『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Tanami Hideaki (日) (読)
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[継承]
2. (英) Tsuda Hitoshi (日) (読)
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[継承]
3. (英) Okabe Satoshi (日) (読)
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[継承]
4. (英) Iwai Takehisa (日) (読)
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[継承]
5. (英) Sugihara Kenichi (日) (読)
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6.井本 逸勢
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[継承]
7. (英) Inazawa Johji (日) (読)
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[継承]
題名 (必須): (英) Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The question of whether any genetic differences exist between primary and colorectal cancers (CRCs) and their metastatic foci is controversial. To look for genetic aberrations involved in metastasis of CRCs to the liver, we performed subtractive comparative genomic hybridization (CGH) experiments using paired samples from 20 CRC patients with primary tumors and synchronous or metachronous liver metastases. Relatively frequent gains in DNA copy number were detected at 6p, suggesting the presence of one or more metastasis-related genes in the region. Analysis of 11 CRC cell lines using array-based CGH (CGH-array) revealed one 6p candidate gene, CCND3. Quantitative reverse transcriptase-polymerase chain reaction experiments showed that CCND3 was significantly upregulated in liver-metastatic lesions compared with primary lesions (P<0.0152). In addition, immunohistochemical analysis of 120 primary CRC tumors demonstrated that cyclin D3 expression in the region of rolled edge was significantly associated with total recurrence, especially hematogenous recurrence (P=0.0307). The results implied involvement of cyclin D3 in liver metastasis of CRC, and the data may contribute to the development of a novel therapy or diagnostic agent for this currently intractable disease. Our experiments also confirmed the power of subtractive CGH and CGH-array analysis for identifying cancer-related genes.  (日)    [継承]
キーワード (推奨): 1. (英) Colorectal Neoplasms (日) (読) [継承]
2. (英) Cyclin D3 (日) (読) [継承]
3. (英) Cyclins (日) (読) [継承]
4.女性 (female) [継承]
5. (英) Genome, Human (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7.免疫組織化学 (immunohistochemistry) [継承]
8. (英) Liver Neoplasms (日) (読) [継承]
9.男性 (male) [継承]
10. (英) Middle Aged (日) (読) [継承]
11. (英) Neoplasm Metastasis (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Laboratory Investigation; a Journal of Technical Methods and Pathology (United States and Canadian Academy of Pathology)
(pISSN: 0023-6837, eISSN: 1530-0307)

ISSN (任意): 0023-6837
ISSN: 0023-6837 (pISSN: 0023-6837, eISSN: 1530-0307)
Title: Laboratory investigation; a journal of technical methods and pathology
Title(ISO): Lab Invest
Publisher: Springer Nature
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 85 [継承]
(必須): 9 [継承]
(必須): 1118 1129 [継承]
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年月日 (必須): 西暦 2005年 9月 初日 (平成 17年 9月 初日) [継承]
URL (任意):
DOI (任意): 10.1038/labinvest.3700312    (→Scopusで検索) [継承]
PMID (任意): 15980885    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-27744552327 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov&apos;t  (日)    [継承]

標準的な表示

和文冊子 ● Hideaki Tanami, Hitoshi Tsuda, Satoshi Okabe, Takehisa Iwai, Kenichi Sugihara, Issei Imoto and Johji Inazawa : Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis., Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.85, No.9, 1118-1129, 2005.
欧文冊子 ● Hideaki Tanami, Hitoshi Tsuda, Satoshi Okabe, Takehisa Iwai, Kenichi Sugihara, Issei Imoto and Johji Inazawa : Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis., Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.85, No.9, 1118-1129, 2005.

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