『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨): 博士課程学生による研究報告 [継承]
組織 (推奨):
著者 (必須): 1. (英) Tsukahara So (日) (読)
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2. (英) Ikeda Ryuji (日) (読)
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3. (英) Goto Shin (日) (読)
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4. (英) Yoshida Kenichi (日) (読)
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5. (英) Mitsumori Rie (日) (読)
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6. (英) Sakamoto Yoshiko (日) (読)
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7.田嶋 敦
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8. (英) Yokoyama Toru (日) (読)
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9. (英) Toh Satoshi (日) (読)
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10. (英) Furukawa Ken-ichi (日) (読)
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11. (英) Inoue Ituro (日) (読)
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題名 (必須): (英) Tumour necrosis factor alpha-stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by osteogenic differentiation medium and BMP-2.  (日)    [継承]
副題 (任意):
要約 (任意): (英) To better understand the molecular pathogenesis of OPLL (ossification of the posterior longitudinal ligament) of the spine, an ectopic bone formation disease, we performed cDNA microarray analysis on cultured ligament cells from OPLL patients. We found that TSG-6 (tumour necrosis factor alpha-stimulated gene-6) is down-regulated during osteoblastic differentiation. Adenovirus vector-mediated overexpression of TSG-6 inhibited osteoblastic differentiation of human mesenchymal stem cells induced by BMP (bone morphogenetic protein)-2 or OS (osteogenic differentiation medium). TSG-6 suppressed phosphorylation and nuclear accumulation of Smad 1/5 induced by BMP-2, probably by inhibiting binding of the ligand to the receptor, since interaction between TSG-6 and BMP-2 was observed in vitro. TSG-6 has two functional domains, a Link domain (a hyaluronan binding domain) and a CUB domain implicated in protein interaction. The inhibitory effect on osteoblastic differentiation was completely lost with exogenously added Link domain-truncated TSG-6, while partial inhibition was retained by the CUB domain-truncated protein. In addition, the inhibitory action of TSG-6 and the in vitro interaction of TSG-6 with BMP-2 were abolished by the addition of hyaluronan. Thus, TSG-6, identified as a down-regulated gene during osteoblastic differentiation, suppresses osteoblastic differentiation induced by both BMP-2 and OS and is a plausible target for therapeutic intervention in OPLL.  (日)    [継承]
キーワード (推奨): 1. (英) Alkaline Phosphatase (日) (読) [継承]
2. (英) Bone Morphogenetic Protein 2 (日) (読) [継承]
3. (英) Bone Morphogenetic Proteins (日) (読) [継承]
4. (英) Cell Adhesion Molecules (日) (読) [継承]
5.細胞分化 (cell differentiation) [継承]
6. (英) Culture Media (日) (読) [継承]
7. (英) Gene Expression Regulation (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Hyaluronic Acid (日) (読) [継承]
10. (英) Ligaments (日) (読) [継承]
11. (英) Mesenchymal Stem Cells (日) (読) [継承]
12. (英) Ossification, Heterotopic (日) (読) [継承]
13. (英) Osteoblasts (日) (読) [継承]
14.シグナル伝達 (signal transduction) [継承]
15. (英) Transforming Growth Factor beta (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Biochemical Journal ([The Biochemical Society])
(pISSN: 0264-6021, eISSN: 1470-8728)

ISSN (任意): 1470-8728
ISSN: 0264-6021 (pISSN: 0264-6021, eISSN: 1470-8728)
Title: The Biochemical journal
Title(ISO): Biochem J
Publisher: Portland Press, Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 398 [継承]
(必須): 3 [継承]
(必須): 595 603 [継承]
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年月日 (必須): 西暦 2006年 9月 15日 (平成 18年 9月 15日) [継承]
URL (任意):
DOI (任意): 10.1042/BJ20060027    (→Scopusで検索) [継承]
PMID (任意): 16771708    (→Scopusで検索) [継承]
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WOS (任意): 000240793800030 [継承]
Scopus (任意): 2-s2.0-33748757432 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Genetic Diagnosis, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC1559450  (日)    [継承]

標準的な表示

和文冊子 ● So Tsukahara, Ryuji Ikeda, Shin Goto, Kenichi Yoshida, Rie Mitsumori, Yoshiko Sakamoto, Atsushi Tajima, Toru Yokoyama, Satoshi Toh, Ken-ichi Furukawa and Ituro Inoue : Tumour necrosis factor alpha-stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by osteogenic differentiation medium and BMP-2., The Biochemical Journal, Vol.398, No.3, 595-603, 2006.
欧文冊子 ● So Tsukahara, Ryuji Ikeda, Shin Goto, Kenichi Yoshida, Rie Mitsumori, Yoshiko Sakamoto, Atsushi Tajima, Toru Yokoyama, Satoshi Toh, Ken-ichi Furukawa and Ituro Inoue : Tumour necrosis factor alpha-stimulated gene-6 inhibits osteoblastic differentiation of human mesenchymal stem cells induced by osteogenic differentiation medium and BMP-2., The Biochemical Journal, Vol.398, No.3, 595-603, 2006.

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