『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=225991EID:225991, Map:0, LastModified:2021年3月19日(金) 13:17:13, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院医歯薬学研究部]], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨): □研究 [継承]
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1. (英) Kumada Kazuki (日) (読)
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2. (英) Yao Ryoji (日) (読)
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3. (英) Kawaguchi Tokuichi (日) (読)
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4. (英) Karasawa Mika (日) (読)
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5. (英) Hoshikawa Yutaka (日) (読)
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6. (英) Ichikawa Koji (日) (読)
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7. (英) Sugitani Yoshinobu (日) (読)
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8.井本 逸勢
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9. (英) Inazawa Johji (日) (読)
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10. (英) Sugawara Minoru (日) (読)
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11. (英) Yanagida Mitsuhiro (日) (読)
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12. (英) Noda Tetsuo (日) (読)
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○題名 (必須): □(英) The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) Separase is an evolutionarily conserved protease that is essential for chromosome segregation and cleaves cohesin Scc1/Rad21, which joins the sister chromatids together. Although mammalian separase also functions in chromosome segregation, our understanding of this process in mammals is still incomplete. We generated separase knockout mice, reporting an essential function for mammalian separase. Separase-deficient mouse embryonic fibroblasts exhibited severely restrained increases in cell number, polyploid chromosomes, and amplified centrosomes. Chromosome spreads demonstrated that multiple chromosomes connected to a centromeric region. Live observation demonstrated that the chromosomes of separase-deficient cells condensed, but failed to segregate, although subsequent cytokinesis and chromosome decondensation proceeded normally. These results establish that mammalian separase is essential for the separation of centromeres, but not of the arm regions of chromosomes. Other cell cycle events, such as mitotic exit, DNA replication, and centrosome duplication appear to occur normally. We also demonstrated that heterozygous separase-deficient cells exhibited severely restrained increases in cell number with apparently normal mitosis in the absence of securin, which is an inhibitory partner of separase.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Carrier Proteins (日) (読) [継承]
3. (英) Cell Cycle Proteins (日) (読) [継承]
4. (英) Cell Proliferation (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Centromere (日) (読) [継承]
7. (英) Centrosome (日) (読) [継承]
8. (英) Chromosome Segregation (日) (読) [継承]
9.細胞質分裂 (cytokinesis) [継承]
10. (英) Endopeptidases (日) (読) [継承]
11.女性 (female) [継承]
12. (英) Fibroblasts (日) (読) [継承]
13. (英) Interphase (日) (読) [継承]
14.男性 (male) [継承]
15. (英) Mice (日) (読) [継承]
16.ノックアウトマウス (knockout mice) [継承]
17. (英) Mitosis (日) (読) [継承]
18. (英) Polyploidy (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □The Journal of Cell Biology (Rockefeller Institute/American Society for Cell Biology)
(pISSN: 0021-9525, eISSN: 1540-8140)

○ISSN (任意): □0021-9525
ISSN: 0021-9525 (pISSN: 0021-9525, eISSN: 1540-8140)
Title: The Journal of cell biology
Title(ISO): J Cell Biol
Publisher: Rockefeller University Press
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □172 [継承]
○号 (必須): □6 [継承]
○頁 (必須): □835 846 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2006年 3月 初日 (平成 18年 3月 初日) [継承]
○URL (任意):
○DOI (任意): □10.1083/jcb.200511126    (→Scopusで検索) [継承]
○PMID (任意): □16533944    (→Scopusで検索) [継承]
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○WOS (任意):
○Scopus (任意): □2-s2.0-33644887985 [継承]
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○備考 (任意): 1.(英) Affiliation: Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 135-8550, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kazuki Kumada, Ryoji Yao, Tokuichi Kawaguchi, Mika Karasawa, Yutaka Hoshikawa, Koji Ichikawa, Yoshinobu Sugitani, Issei Imoto, Johji Inazawa, Minoru Sugawara, Mitsuhiro Yanagida and Tetsuo Noda : The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase., The Journal of Cell Biology, Vol.172, No.6, 835-846, 2006.
欧文冊子 ● Kazuki Kumada, Ryoji Yao, Tokuichi Kawaguchi, Mika Karasawa, Yutaka Hoshikawa, Koji Ichikawa, Yoshinobu Sugitani, Issei Imoto, Johji Inazawa, Minoru Sugawara, Mitsuhiro Yanagida and Tetsuo Noda : The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase., The Journal of Cell Biology, Vol.172, No.6, 835-846, 2006.

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