『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Min Li-Juan (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Cui Tai-Xing (日) (読)
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[継承]
3. (英) Yahata Yoko (日) (読)
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[継承]
4. (英) Yamasaki Kenshi (日) (読)
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[継承]
5. (英) Liu Hong-Wei (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Chen Rui (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Li Jian-Mei (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Okumura Midori (日) (読)
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[継承]
9. (英) Jinno Toyohisa (日) (読)
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[継承]
10. (英) Wu Lan (日) (読)
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学籍番号 (推奨):
[継承]
11. (英) Iwai Masaru (日) (読)
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学籍番号 (推奨):
[継承]
12. (英) Nahmias Clara (日) (読)
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学籍番号 (推奨):
[継承]
13. (英) Hashimoto Koji (日) (読)
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学籍番号 (推奨):
[継承]
14. (英) Horiuchi Masatsugu (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Regulation of collagen synthesis in mouse skin fibroblasts by distinct angiotensin II receptor subtypes.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We examined the possibility of whether angiotensin (Ang) II type 1 (AT1) and type 2 (AT2) receptor stimulation differentially regulates collagen production in mouse skin fibroblasts. Both AT1 and AT2 receptors were expressed in neonatal skin fibroblasts prepared from wild-type mice to a similar degree, and the AT1a receptor was exclusively expressed as opposed to the AT1b receptor. In wild-type fibroblasts, Ang II increased collagen synthesis accompanied by an increase in expression of tissue inhibitor of metalloproteinase (TIMP)-1, and these increases were inhibited by valsartan, an AT1 receptor blocker, but augmented by PD123319, an AT2 receptor antagonist. Ang II decreased basal and IGF-I-induced collagen production and inhibited TIMP-1 expression in neonatal skin fibroblasts prepared from AT1a knockout (KO) mice. These Ang II-mediated inhibitory effects on collagen production and TIMP-1 expression observed in AT1a KO fibroblasts were attenuated by the addition of PD123319 or a tyrosine phosphatase inhibitor, sodium orthovanadate, but not affected by a serine/threonine phosphatase inhibitor, okadaic acid. Moreover, we demonstrated that transfection of a catalytically inactive, dominant negative SHP-1 (Src homology 2-containing protein-tyrosine phosphatase-1) mutant inhibited the Ang II-mediated inhibitory effect on both collagen synthesis and TIMP-1 expression in AT1a KO fibroblasts. These results suggest that AT1a receptor stimulation increases collagen production in skin fibroblasts at least in part due to the inhibition of collagen degradation via the increase in TIMP-1 expression, whereas AT2 receptor stimulation exerts inhibitory effects on TIMP-1 expression, which is mediated at least partially by the activation of SHP-1, thereby possibly inhibiting collagen production.  (日)    [継承]
キーワード (推奨): 1. (英) Animals, Newborn (日) (読) [継承]
2. (英) Cells, Cultured (日) (読) [継承]
3. (英) Collagen (日) (読) [継承]
4. (英) Enzyme Inhibitors (日) (読) [継承]
5. (英) Fibroblasts (日) (読) [継承]
6. (英) Gene Expression (日) (読) [継承]
7. (英) Intracellular Signaling Peptides and Proteins (日) (読) [継承]
8. (英) Male (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Knockout (日) (読) [継承]
11. (英) Okadaic Acid (日) (読) [継承]
12. (英) Protein Phosphatase 1 (日) (読) [継承]
13. (英) Protein Tyrosine Phosphatase, Non-Receptor Type 1 (日) (読) [継承]
14. (英) Protein Tyrosine Phosphatase, Non-Receptor Type 6 (日) (読) [継承]
15. (英) Protein Tyrosine Phosphatases (日) (読) [継承]
16. (英) Receptor, Angiotensin, Type 1 (日) (読) [継承]
17. (英) Receptor, Angiotensin, Type 2 (日) (読) [継承]
18. (英) Skin (日) (読) [継承]
19. (英) Tissue Inhibitor of Metalloproteinase-1 (日) (読) [継承]
20. (英) Vanadates (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 145 [継承]
(必須): 1 [継承]
(必須): 253 260 [継承]
都市 (任意):
年月日 (必須): 西暦 2003年 10月 9日 (平成 15年 10月 9日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2003-0673    (→Scopusで検索) [継承]
PMID (任意): 14551224    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Medical Biochemistry, Ehime University Medical School, Onsen-gun, Ehime 791-0295, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Li-Juan Min, Tai-Xing Cui, Yoko Yahata, Kenshi Yamasaki, Hong-Wei Liu, Rui Chen, Jian-Mei Li, Midori Okumura, Toyohisa Jinno, Lan Wu, Masaru Iwai, Clara Nahmias, Koji Hashimoto and Masatsugu Horiuchi : Regulation of collagen synthesis in mouse skin fibroblasts by distinct angiotensin II receptor subtypes., Endocrinology, Vol.145, No.1, 253-260, 2003.
欧文冊子 ● Li-Juan Min, Tai-Xing Cui, Yoko Yahata, Kenshi Yamasaki, Hong-Wei Liu, Rui Chen, Jian-Mei Li, Midori Okumura, Toyohisa Jinno, Lan Wu, Masaru Iwai, Clara Nahmias, Koji Hashimoto and Masatsugu Horiuchi : Regulation of collagen synthesis in mouse skin fibroblasts by distinct angiotensin II receptor subtypes., Endocrinology, Vol.145, No.1, 253-260, 2003.

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