『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Tanimoto Takao (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Tsuda Hitoshi (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Imazeki Nobuo (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Ohno Yoshihiro (日) (読)
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学籍番号 (推奨):
[継承]
5.井本 逸勢
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学籍番号 (推奨):
[継承]
6. (英) Inazawa Johji (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Matsubara Osamu (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas.  (日)    [継承]
副題 (任意):
要約 (任意): (英) cIAP-1, an apoptosis inhibiting protein, has been suggested to play important roles in the development of cervical and esophageal squamous cell carcinomas (SCCs). In order to clarify the subcellular localization of cIAP-1 and to investigate its clinicopathological significance in head and neck SCCs (HNSCCs), we examined cIAP-1 expression in four oral SCC cell lines by immunocytochemistry and Western blot. Expressions of nuclear and cytoplasmic cIAP-1, caspase-3, and Smac/DIABLO were also examined immunohistochemically in 57 cases of the HNSCCs. cIAP-1 expression was detected in HSC-2, HSC-3, and HSC-4 cells by immunohistochemistry and Western blot. In HSC-2 and HSC-4 cells, cIAP-1 was detected in both the nuclear and cytoplasmic fractions. Nuclear cIAP-1 expression was positive in 17 (30%) of HNSCCs, was correlated with lymph node metastasis (P=0.020) and advanced disease stage (P=0.032), and tended to be correlated with poor patient prognosis (P=0.059). Cytoplasmic cIAP-1 expression showed similar but weaker clinicopathological correlations. Nuclear cIAP-1 expression was inversely correlated with caspase-3 expression, but was correlated with Smac/DIABLO expression. Nuclear cIAP-1 expression appears to be a useful marker for predicting poor patient prognosis in HNSCCs, and may play roles in HNSCCs through the signaling pathway mediated by Smac/DIABLO and caspase-3.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Aged, 80 and over (日) (読) [継承]
4. (英) Blotting, Western (日) (読) [継承]
5. (英) Carcinoma, Squamous Cell (日) (読) [継承]
6. (英) Carrier Proteins (日) (読) [継承]
7. (英) Caspase 3 (日) (読) [継承]
8. (英) Caspases (日) (読) [継承]
9. (英) Cell Nucleus (日) (読) [継承]
10.女性 (female) [継承]
11. (英) Head and Neck Neoplasms (日) (読) [継承]
12. (英) Humans (日) (読) [継承]
13.免疫組織化学 (immunohistochemistry) [継承]
14. (英) Inhibitor of Apoptosis Proteins (日) (読) [継承]
15. (英) Intracellular Signaling Peptides and Proteins (日) (読) [継承]
16. (英) Lymphatic Metastasis (日) (読) [継承]
17.男性 (male) [継承]
18. (英) Middle Aged (日) (読) [継承]
19. (英) Mitochondrial Proteins (日) (読) [継承]
20. (英) Predictive Value of Tests (日) (読) [継承]
21. (英) Prognosis (日) (読) [継承]
22. (英) Proteins (日) (読) [継承]
23.シグナル伝達 (signal transduction) [継承]
24. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cancer Letters (Elsevier Ireland Ltd.)
(pISSN: 0304-3835, eISSN: 1872-7980)

ISSN (任意): 0304-3835
ISSN: 0304-3835 (pISSN: 0304-3835, eISSN: 1872-7980)
Title: Cancer letters
Title(ISO): Cancer Lett
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 224 [継承]
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(必須): 141 151 [継承]
都市 (任意):
年月日 (必須): 西暦 2005年 6月 16日 (平成 17年 6月 16日) [継承]
URL (任意):
DOI (任意): 10.1016/j.canlet.2004.11.049    (→Scopusで検索) [継承]
PMID (任意): 15911110    (→Scopusで検索) [継承]
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指導教員 (推奨):
備考 (任意): 1.(英) Affiliation: Department of Pathology II, National Defense Medical College, Tokorozawa, Saitama, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Takao Tanimoto, Hitoshi Tsuda, Nobuo Imazeki, Yoshihiro Ohno, Issei Imoto, Johji Inazawa and Osamu Matsubara : Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas., Cancer Letters, Vol.224, No.1, 141-151, 2005.
欧文冊子 ● Takao Tanimoto, Hitoshi Tsuda, Nobuo Imazeki, Yoshihiro Ohno, Issei Imoto, Johji Inazawa and Osamu Matsubara : Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas., Cancer Letters, Vol.224, No.1, 141-151, 2005.

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