『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=223988)

EID=223988EID:223988, Map:0, LastModified:2015年3月3日(火) 09:46:41, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[松本 満], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[次世代酵素学研究領域]) [継承]
著者 (必須): 1. (英) Wada Naoko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Nishifuji Koji (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Yamada Taketo (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Kudoh Jun (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Shimizu Nobuyoshi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Peltonen Leena (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Nagafuchi Seiho (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Amagai Masayuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance  (日)    [継承]
副題 (任意):
要約 (任意): (英) In the mechanism of thymus-induced central tolerance, the transcription factor Aire has been demonstrated to promote the expression of a wide range of peripheral organ-specific antigens (Ags) in the medullary thymic epithelial cells (mTECs), which serve as self-Ags in negative selection. We examined the expression of desmoglein 3 (Dsg3), the autoantigen in pemphigus vulgaris (PV), in mouse thymus and the involvement of Aire in tolerance to Dsg3. Immunofluorescence and in situ hybridization revealed Dsg3 in single cells or in clusters in ∼3% of mTECs near the cortico-medullary junction of the thymus in C57BL/6 mice. Dsg3-expressing mTECs also expressed some Ags of skin-unrelated peripheral organs simultaneously. In contrast, Dsg3-positive mTECs were not detected in the Aire(-/-) thymus. Adoptive transfer of splenocytes from Aire(-/-) mice immunized with Dsg3 did not induce anti-Dsg3 IgG production or PV phenotype in Rag2(-/-) recipient mice. However, Aire(-/-) CD4(+) T cells, but not Aire(+/+) CD4(+) T cells, induced low levels of anti-Dsg3 IgG production when transferred with Dsg3(-/-) B cells. These findings indicate that Aire has an important role in Dsg3 expression as well as in selection of T cells that help B cells to produce anti-Dsg3 IgG in thymus.  (日)    [継承]
キーワード (推奨): 1. (英) Adaptive Immunity (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antibodies (日) (読) [継承]
4. (英) Autoantigens (日) (読) [継承]
5. (英) B-Lymphocytes (日) (読) [継承]
6. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
7. (英) DNA-Binding Proteins (日) (読) [継承]
8. (英) Desmoglein 3 (日) (読) [継承]
9. (英) Epithelial Cells (日) (読) [継承]
10. (英) Immune Tolerance (日) (読) [継承]
11. (英) Immunoglobulin G (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Inbred C57BL (日) (読) [継承]
14. (英) Mice, Knockout (日) (読) [継承]
15. (英) Models, Animal (日) (読) [継承]
16. (英) Pemphigus (日) (読) [継承]
17. (英) Thymus Gland (日) (読) [継承]
18. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Investigative Dermatology (The Society for Investigative Dermatology)
(pISSN: 0022-202X, eISSN: 1523-1747)

ISSN (任意): 1523-1747
ISSN: 0022-202X (pISSN: 0022-202X, eISSN: 1523-1747)
Title: The Journal of investigative dermatology
Title(ISO): J Invest Dermatol
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 131 [継承]
(必須): 2 [継承]
(必須): 410 417 [継承]
都市 (任意):
年月日 (必須): 西暦 2011年 2月 初日 (平成 23年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.1038/jid.2010.330    (→Scopusで検索) [継承]
PMID (任意): 21048786    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-78651386390 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Naoko Wada, Koji Nishifuji, Taketo Yamada, Jun Kudoh, Nobuyoshi Shimizu, Mitsuru Matsumoto, Leena Peltonen, Seiho Nagafuchi and Masayuki Amagai : Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance, The Journal of Investigative Dermatology, Vol.131, No.2, 410-417, 2011.
欧文冊子 ● Naoko Wada, Koji Nishifuji, Taketo Yamada, Jun Kudoh, Nobuyoshi Shimizu, Mitsuru Matsumoto, Leena Peltonen, Seiho Nagafuchi and Masayuki Amagai : Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance, The Journal of Investigative Dermatology, Vol.131, No.2, 410-417, 2011.

関連情報

Number of session users = 4, LA = 0.66, Max(EID) = 372573, Max(EOID) = 996602.