『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Haruki Shigeo (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2.井本 逸勢
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学籍番号 (推奨):
[継承]
3. (英) Kozaki Ken-ichi (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Matsui Takeshi (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Kawachi Hiroshi (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Komatsu Shuhei (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Muramatsu Tomoki (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Shimada Yutaka (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Kawano Tatsuyuki (日) (読)
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[継承]
10. (英) Inazawa Johji (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Protocadherins are a subfamily of the cadherin superfamily, but little is known about their functions. We identified a homozygous loss of protocadherin (PCDH) 17 in the course of a program to screen a panel of esophageal squamous cell carcinoma (ESCC) cell lines for genomic copy number aberrations. PCDH17 messenger RNA was expressed in normal esophageal tissue but not in the majority of ESCC cell lines without a homozygous deletion of this gene and restored in gene-silenced ESCC cells after treatment with 5-aza-2'-deoxycytidine. The DNA methylation status of the PCDH17 CpG island correlated inversely with the PCDH17 expression, and a putative methylation target region showed promoter activity. The methylation of the PCDH17 promoter was also associated with the silencing of gene expression in primary ESCC partly. Among primary ESCC cases, the silencing of PCDH17 protein expression was associated with a poorer differentiation status of ESCC cells and possibly with prognosis in a subset of this tumour. Restoration of PCDH17 expression in ESCC cells reduced cell proliferation and migration/invasion. These results suggest that silencing of PCDH17 expression through hypermethylation of the promoter or other mechanisms leads to loss of its tumour-suppressive activity, which may be a factor in the carcinogenesis of a subgroup of ESCCs.  (日)    [継承]
キーワード (推奨): 1. (英) Blotting, Western (日) (読) [継承]
2. (英) Cadherins (日) (読) [継承]
3. (英) Carcinoma, Squamous Cell (日) (読) [継承]
4. (英) Cell Line, Tumor (日) (読) [継承]
5. (英) Cell Movement (日) (読) [継承]
6. (英) Cell Proliferation (日) (読) [継承]
7. (英) CpG Islands (日) (読) [継承]
8. (英) DNA Methylation (日) (読) [継承]
9. (英) Esophageal Neoplasms (日) (読) [継承]
10. (英) Gene Silencing (日) (読) [継承]
11. (英) Genes, Tumor Suppressor (日) (読) [継承]
12. (英) Humans (日) (読) [継承]
13.免疫組織化学 (immunohistochemistry) [継承]
14. (英) Promoter Regions, Genetic (日) (読) [継承]
15. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Carcinogenesis ([Oxford University Press])
(pISSN: 0143-3334, eISSN: 1460-2180)

ISSN (任意): 1460-2180
ISSN: 0143-3334 (pISSN: 0143-3334, eISSN: 1460-2180)
Title: Carcinogenesis
Title(ISO): Carcinogenesis
Supplier: Oxford University Press
Publisher: Oxford University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 31 [継承]
(必須): 6 [継承]
(必須): 1027 1036 [継承]
都市 (任意):
年月日 (必須): 西暦 2010年 6月 初日 (平成 22年 6月 初日) [継承]
URL (任意):
DOI (任意): 10.1093/carcin/bgq053    (→Scopusで検索) [継承]
PMID (任意): 20200074    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-77953947951 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shigeo Haruki, Issei Imoto, Ken-ichi Kozaki, Takeshi Matsui, Hiroshi Kawachi, Shuhei Komatsu, Tomoki Muramatsu, Yutaka Shimada, Tatsuyuki Kawano and Johji Inazawa : Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma., Carcinogenesis, Vol.31, No.6, 1027-1036, 2010.
欧文冊子 ● Shigeo Haruki, Issei Imoto, Ken-ichi Kozaki, Takeshi Matsui, Hiroshi Kawachi, Shuhei Komatsu, Tomoki Muramatsu, Yutaka Shimada, Tatsuyuki Kawano and Johji Inazawa : Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma., Carcinogenesis, Vol.31, No.6, 1027-1036, 2010.

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