『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.伊藤 太二
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2. (英) Watanabe Hirotaka (日) (読)
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3. (英) Yamamichi Nobutake (日) (読)
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4. (英) Kondo Shunsuke (日) (読)
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5. (英) Tando Toshio (日) (読)
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6. (英) Haraguchi Takeshi (日) (読)
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7. (英) Mizutani Taketoshi (日) (読)
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8. (英) Sakurai Kouhei (日) (読)
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9. (英) Fujita Shuji (日) (読)
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10. (英) Izumi Tomonori (日) (読)
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11. (英) Isobe Toshiaki (日) (読)
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12. (英) Iba Hideo (日) (読)
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題名 (必須): (英) Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54(nrb).  (日)    [継承]
副題 (任意):
要約 (任意): (英) We report that a DBHS (Drosophila behaviour, human splicing) family protein, p54(nrb), binds both BRG1 (Brahma-related gene 1) and Brm (Brahma), catalytic subunits of the SWI/SNF (switch/sucrose non-fermentable) chromatin remodelling complex, and also another core subunit of this complex, BAF60a. The N-terminal region of p54(nrb) is sufficient to pull-down other core subunits of the SWI/SNF complex, suggesting that p54(nrb) binds SWI/SNF-like complexes. PSF (polypyrimidine tract-binding protein-associated splicing factor), another DBHS family protein known to directly bind p54(nrb), was also found to associate with the SWI/SNF-like complex. When sh (short hairpin) RNAs targeting Brm were retrovirally expressed in a BRG1-deficient human cell line (NCI-H1299), the resulting clones showed down-regulation of the TERT (telomerase reverse transcriptase) gene and an enhancement of ratios of exon-7-and-8-excluded TERT mRNA that encodes a beta-site-deleted inactive protein. All of these clones display growth arrest within 2 months of the Brm-knockdown. In NCI-H1299 cells, Brm, p54(nrb), PSF and RNA polymerase II phosphorylated on CTD (C-terminal domain) Ser(2) specifically co-localize at a region incorporating an alternative splicing acceptor site of TERT exon 7. These findings suggest that, at the TERT gene locus in human tumour cells containing a functional SWI/SNF complex, Brm, and possibly BRG1, in concert with p54(nrb), would initiate efficient transcription and could be involved in the subsequent splicing of TERT transcripts by accelerating exon-inclusion, which partly contributes to the maintenance of active telomerase.  (日)    [継承]
キーワード (推奨): 1. (英) Cell Line, Tumor (日) (読) [継承]
2. (英) Chromosomal Proteins, Non-Histone (日) (読) [継承]
3. (英) DNA Helicases (日) (読) [継承]
4. (英) Humans (日) (読) [継承]
5. (英) Nuclear Matrix-Associated Proteins (日) (読) [継承]
6. (英) Nuclear Proteins (日) (読) [継承]
7. (英) Octamer Transcription Factors (日) (読) [継承]
8. (英) RNA Splicing (日) (読) [継承]
9. (英) RNA, Messenger (日) (読) [継承]
10. (英) RNA-Binding Proteins (日) (読) [継承]
11. (英) Telomerase (日) (読) [継承]
12. (英) Transcription Factors (日) (読) [継承]
13. (英) Transcription, Genetic (日) (読) [継承]
14. (英) Transcriptional Activation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Biochemical Journal ([The Biochemical Society])
(pISSN: 0264-6021, eISSN: 1470-8728)

ISSN (任意): 1470-8728
ISSN: 0264-6021 (pISSN: 0264-6021, eISSN: 1470-8728)
Title: The Biochemical journal
Title(ISO): Biochem J
Publisher: Portland Press, Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2008年 4月 1日 (平成 20年 4月 1日) [継承]
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DOI (任意): 10.1042/BJ20071075    (→Scopusで検索) [継承]
PMID (任意): 18042045    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Host-Parasite Interaction, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Taiji Ito, Hirotaka Watanabe, Nobutake Yamamichi, Shunsuke Kondo, Toshio Tando, Takeshi Haraguchi, Taketoshi Mizutani, Kouhei Sakurai, Shuji Fujita, Tomonori Izumi, Toshiaki Isobe and Hideo Iba : Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54(nrb)., The Biochemical Journal, Vol.411, No.1, 201-209, 2008.
欧文冊子 ● Taiji Ito, Hirotaka Watanabe, Nobutake Yamamichi, Shunsuke Kondo, Toshio Tando, Takeshi Haraguchi, Taketoshi Mizutani, Kouhei Sakurai, Shuji Fujita, Tomonori Izumi, Toshiaki Isobe and Hideo Iba : Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54(nrb)., The Biochemical Journal, Vol.411, No.1, 201-209, 2008.

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