『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Nonaka Koichi (日) (読)
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[継承]
2. (英) Onizuka Shinya (日) (読)
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[継承]
3. (英) Ishibashi Hiromi (日) (読)
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[継承]
4.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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学籍番号 (推奨):
[継承]
5.堀 均
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学籍番号 (推奨):
[継承]
6. (英) Nakayama Toshiyuki (日) (読)
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[継承]
7. (英) Matsuura Nariaki (日) (読)
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[継承]
8. (英) Kanematsu Takashi (日) (読)
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[継承]
9. (英) Fujioka Hikaru (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Vitamin D Binding Protein-Macrophage Activating Factor Inhibits HCC in SCID Mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) A high incidence of recurrence after treatment is the most serious problem in hepatocellular carcinoma (HCC). Therefore, a new strategy for the treatment of the disease is needed. The aim of the present study was to investigate whether vitamin D binding protein-macrophage activating factor (DBP-maf) is able to inhibit the growth of HCC. The effects of DBP-maf on endothelial cells and macrophage were evaluated by WST-1 assay and phagocytosis assay, respectively. Human HCC cells (HepG2) were implanted into the dorsum of severe combined immunodeficiency (SCID) mice. These mice were divided into control and DBP-maf treatment groups (n = 10/group). The mice in the treatment group received 40 ng/kg/d of DBP-maf for 21 d. DBP-maf showed anti-proliferative activity against endothelial cells and also activated phagocytosis by macrophages. DBP-maf inhibited the growth of HCC cells (treatment group: 126 ± 18mm(3), untreated group: 1691.5 ± 546.9mm(3), P = 0.0077). Histologic examinations of the tumors revealed the microvessel density was reduced and more macrophage infiltration was demonstrated in the tumor of mice in the treatment group. DBP-maf has at least two novel functions, namely, an anti-angiogenic activity and tumor killing activity through the activation of macrophages. DBP-maf may therefore represent a new strategy for the treatment of HCC.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Carcinoma, Hepatocellular (日) (読) [継承]
3. (英) Cell Line, Tumor (日) (読) [継承]
4. (英) Cell Proliferation (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Disease Models, Animal (日) (読) [継承]
7. (英) Endothelium, Vascular (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Liver Neoplasms (日) (読) [継承]
10. (英) Macrophage-Activating Factors (日) (読) [継承]
11. (英) Macrophages (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Mice (日) (読) [継承]
14. (英) Mice, SCID (日) (読) [継承]
15. (英) Neovascularization, Pathologic (日) (読) [継承]
16. (英) Phagocytosis (日) (読) [継承]
17. (英) Rats (日) (読) [継承]
18. (英) Vitamin D-Binding Protein (日) (読) [継承]
19. (英) Xenograft Model Antitumor Assays (日) (読) [継承]
発行所 (推奨): Elsevier Science B.V. [継承]
誌名 (必須): The Journal of Surgical Research (Association for Academic Surgery (U.S.)/Association of Veterans Administration Surgeons (U.S.))
(pISSN: 0022-4804, eISSN: 1095-8673)

ISSN (任意): 1095-8673
ISSN: 0022-4804 (pISSN: 0022-4804, eISSN: 1095-8673)
Title: The Journal of surgical research
Title(ISO): J. Surg. Res.
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 172 [継承]
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年月日 (必須): 西暦 2012年 1月 初日 (平成 24年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/j.jss.2010.07.057    (→Scopusで検索) [継承]
PMID (任意): 20855083    (→Scopusで検索) [継承]
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WOS (任意): 000298217000018 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.jss.2010.07.057  (日)    [継承]
2.(英) Article.Affiliation: Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Japan. kknonaka@mbn.nifty.com  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Koichi Nonaka, Shinya Onizuka, Hiromi Ishibashi, Yoshihiro Uto, Hitoshi Hori, Toshiyuki Nakayama, Nariaki Matsuura, Takashi Kanematsu and Hikaru Fujioka : Vitamin D Binding Protein-Macrophage Activating Factor Inhibits HCC in SCID Mice, The Journal of Surgical Research, Vol.172, No.1, 116-122, 2012.
欧文冊子 ● Koichi Nonaka, Shinya Onizuka, Hiromi Ishibashi, Yoshihiro Uto, Hitoshi Hori, Toshiyuki Nakayama, Nariaki Matsuura, Takashi Kanematsu and Hikaru Fujioka : Vitamin D Binding Protein-Macrophage Activating Factor Inhibits HCC in SCID Mice, The Journal of Surgical Research, Vol.172, No.1, 116-122, 2012.

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