『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.高田 健介
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Wang Xiaodan (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Hart Geoffrey T (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Odumade Oludare A (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Weinreich Michael A (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Hogquist Kristin A (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Jameson Stephen C (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The transcription factor Kruppel-like factor 2 (KLF2) was proposed to regulate genes involved in cell cycle entry and T cell trafficking; however, the physiological role of its expression in postactivated T cells is not well defined. Previous studies suggested that the cytokines IL-2 and IL-15 differentially regulate KLF2 re-expression in postactivation T cells and that these cytokines also influence effector versus memory T cell differentiation. Using conditional and inducible KLF2-knockout model systems, we tested the specific role of KLF2 expression in activated CD8(+) T cells cultured with these cytokines. KLF2 was required for effective transcription of sphingosine-1-phosphate receptor-1 (S1P(1)) and CD62L in postactivation T cells. However, although different cytokines dramatically altered the expression of cell-cycle-related genes, endogenous KLF2 had a minimal impact. Correspondingly, KLF2-deficient T cells showed dysregulated trafficking but not altered proliferative characteristics following in vivo responses to Ag. Thus, our data help to define KLF2-dependent and -independent aspects of activated CD8(+) T cell differentiation and argue against a physiological role in cell cycle regulation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens (日) (読) [継承]
3.アポトーシス (apoptosis) [継承]
4. (英) CD8-Positive T-Lymphocytes (日) (読) [継承]
5.細胞周期 (cell cycle) [継承]
6. (英) Cell Migration Inhibition (日) (読) [継承]
7. (英) Cell Movement (日) (読) [継承]
8. (英) Cells, Cultured (日) (読) [継承]
9. (英) G0 Phase (日) (読) [継承]
10. (英) Immunologic Memory (日) (読) [継承]
11. (英) Kruppel-Like Transcription Factors (日) (読) [継承]
12. (英) L-Selectin (日) (読) [継承]
13. (英) Lymphocyte Activation (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Inbred C57BL (日) (読) [継承]
16.ノックアウトマウス (knockout mice) [継承]
17. (英) Mice, Transgenic (日) (読) [継承]
18. (英) Nerve Tissue Proteins (日) (読) [継承]
19. (英) Ovalbumin (日) (読) [継承]
20. (英) Time Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 186 [継承]
(必須): 2 [継承]
(必須): 775 783 [継承]
都市 (任意):
年月日 (必須): 西暦 2010年 12月 15日 (平成 22年 12月 15日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.1000094    (→Scopusで検索) [継承]
PMID (任意): 21160050    (→Scopusで検索) [継承]
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WOS (任意):
Scopus (任意): 2-s2.0-79251566485 [継承]
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指導教員 (推奨):
備考 (任意): 1.(英) Affiliation: Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55414, USA. takada@genome.tokushima-u.ac.jp  (日)    [継承]
2.(英) PublicationType: Comparative Study  (日)    [継承]
3.(英) PublicationType: Journal Article  (日)    [継承]
4.(英) PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
5.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kensuke Takada, Xiaodan Wang, T Geoffrey Hart, A Oludare Odumade, A Michael Weinreich, A Kristin Hogquist and C Stephen Jameson : Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells., The Journal of Immunology, Vol.186, No.2, 775-783, 2010.
欧文冊子 ● Kensuke Takada, Xiaodan Wang, T Geoffrey Hart, A Oludare Odumade, A Michael Weinreich, A Kristin Hogquist and C Stephen Jameson : Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells., The Journal of Immunology, Vol.186, No.2, 775-783, 2010.

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