『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=222687)

EID=222687EID:222687, Map:0, LastModified:2012年9月21日(金) 15:42:57, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[佐々木 卓也], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Tabata Keisuke (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Matsunaga Kohichi (日) (読)
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3.坂根 亜由子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.生化学])
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学籍番号 (推奨):
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4.佐々木 卓也 ([徳島大学])
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5. (英) Noda Takeshi (日) (読)
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6. (英) Yoshimori Tamotsu (日) (読)
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学籍番号 (推奨):
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題名 (必須): (英) Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The endocytic and autophagic pathways are involved in the membrane trafficking of exogenous and endogenous materials to lysosomes. However, the mechanisms that regulate these pathways are largely unknown. We previously reported that Rubicon, a Beclin 1-binding protein, negatively regulates both the autophagic and endocytic pathways by unidentified mechanisms. In this study, we performed database searches to identify potential Rubicon homologues that share the common C-terminal domain, termed the RH domain. One of them, PLEKHM1, the causative gene of osteopetrosis, also suppresses endocytic transport but not autophagosome maturation. Rubicon and PLEKHM1 specifically and directly interact with Rab7 via their RH domain, and this interaction is critical for their function. Furthermore, we show that Rubicon but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 and PI3-kinase.  (日)    [継承]
キーワード (推奨): 1. (英) Adaptor Proteins, Signal Transducing (日) (読) [継承]
2. (英) Apoptosis Regulatory Proteins (日) (読) [継承]
3. (英) Autophagy (日) (読) [継承]
4. (英) Endocytosis (日) (読) [継承]
5. (英) HeLa Cells (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Immunoblotting (日) (読) [継承]
8. (英) Intracellular Signaling Peptides and Proteins (日) (読) [継承]
9. (英) Lysosomes (日) (読) [継承]
10. (英) Membrane Glycoproteins (日) (読) [継承]
11. (英) Membrane Proteins (日) (読) [継承]
12. (英) Membrane Transport Modulators (日) (読) [継承]
13. (英) Microscopy, Fluorescence (日) (読) [継承]
14. (英) Phosphatidylinositol 3-Kinases (日) (読) [継承]
15. (英) Protein Interaction Domains and Motifs (日) (読) [継承]
16. (英) Protein Transport (日) (読) [継承]
17. (英) rab GTP-Binding Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Molecular Biology of the Cell (The American Society for Cell Biology)
(pISSN: 1059-1524, eISSN: 1939-4586)

ISSN (任意): 1939-4586
ISSN: 1059-1524 (pISSN: 1059-1524, eISSN: 1939-4586)
Title: Molecular biology of the cell
Title(ISO): Mol Biol Cell
Publisher: American Society for Cell Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 21 [継承]
(必須): 23 [継承]
(必須): 4162 4173 [継承]
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年月日 (必須): 西暦 2010年 12月 21日 (平成 22年 12月 21日) [継承]
URL (任意):
DOI (任意): 10.1091/mbc.E10-06-0495    (→Scopusで検索) [継承]
PMID (任意): 20943950    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Genetics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC2993745  (日)    [継承]

標準的な表示

和文冊子 ● Keisuke Tabata, Kohichi Matsunaga, Ayuko Sakane, Takuya Sasaki, Takeshi Noda and Tamotsu Yoshimori : Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain., Molecular Biology of the Cell, Vol.21, No.23, 4162-4173, 2010.
欧文冊子 ● Keisuke Tabata, Kohichi Matsunaga, Ayuko Sakane, Takuya Sasaki, Takeshi Noda and Tamotsu Yoshimori : Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain., Molecular Biology of the Cell, Vol.21, No.23, 4162-4173, 2010.

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