『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=222898EID:222898, Map:0, LastModified:2013年9月10日(火) 19:00:01, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 英語 [継承]
招待 (推奨): 依頼 [継承]
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨): 1.大学院ソシオテクノサイエンス研究部.ライフシステム部門 (2006年4月1日〜) [継承]
著者 (必須): 1.堀 均
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2.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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[継承]
3.中田 栄司
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[継承]
題名 (必須): (英) Medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and invention of boron tracedrugs as innovative future-architectural drugs  (日)    [継承]
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要約 (任意): (英) We describe herein for the first time our medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and boron tracedrugs as newly emerging drug classes. A new area of antineoplastic drugs and treatments has recently focused on neoplastic cells of the tumor environment/microenvironment involving accessory cells. This tumor hypoxic environment is now considered as a major factor that influences not only the response to antineoplastic therapies but also the potential for malignant progression and metastasis. We review our medicinal electronomics bricolage design of hypoxia-targeting drugs, antiangiogenic hypoxic cell radiosensitizers, sugar-hybrid hypoxic cell radiosensitizers, and hypoxia-targeting 10B delivery agents, in which we design drug candidates based on their electronic structures obtained by molecular orbital calculations, not based solely on pharmacophore development. These drugs include an antiangiogenic hypoxic cell radiosensitizer TX-2036, a sugar-hybrid hypoxic cell radiosensitizer TX-2244, new hypoxia-targeting indoleamine 2,3-dioxygenase (IDO) inhibitors, and a hypoxia-targeting BNCT agent, BSH (sodium borocaptate-10B)-hypoxic cytotoxin tirapazamine (TPZ) hybrid drug TX-2100. We then discuss the concept of boron tracedrugs as a new drug class having broad potential in many areas.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antineoplastic Agents (日) (読) [継承]
3. (英) Boron Compounds (日) (読) [継承]
4. (英) Cell Hypoxia (日) (読) [継承]
5. (英) Drug Design (日) (読) [継承]
6. (英) Electrons (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Neoplasms (日) (読) [継承]
9. (英) Radiation-Sensitizing Agents (日) (読) [継承]
発行所 (推奨): (英) The International Institute of Anticancer Research (日) (読) [継承]
誌名 (必須): Anticancer Research (International Institute of Anticancer Research(IIAR))
(pISSN: 0250-7005, eISSN: 1791-7530)

ISSN (任意): 1791-7530
ISSN: 0250-7005 (pISSN: 0250-7005, eISSN: 1791-7530)
Title: Anticancer research
Title(ISO): Anticancer Res.
Publisher: International Institute of Anticancer Research
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 30 [継承]
(必須): 9 [継承]
(必須): 3233 3242 [継承]
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年月日 (必須): 西暦 2010年 9月 末日 (平成 22年 9月 末日) [継承]
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PMID (任意): 20944092    (→Scopusで検索) [継承]
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WOS (任意): 000283009400002 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Life System, Institute of Technology and Science, Graduate School, the University of Tokushima, Minamijosanjimacho-2, Tokushima 770-8506, Japan. hori@bio.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]

標準的な表示

和文冊子 ● Hitoshi Hori, Yoshihiro Uto and Eiji Nakata : Medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and invention of boron tracedrugs as innovative future-architectural drugs, Anticancer Research, Vol.30, No.9, 3233-3242, Sep. 2010.
欧文冊子 ● Hitoshi Hori, Yoshihiro Uto and Eiji Nakata : Medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and invention of boron tracedrugs as innovative future-architectural drugs, Anticancer Research, Vol.30, No.9, 3233-3242, Sep. 2010.

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Number of session users = 3, LA = 0.43, Max(EID) = 361877, Max(EOID) = 968232.