『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Yamamoto Sohei (日) (読)
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[継承]
2. (英) Tsuda Hitoshi (日) (読)
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[継承]
3. (英) Honda Kazufumi (日) (読)
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[継承]
4. (英) Onozato Kaoru (日) (読)
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[継承]
5. (英) Takano Masashi (日) (読)
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[継承]
6. (英) Tamai Seiichi (日) (読)
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[継承]
7.井本 逸勢
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8. (英) Inazawa Johji (日) (読)
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[継承]
9. (英) Yamada Tesshi (日) (読)
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[継承]
10. (英) Matsubara Osamu (日) (読)
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題名 (必須): (英) Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Actinin-4, an isoform of non-muscular alpha-actinin, enhances cell motility by bundling the actin cytoskeleton. We previously reported a prognostic implication of high immunohistochemical expression of actinin-4 protein in ovarian cancers. Chromosomal gain or amplification of the 19q12-q13 region has been reported in ovarian cancer. We hypothesized that the actinin-4 (ACTN4) gene might be a target of the 19q12-q13 amplicon and play an essential role of ovarian cancer progression. In total, 136 advanced-stage ovarian cancers were investigated for the copy number of the ACTN4 gene on chromosome 19q13, using fluorescence in situ hybridization, and the correlation of the ACTN4 copy number with actinin-4 protein immunoreactivity and major clinicopathological factors was investigated. A higher copy number (> or =4 copies) of the ACTN4 gene was detected in 29 (21%) cases and was highly associated with the intensity of actinin-4 immunoreactivity (P<0.0001), a high histological tumor grade (P=0.030), a clear-cell adenocarcinoma histology (P=0.012), resistance to first-line chemotherapies (P=0.028), and poor patient outcome (P=0.0011). Univariate analyses using the Cox regression model showed that a higher ACTN4 gene copy number was able to predict patient outcome more accurately than high actinin-4 immunoreactivity (relative risk: 2.48 vs 1.55). Multivariate analysis showed that a higher copy number of the ACTN4 gene and the degree of residual disease were independent prognostic factors for overall patient survival. The actinin-4 gene may be a target of the 19q amplicon, acting as a candidate oncogene, and serve as a predictor of poor outcome and tumor chemoresistance in patients with advanced-stage ovarian cancers.  (日)    [継承]
キーワード (推奨): 1. (英) Actinin (日) (読) [継承]
2. (英) Drug Resistance, Neoplasm (日) (読) [継承]
3.女性 (female) [継承]
4. (英) Gene Amplification (日) (読) [継承]
5. (英) Gene Dosage (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7.免疫組織化学 (immunohistochemistry) [継承]
8. (英) In Situ Hybridization, Fluorescence (日) (読) [継承]
9. (英) Kaplan-Meier Estimate (日) (読) [継承]
10. (英) Oncogenes (日) (読) [継承]
11. (英) Ovarian Neoplasms (日) (読) [継承]
12. (英) Prognosis (日) (読) [継承]
13. (英) Tissue Array Analysis (日) (読) [継承]
14. (英) Tumor Markers, Biological (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Modern Pathology (United States and Canadian Academy of Pathology)
(pISSN: 0893-3952, eISSN: 1530-0285)

ISSN (任意): 1530-0285
ISSN: 0893-3952 (pISSN: 0893-3952, eISSN: 1530-0285)
Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Title(ISO): Mod Pathol
Publisher: Springer Nature
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 22 [継承]
(必須): 4 [継承]
(必須): 499 507 [継承]
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年月日 (必須): 西暦 2009年 4月 22日 (平成 21年 4月 22日) [継承]
URL (任意):
DOI (任意): 10.1038/modpathol.2008.234    (→Scopusで検索) [継承]
PMID (任意): 19151661    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-63949087435 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Basic Pathology, National Defense Medical College, Tokorozawa, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov&apos;t  (日)    [継承]

標準的な表示

和文冊子 ● Sohei Yamamoto, Hitoshi Tsuda, Kazufumi Honda, Kaoru Onozato, Masashi Takano, Seiichi Tamai, Issei Imoto, Johji Inazawa, Tesshi Yamada and Osamu Matsubara : Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance., Modern Pathology, Vol.22, No.4, 499-507, 2009.
欧文冊子 ● Sohei Yamamoto, Hitoshi Tsuda, Kazufumi Honda, Kaoru Onozato, Masashi Takano, Seiichi Tamai, Issei Imoto, Johji Inazawa, Tesshi Yamada and Osamu Matsubara : Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance., Modern Pathology, Vol.22, No.4, 499-507, 2009.

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