学 (immunohistochemistry) [継承]
11. (英) Inhibitor of Apoptosis Proteins (日) (読) [継承]
12. (英) Middle Aged (日) (読) [継承]
13. (英) Neoplasm Staging (日) (読) [継承]
14. (英) Protein Biosynthesis (日) (読) [継承]
15. (英) Proteins (日) (読) [継承]
16. (英) Radiation Tolerance (日) (読) [継承]
17. (英) Survival Rate (日) (読) [継承]
18. (英) Tumor Cells, Cultured (日) (読) [継承]
19. (英) Uterine Cervical Neoplasms (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cancer Research (American Assotiation for Cancer Research)
(pISSN: 0008-5472, eISSN: 1538-7445)

ISSN (任意): 0008-5472
ISSN: 0008-5472 (pISSN: 0008-5472, eISSN: 1538-7445)
Title: Cancer research
Title(ISO): Cancer Res
Publisher: American Association for Cancer Research
 (NLM Catalog  (Scopus  (Scopus  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 62 [継承]
(必須): 17 [継承]
(必須): 4860 4866 [継承]
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年月日 (必須): 西暦 2002年 9月 1日 (平成 14年 9月 1日) [継承]
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PMID (任意): 12208731    (→Scopusで検索) [継承]
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WOS (任意): 000177897200004 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical & Dental University, Tokyo 113-8510, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Issei Imoto, Hitoshi Tsuda, Akira Hirasawa, Masahiko Miura, Masaru Sakamoto, Setsuo Hirohashi and Johji Inazawa : Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy., Cancer Research, Vol.62, No.17, 4860-4866, 2002.
欧文冊子 ● Issei Imoto, Hitoshi Tsuda, Akira Hirasawa, Masahiko Miura, Masaru Sakamoto, Setsuo Hirohashi and Johji Inazawa : Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy., Cancer Research, Vol.62, No.17, 4860-4866, 2002.

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