『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kuroda Hiroshi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Moritake Hiroshi (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Sawada Kazumi (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Kuwahara Yasumichi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5.井本 逸勢
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[継承]
6. (英) Inazawa Johji (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Sugimoto Tohru (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 and p16.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Malignant rhabdoid tumors (MRT) of the liver are rare. A few liver MRT cell lines have been established but none has been characterized in detail. Here we describe a new MRT cell line from the liver, which is designated MP-MRT-AN, and describe it in detail. Immunohistochemical assays detected the expression of vimentin and cytokeratin but they were negative for neurofilament, desmin, alpha-smooth muscle actin, alpha-sarcomeric actin, and smooth muscle myosin heavy chains SM1 and SM2. RT-PCR assays revealed that this cell line did not express smooth muscle myosin heavy chain isoforms or MyoD1. No aberration was identified in 22q by G-banded analysis; however, the hSNF5/INI1 gene, a suppressor gene of MRT that maps to 22q11.2, was homozygously deleted from exons 1 to 5 in this cell line. Furthermore, the expression of another tumor suppressor gene, p16 (CDKN2A), was not detected by RT-PCR. This raises the possibility that the aggressive phenotype of malignant rhabdoid tumors is caused by the loss of two or more tumor suppressor genes.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Line, Tumor (日) (読) [継承]
3. (英) Chromosomal Proteins, Non-Histone (日) (読) [継承]
4. (英) Chromosome Banding (日) (読) [継承]
5. (英) Chromosome Mapping (日) (読) [継承]
6. (英) Chromosomes, Human, Pair 22 (日) (読) [継承]
7. (英) DNA-Binding Proteins (日) (読) [継承]
8.女性 (female) [継承]
9. (英) Gene Deletion (日) (読) [継承]
10. (英) Genes, Tumor Suppressor (日) (読) [継承]
11. (英) Genes, p16 (日) (読) [継承]
12. (英) Homozygote (日) (読) [継承]
13. (英) Humans (日) (読) [継承]
14.免疫組織化学 (immunohistochemistry) [継承]
15.小児 (infant) [継承]
16. (英) Keratins (日) (読) [継承]
17. (英) Liver Neoplasms (日) (読) [継承]
18. (英) Mice (日) (読) [継承]
19. (英) Mice, Nude (日) (読) [継承]
20. (英) Neoplasm Transplantation (日) (読) [継承]
21. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
22. (英) Rhabdoid Tumor (日) (読) [継承]
23. (英) Transcription Factors (日) (読) [継承]
24. (英) Vimentin (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cancer Genetics and Cytogenetics ([Elsevier])
(pISSN: 0165-4608, eISSN: 1873-4456)

ISSN (任意): 0165-4608
ISSN: 0165-4608 (pISSN: 0165-4608, eISSN: 1873-4456)
Title: Cancer genetics and cytogenetics
Title(ISO): Cancer Genet Cytogenet
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 158 [継承]
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(必須): 172 179 [継承]
都市 (任意):
年月日 (必須): 西暦 2005年 4月 15日 (平成 17年 4月 15日) [継承]
URL (任意):
DOI (任意): 10.1016/j.cancergencyto.2004.08.032    (→Scopusで検索) [継承]
PMID (任意): 15796965    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-15744394607 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Pediatrics, Kyoto City Hospital, Kyoto, 1-2 Higashitakada-cho, Mibu, Nakagyo-ku, Kyoto 604-8845, Japan. hkuroda@hosp.city.kyoto.jp  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Hiroshi Kuroda, Hiroshi Moritake, Kazumi Sawada, Yasumichi Kuwahara, Issei Imoto, Johji Inazawa and Tohru Sugimoto : Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 and p16., Cancer Genetics and Cytogenetics, Vol.158, No.2, 172-179, 2005.
欧文冊子 ● Hiroshi Kuroda, Hiroshi Moritake, Kazumi Sawada, Yasumichi Kuwahara, Issei Imoto, Johji Inazawa and Tohru Sugimoto : Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 and p16., Cancer Genetics and Cytogenetics, Vol.158, No.2, 172-179, 2005.

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