| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.ゲノム機能研究センター (〜2008年3月31日/->組織[徳島大学.疾患プロテオゲノム研究センター])
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| ○著者 (必須): | 1. | (英) Watanabe Masahiro (日) (読)
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| 2. | 山本 武範
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| 3. | (英) Kakuhata Rei (日) (読)
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| 4. | 岡田 直人
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| 5. | (英) Kajimoto Kazuaki (日) (読)
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| 6. | 山﨑 尚志 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学]/[徳島大学.薬学部.創製薬科学科.創薬学講座.衛生薬学]/[徳島大学.薬学研究科.創薬科学専攻])
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| 7. | 片岡 正俊
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| 8. | 馬場 嘉信
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| 9. | 玉置 俊晃
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| 10. | 篠原 康雄 ([徳島大学.先端酵素学研究所.基幹研究部門])
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| ○題名 (必須): | □ | (英) Synchronized changes in transcript levels of genes activating cold exposure-induced thermogenesis in brown adipose tissue of experimental animals. (日)
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| ○要約 (任意): | □ | (英) To identify genes whose expression in brown adipose tissue (BAT) is up- or down-regulated in cold-exposed rats, we performed microarray analysis of RNA samples prepared from the BAT of cold-exposed rats and of rats kept at room temperature. Previously reported elevations of transcript levels of uncoupling protein (UCP1), type II iodothyronine deiodinase (DIO2), and type III adenylate cyclase (AC3) in the BAT of cold-exposed rats over those in that of rats maintained at room temperature were confirmed. In addition to these changes, remarkable elevations of the transcript levels of several genes that seemed to be associated with the processes of cell-cycle regulation and DNA replication were detected in the BAT of cold-exposed rats, possibly reflecting the significant proliferation of brown adipocytes in response to cold exposure. Up-regulation of the gene encoding sarcomeric mitochondrial type creatine kinase in the BAT of cold-exposed rats was also detected by microarray analysis, but subsequent Northern analysis revealed that the expression of not only the sarcomeric mitochondrial type enzyme, but also that of 2 other subtypes, i.e., cytoplasmic brain type and cytoplasmic muscle type, was elevated in the BAT of cold-exposed rats. Microarray analysis also revealed a significant expression of myoglobin in BAT and its elevation in the BAT of cold-exposed rats, and this result was supported by calibrated Northern analysis. On the contrary, several genes such as regulator of G-protein signaling 2 and IMP dehydrogenase 1 were down-regulated in the BAT of cold-exposed rats. The physiological meaning of these changes accompanying cold exposure was discussed. (日)
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| ○キーワード (推奨): | 1. | (英) Adenylate Cyclase (日) (読)
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| 2. | (英) Adipose Tissue, Brown (日) (読)
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| 3. | (英) Amino Acid Sequence (日) (読)
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| 4. | (英) Animals (日) (読)
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| 5. | (英) Cold Temperature (日) (読)
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| 6. | (英) Creatine Kinase (日) (読)
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| 7. | (英) Gene Expression Regulation (日) (読)
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| 8. | (英) Iodide Peroxidase (日) (読)
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| 9. | (英) Ion Channels (日) (読)
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| 10. | (英) Male (日) (読)
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| 11. | (英) Mitochondrial Proteins (日) (読)
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| 12. | (英) Molecular Sequence Data (日) (読)
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| 13. | (英) Oligonucleotide Array Sequence Analysis (日) (読)
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| 14. | (英) RNA, Messenger (日) (読)
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| 15. | (英) Rats (日) (読)
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| 16. | (英) Rats, Wistar (日) (読)
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| 17. | (英) Thermogenesis (日) (読)
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| 18. | (英) Voltage-Dependent Anion Channel 1 (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biochimica et Biophysica Acta (BBA) - Bioenergetics ([Elsevier Science])
(pISSN: 0005-2728, eISSN: 1879-2650)
| ○ISSN (任意): | □ | 0005-2728
ISSN: 0005-2728
(pISSN: 0005-2728, eISSN: 1879-2650) Title: Biochimica et biophysica acta. BioenergeticsTitle(ISO): Biochim Biophys Acta BioenergPublisher: Elsevier B.V. (NLM Catalog)
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| ○巻 (必須): | □ | 1777
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 104 112
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 1月 初日 (平成 20年 1月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bbabio.2007.10.014 (→Scopusで検索)
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| ○PMID (任意): | □ | 18036333 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Institute for Genome Research, University of Tokushima, Kuramotocho-3, Tokushima 770-8503, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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