『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=22371EID:22371, Map:0, LastModified:2017年5月22日(月) 15:26:28, Operator:[三好 小文], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.京都大学 [継承]
著者 (必須): 1. (英) Masunaga Shin-ichiro (日) (読)
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[継承]
2. (英) Ono Koji (日) (読)
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[継承]
3. (英) Kirihata Mitsunori (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Takagaki Masao (日) (読)
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[継承]
5. (英) Sakurai Yoshinori (日) (読)
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[継承]
6. (英) Kinashi Yuko (日) (読)
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[継承]
7. (英) Kobayashi Tooru (日) (読)
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[継承]
8.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
役割 (任意): (英)   (日) TPZの合成を担当   [継承]
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学籍番号 (推奨):
[継承]
9.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
10.堀 均
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) EVALUATION OF THE POTENTIAL OF PARA-BORONOPHENYLALANINOL AS A BORON CARRIER IN BORON NEUTRON CAPTURE THERAPY, REFERRING TO THE EFFECT ON INTRATUMOR QUIESCENT CELLS  (日)    [継承]
副題 (任意):
要約 (任意): (英) C57BL mice bearing EL4 tumors and C3H / He mice bearing SCC VII tumors received 5-bromo-2'-deoxyuridine (BrdU) continuously for 5 days via implanted mini-osmotic pumps to label all proliferating (P) cells. Three hours after oral administration of l-p-boronophenylalanine-(10)B (BPA), or 30 min after intraperitoneal injection of sodium borocaptate-(10)B (BSH) or l-p-boronophenylalaninol (BPA-ol), a newly developed (10)B-containing alpha-amino alcohol, the tumors were irradiated with thermal neutron beams. For the combination with mild temperature hyperthermia (MTH) and / or tirapazamine (TPZ), the tumors were heated at 40 degrees C for 30 min immediately before neutron exposure, and TPZ was intraperitoneally injected 30 min before irradiation. The tumors were then excised, minced and trypsinized. The tumor cell suspensions thus obtained were incubated with cytochalasin-B (a cytokinesis blocker), and the micronucleus (MN) frequency in cells without BrdU labeling ( = quiescent (Q) cells) was determined using immunofluorescence staining for BrdU. Meanwhile, 6 h after irradiation, tumor cell suspensions obtained in the same manner were used for determining the apoptosis frequency in Q cells. The MN and apoptosis frequency in total (P + Q) tumor cells were determined from tumors that were not pretreated with BrdU. Without TPZ or MTH, BPA-ol increased both frequencies most markedly, especially for total cells. However, as with BPA, the sensitivity difference between total and Q cells was much larger than with BSH. On combined treatment with both MTH and TPZ, this sensitivity difference was markedly reduced, similarly to when BPA was used. MTH increased the (10)B uptake of all (10)B-compounds into both tumor cells. BPA-ol has good potential as a (10)B-carrier in neutron capture therapy, especially when combined with both MTH and TPZ.  (日) 本論文では,腫瘍移殖担癌マウスモデルにおいて,p-boronophenylalaninol(BPA-ol) の熱中性子照射における効果を明らかにした.BPA-olは腫瘍への取り込みが高い優れたボロンキャリアであり,マイルドハイパーサーミアまたはTPZとの併用でさらに増感されることを示した.   [継承]
キーワード (推奨): 1. (英) Administration, Oral (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antineoplastic Agents (日) (読) [継承]
4. (英) Apoptosis (日) (読) [継承]
5. (英) Boranes (日) (読) [継承]
6. (英) Boron Neutron Capture Therapy (日) (読) [継承]
7. (英) Bromodeoxyuridine (日) (読) [継承]
8. (英) Carcinoma, Squamous Cell (日) (読) [継承]
9. (英) Combined Modality Therapy (日) (読) [継承]
10. (英) Cytochalasin B (日) (読) [継承]
11. (英) Drug Screening Assays, Antitumor (日) (読) [継承]
12. (英) Fluorescent Antibody Technique, Indirect (日) (読) [継承]
13. (英) Hindlimb (日) (読) [継承]
14. (英) Hyperthermia, Induced (日) (読) [継承]
15. (英) Injections, Intraperitoneal (日) (読) [継承]
16. (英) Interphase (日) (読) [継承]
17. (英) Lymphoma (日) (読) [継承]
18. (英) Mice (日) (読) [継承]
19. (英) Mice, Inbred C3H (日) (読) [継承]
20. (英) Mice, Inbred C57BL (日) (読) [継承]
21. (英) Micronucleus Tests (日) (読) [継承]
22. (英) Molecular Structure (日) (読) [継承]
23. (英) Neutrons (日) (読) [継承]
24. (英) Phenylalanine (日) (読) [継承]
25. (英) Radiation-Sensitizing Agents (日) (読) [継承]
26. (英) Radiometry (日) (読) [継承]
27. (英) Triazines (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Japanese Journal of Cancer Research ([日本癌学会])
(pISSN: 0910-5050)

ISSN (任意): 0910-5050
ISSN: 0910-5050 (pISSN: 0910-5050, eISSN: 1876-4673)
Title: Japanese journal of cancer research : Gann
Title(ISO): Jpn. J. Cancer Res.
Supplier: 日本癌学会
Publisher: Oxford University Press
 (NLM Catalog  (医中誌Web  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 996 1007 [継承]
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年月日 (必須): 西暦 2001年 9月 1日 (平成 13年 9月 1日) [継承]
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PMID (任意): 11572769    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shin-ichiro Masunaga, Koji Ono, Mitsunori Kirihata, Masao Takagaki, Yoshinori Sakurai, Yuko Kinashi, Tooru Kobayashi, Hideko Nagasawa, Yoshihiro Uto and Hitoshi Hori : EVALUATION OF THE POTENTIAL OF PARA-BORONOPHENYLALANINOL AS A BORON CARRIER IN BORON NEUTRON CAPTURE THERAPY, REFERRING TO THE EFFECT ON INTRATUMOR QUIESCENT CELLS, Japanese Journal of Cancer Research, Vol.92, No.9, 996-1007, 2001.
欧文冊子 ● Shin-ichiro Masunaga, Koji Ono, Mitsunori Kirihata, Masao Takagaki, Yoshinori Sakurai, Yuko Kinashi, Tooru Kobayashi, Hideko Nagasawa, Yoshihiro Uto and Hitoshi Hori : EVALUATION OF THE POTENTIAL OF PARA-BORONOPHENYLALANINOL AS A BORON CARRIER IN BORON NEUTRON CAPTURE THERAPY, REFERRING TO THE EFFECT ON INTRATUMOR QUIESCENT CELLS, Japanese Journal of Cancer Research, Vol.92, No.9, 996-1007, 2001.

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