| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Nishimura Masuhiro (日) (読)
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| 2. | (英) Mikura Mayumi (日) (読)
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| 3. | 平坂 勝也
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| 4. | 奥村 裕司
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| 5. | 二川 健 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学])
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| 6. | (英) Kawano Yuichi (日) (読)
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| 7. | (英) Nakayama Mitsuo (日) (読)
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| 8. | (英) Ikeda Muneharu (日) (読)
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| ○題名 (必須): | □ | (英) Effects of dimethyl sulphoxide and dexamethasone on mRNA expression of myogenesis- and muscle proteolytic system-related genes in mouse myoblastic C2C12 cells (日)
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| ○要約 (任意): | □ | (英) We examined the time course of mRNA expression of myogenic cell differentiation- and muscle proteolytic system-related genes in cultures of C2C12 cells during differentiation from myoblasts to myotubes. Furthermore, we treated C2C12 myotubes with dimethyl sulphoxide (DMSO) and dexamethasone (Dex), and examined changes in these mRNA levels. Myogenin (Myog), Atrogin1, forkhead box O1 (Foxo1) and Capn1 mRNA levels increased in C2C12 cells differentiating from myoblasts to myotubes, whereas Myf5 mRNA levels decreased. Although genes such as MRF4, Foxo3a, UbB, Capn1 and MuRF1 mRNAs in the myotubes were affected by DMSO exposure, mRNA levels of other genes were not markedly affected by exposure to 0.02% or 0.5% DMSO. Myf5, MRF4, Atrogin1, Foxo3 and MuRF1 mRNA levels were elevated by Dex at all time points, Cbl and Capn1 mRNA levels were significantly elevated by Dex at 8 h, and Myog mRNA levels were significantly elevated by Dex at 24 h. However, CtsH mRNA levels decreased significantly with Dex at 24 h. This study provides a useful database of gene profiles that are differentially expressed throughout myogenic cell differentiation and the muscle proteolytic system. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | 細胞分化 (cell differentiation)
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| 3. | (英) Cell Line (日) (読)
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| 4. | (英) Dexamethasone (日) (読)
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| 5. | (英) Dimethyl Sulfoxide (日) (読)
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| 6. | 遺伝子発現 (gene expression)
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| 7. | (英) Mice (日) (読)
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| 8. | (英) Muscle Development (日) (読)
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| 9. | (英) Muscle Fibers, Skeletal (日) (読)
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| 10. | (英) RNA, Messenger (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Biochemistry ([日本生化学会])
(pISSN: 0021-924X, eISSN: 1756-2651)
| ○ISSN (任意): | □ | 0021-924X
ISSN: 0021-924X
(pISSN: 0021-924X, eISSN: 1756-2651) Title: Journal of biochemistryTitle(ISO): J BiochemSupplier: Oxford University PressPublisher: Oxford University Press (NLM Catalog)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 144
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 717 724
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 12月 初日 (平成 20年 12月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1093/jb/mvn126 (→Scopusで検索)
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| ○PMID (任意): | □ | 18835828 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000261681300004
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| ○Scopus (任意): | □ | 2-s2.0-57749195680
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Otsuka Pharmaceutical Factory, Inc., Naruto, Tokushima 772-8601, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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