『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=221429EID:221429, Map:0, LastModified:2012年8月29日(水) 12:47:42, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[志内 哲也], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Miura Shinji (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kawanaka Kentaro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Kai Yuko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Tamura Mayumi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Goto Masahide (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.志内 哲也 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Minokoshi Yasuhiko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Ezaki Osamu (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation.  (日)    [継承]
副題 (任意):
要約 (任意): (英) A single bout of exercise increases expression of peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha mRNA, which may promote mitochondrial biogenesis in skeletal muscle. In brown adipose tissue, cold exposure up-regulates PGC-1alpha expression via adrenergic receptor (AR) activation. Because exercise also activates the sympathetic nervous system, we examined whether exercise-induced increase in PGC-1alpha mRNA expression in skeletal muscle was mediated via AR activation. In C57BL/6J mice, injection of the beta2-AR agonist clenbuterol, but not alpha-, beta1-, or beta3-AR agonists, increased PGC-1alpha mRNA expression more than 30-fold in skeletal muscle. The clenbuterol-induced increase in PGC-1alpha mRNA expression in mice was inhibited by pretreatment with the beta-AR antagonist propranolol. In ex vivo experiments, direct exposure of rat epitrochlearis to beta2-AR agonist, but not alpha-, beta1-, and beta3-AR agonist, led to an increase in levels of PGC-1alpha mRNA. Injection of beta2-AR agonist did not increase PGC-1alpha mRNA expression in beta1-, beta2-, and beta3-AR knockout mice (beta-less mice). PGC-1alpha mRNA in gastrocnemius was increased 3.5-fold in response to running on a treadmill for 45 min. The exercise-induced increase in PGC-1alpha mRNA was inhibited by approximately 70% by propranolol or the beta2-AR-specific inhibitor ICI 118,551. The exercise-induced increase in PGC-1alpha mRNA in beta-less mice was also 36% lower than that in wild-type mice. These data indicate that up-regulation of PGC-1alpha expression in skeletal muscle by exercise is mediated, at least in part, by beta-ARs activation. Among ARs, beta2-AR may mediate an increase in PGC-1alpha by exercise.  (日)    [継承]
キーワード (推奨): 1. (英) Adrenergic beta-1 Receptor Agonists (日) (読) [継承]
2. (英) Adrenergic beta-2 Receptor Agonists (日) (読) [継承]
3. (英) Adrenergic beta-3 Receptor Agonists (日) (読) [継承]
4. (英) Adrenergic beta-Agonists (日) (読) [継承]
5. (英) Animals (日) (読) [継承]
6. (英) Blotting, Northern (日) (読) [継承]
7. (英) Clenbuterol (日) (読) [継承]
8. (英) Dioxoles (日) (読) [継承]
9. (英) Dobutamine (日) (読) [継承]
10. (英) Gene Expression Regulation (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Mice, Inbred C57BL (日) (読) [継承]
13. (英) Mice, Knockout (日) (読) [継承]
14. (英) Muscle, Skeletal (日) (読) [継承]
15. (英) Phenylephrine (日) (読) [継承]
16. (英) Physical Conditioning, Animal (日) (読) [継承]
17. (英) Propranolol (日) (読) [継承]
18. (英) RNA, Messenger (日) (読) [継承]
19. (英) Receptors, Adrenergic, alpha (日) (読) [継承]
20. (英) Receptors, Adrenergic, beta (日) (読) [継承]
21. (英) Receptors, Adrenergic, beta-1 (日) (読) [継承]
22. (英) Receptors, Adrenergic, beta-2 (日) (読) [継承]
23. (英) Receptors, Adrenergic, beta-3 (日) (読) [継承]
24. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
25. (英) Trans-Activators (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Oxford University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 148 [継承]
(必須): 7 [継承]
(必須): 3441 3448 [継承]
都市 (任意):
年月日 (必須): 西暦 2007年 4月 19日 (平成 19年 4月 19日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2006-1646    (→Scopusで検索) [継承]
PMID (任意): 17446185    (→Scopusで検索) [継承]
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Scopus (任意):
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指導教員 (推奨):
備考 (任意): 1.(英) Affiliation: Nutritional Science Program, National Institute of Health and Nutrition, 1-23-1, Toyama, Shinjuku-ku, Tokyo 162-8636, Japan. shinjim@nih.go.jp  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shinji Miura, Kentaro Kawanaka, Yuko Kai, Mayumi Tamura, Masahide Goto, Tetsuya Shiuchi, Yasuhiko Minokoshi and Osamu Ezaki : An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation., Endocrinology, Vol.148, No.7, 3441-3448, 2007.
欧文冊子 ● Shinji Miura, Kentaro Kawanaka, Yuko Kai, Mayumi Tamura, Masahide Goto, Tetsuya Shiuchi, Yasuhiko Minokoshi and Osamu Ezaki : An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation., Endocrinology, Vol.148, No.7, 3441-3448, 2007.

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