『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ooi Akishi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Zen Yoh (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Ninomiya Itasu (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Tajiri Ryousuke (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Suzuki Shioto (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Kobayashi Hideaki (日) (読)
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学籍番号 (推奨):
[継承]
7.井本 逸勢
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[継承]
8. (英) Dobashi Yoh (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Gene amplification of ERBB2 and EGFR in adenocarcinoma in situ and intramucosal adenocarcinoma of Barrett's esophagus.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We examined 11 cases of carcinoma arising from Barrett's esophagus consisting of two adenocarcinomas in situ (ACIS), two intramucosal adenocarcinomas, and seven overt invasive adenocarcinomas. Overexpression of p53 (implying a mutation of the p53 gene), ERBB2, and EGFR was measured by immunohistochemistry, and gene amplification of ERBB2 and EGFR was measured by fluorescence in situ hybridization (FISH). In all cases of ACIS and the intramucosal adenocarcinomas, almost all cancer cells overexpressed p53, however the populations overexpressing ERBB2 and EGFR varied in different cases: in one ACIS, ERBB2 was coexpressed in all the cancer cells, in the other ACIS and one intramucosal adenocarcinoma, ERBB2 was overexpressed in about 50% and only 10% of the p53-positive cells respectively. EGFR was co-expressed in 20% in the other intramucosal adenocarcinoma. Protein overexpression of ERBB2 or EGFR corresponded to the amplification of their respective genes on a cell by cell basis. These gene amplifications, however, were not found in the seven invasive adenocarcinomas. Thus we speculate that the gene amplification occurred late in the dysplasia-carcinoma sequence probably after the mutation of p53. Furthermore, new clonal expansion accompanied by tumor invasion might have extinguished the originally amplified genes in these tumors.  (日)    [継承]
キーワード (推奨): 1. (英) Adenocarcinoma (日) (読) [継承]
2. (英) Barrett Esophagus (日) (読) [継承]
3. (英) Carcinoma in Situ (日) (読) [継承]
4. (英) Esophagus (日) (読) [継承]
5. (英) Gene Amplification (日) (読) [継承]
6. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8.免疫組織化学 (immunohistochemistry) [継承]
9. (英) In Situ Hybridization, Fluorescence (日) (読) [継承]
10. (英) Mucous Membrane (日) (読) [継承]
11. (英) Neoplasm Invasiveness (日) (読) [継承]
12. (英) Receptor, Epidermal Growth Factor (日) (読) [継承]
13. (英) Receptor, erbB-2 (日) (読) [継承]
14. (英) Tumor Suppressor Protein p53 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Pathology International ([社団法人 日本病理学会])
(pISSN: 1320-5463, eISSN: 1440-1827)

ISSN (任意): 1440-1827
ISSN: 1320-5463 (pISSN: 1320-5463, eISSN: 1440-1827)
Title: Pathology international
Title(ISO): Pathol Int
Supplier: Japanese Society of Pathology
Publisher: Blackwell
 (NLM Catalog  (医中誌Web  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 60 [継承]
(必須): 6 [継承]
(必須): 466 471 [継承]
都市 (任意):
年月日 (必須): 西暦 2010年 6月 初日 (平成 22年 6月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1440-1827.2010.02545.x    (→Scopusで検索) [継承]
PMID (任意): 20518902    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-77952139352 [継承]
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被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Affiliation: Department of Molecular and Cellular Pathology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan. aooi@med.kanazawa-u.ac.jp  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Akishi Ooi, Yoh Zen, Itasu Ninomiya, Ryousuke Tajiri, Shioto Suzuki, Hideaki Kobayashi, Issei Imoto and Yoh Dobashi : Gene amplification of ERBB2 and EGFR in adenocarcinoma in situ and intramucosal adenocarcinoma of Barrett's esophagus., Pathology International, Vol.60, No.6, 466-471, 2010.
欧文冊子 ● Akishi Ooi, Yoh Zen, Itasu Ninomiya, Ryousuke Tajiri, Shioto Suzuki, Hideaki Kobayashi, Issei Imoto and Yoh Dobashi : Gene amplification of ERBB2 and EGFR in adenocarcinoma in situ and intramucosal adenocarcinoma of Barrett's esophagus., Pathology International, Vol.60, No.6, 466-471, 2010.

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