『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Begum Asma (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.井本 逸勢
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Kozaki Ken-ichi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Tsuda Hitoshi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Suzuki Emina (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Amagasa Teruo (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Inazawa Johji (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Amplification of chromosomal DNA is thought to be one of the mechanisms activating cancer-related genes in tumors. To identify the most likely target for amplification in the region 19q13.12-q13.2, detected previously in SKN-3 cells by a genome-wide screening of DNA copy-number aberrations in a panel of oral squamous-cell carcinoma (OSCC) cell lines, we determined the extent of the amplicon, analyzed a panel of cell lines for the expression of candidate genes within the amplicon, and then evaluated growth-suppressive effects by knocking down genes of interest. Reported information about the function and/or expression of each gene, remarkable overexpression in SKN-3 cells and relatively frequent overexpression in additional OSCC lines compared with an immortalized normal oral epithelial cell line, and expression level-dependent proliferation-promoting activity led us to conclude that the p21-activated kinase 4 (PAK4) gene was the most likely target. An immunohistochemical analysis of primary tumors from 105 cases of head and neck SCC including 50 cases of OSCC demonstrated the overexpression of PAK4 to be significantly associated with a poorer prognosis. These findings reveal that the PAK4 overexpression through amplification or other mechanisms promotes the proliferation and/or survival of OSCC cells, and that PAK4 might be a good diagnostic and/or therapeutic target.  (日)    [継承]
キーワード (推奨): 1. (英) Blotting, Western (日) (読) [継承]
2. (英) Carcinoma, Squamous Cell (日) (読) [継承]
3. (英) Cell Line, Tumor (日) (読) [継承]
4. (英) Chromosomes, Human, Pair 19 (日) (読) [継承]
5. (英) DNA Mutational Analysis (日) (読) [継承]
6.女性 (female) [継承]
7. (英) Gene Amplification (日) (読) [継承]
8. (英) Gene Dosage (日) (読) [継承]
9. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11.免疫組織化学 (immunohistochemistry) [継承]
12. (英) In Situ Hybridization, Fluorescence (日) (読) [継承]
13.男性 (male) [継承]
14. (英) Middle Aged (日) (読) [継承]
15. (英) Mouth Neoplasms (日) (読) [継承]
16. (英) Neoplasm Staging (日) (読) [継承]
17. (英) Prognosis (日) (読) [継承]
18. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
19. (英) Tumor Markers, Biological (日) (読) [継承]
20. (英) p21-Activated Kinases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cancer Science ([日本癌学会])
(pISSN: 1347-9032, eISSN: 1349-7006)

ISSN (任意): 1349-7006
ISSN: 1347-9032 (pISSN: 1347-9032, eISSN: 1349-7006)
Title: Cancer science
Title(ISO): Cancer Sci
Publisher: Wiley-Blackwell
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 100 [継承]
(必須): 10 [継承]
(必須): 1908 1916 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 10月 初日 (平成 21年 10月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1349-7006.2009.01252.x    (→Scopusで検索) [継承]
PMID (任意): 19594544    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000269802000019 [継承]
Scopus (任意): 2-s2.0-70349591634 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Affiliation: Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Asma Begum, Issei Imoto, Ken-ichi Kozaki, Hitoshi Tsuda, Emina Suzuki, Teruo Amagasa and Johji Inazawa : Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma., Cancer Science, Vol.100, No.10, 1908-1916, 2009.
欧文冊子 ● Asma Begum, Issei Imoto, Ken-ichi Kozaki, Hitoshi Tsuda, Emina Suzuki, Teruo Amagasa and Johji Inazawa : Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma., Cancer Science, Vol.100, No.10, 1908-1916, 2009.

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