『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=221420)

EID=221420EID:221420, Map:0, LastModified:2012年8月29日(水) 12:46:28, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[志内 哲也], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Sasaki Tsutomu (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kim Hye-Jin (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Kobayashi Masaki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Kitamura Yukari-Ido (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Yokota-Hashimoto Hiromi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.志内 哲也 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Minokoshi Yasuhiko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Kitamura Tadahiro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Silent information regulator (SIR)2 is an nicotinamide adenine dinucleotide dependent deacetylase implicated in the regulation of life span in species as diverse as yeast, worms, and flies. Mammalian Sirt1 is the most closely related homolog of the SIR2 gene. Pharmacological activators of Sirt1 have been reported to increase the life span and improve the health of mice fed a high-fat diet and to reverse diabetes in rodents. Sirt1 links the energy availability status with cellular metabolism in peripheral organs including liver, pancreas, muscle, and white adipose tissue. Insulin and leptin signaling regulate food intake by controlling the expression of orexigenic and anorexigenic neuropeptides in the arcuate nucleus of the hypothalamus via Forkhead box O (Foxo)-1 and signal transducer and activator of transcription-3. Sirt1 has been reported to improve insulin sensitivity in vitro, but the role of hypothalamic Sirt1 in regulating feeding has not been addressed. We found that hypothalamic Sirt1 protein levels increase on feeding, and this induction is abrogated in diet-induced obese mice and db/db mice. We also demonstrate for the first time that Sirt1 protein turnover is regulated by the proteasome and ubiquitination in a hypothalamic cell line and in vivo by feeding, and this regulation is not seen in a pituitary cell line AtT20. Forced expression of wild-type Sirt1 in the mediobasal hypothalamus by adenovirus microinjection suppressed Foxo1-induced hyperphagia, a model for central insulin resistance. Moreover, Sirt1 suppressed Foxo1-dependent expression of the orexigenic neuropeptide Agouti-related peptide in vitro. We propose that on feeding, Sirt1 protein is stabilized in the hypothalamus, leading to decreased Foxo1-dependent expression of orexigenic neuropeptide Agouti-related peptide and cessation of feeding.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Blotting, Western (日) (読) [継承]
3. (英) Cell Line (日) (読) [継承]
4. (英) Feeding Behavior (日) (読) [継承]
5. (英) Forkhead Transcription Factors (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Hyperphagia (日) (読) [継承]
8. (英) Hypothalamus (日) (読) [継承]
9. (英) Immunohistochemistry (日) (読) [継承]
10. (英) Immunoprecipitation (日) (読) [継承]
11. (英) Male (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Inbred C57BL (日) (読) [継承]
14. (英) Proteasome Endopeptidase Complex (日) (読) [継承]
15. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
16. (英) Sirtuin 1 (日) (読) [継承]
17. (英) Weight Gain (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 1945-7170
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 151 [継承]
(必須): 6 [継承]
(必須): 2556 2566 [継承]
都市 (任意):
年月日 (必須): 西暦 2010年 4月 7日 (平成 22年 4月 7日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2009-1319    (→Scopusで検索) [継承]
PMID (任意): 20375183    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Affiliation: Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi-shi, Gunma 371-8512, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tsutomu Sasaki, Hye-Jin Kim, Masaki Kobayashi, Yukari-Ido Kitamura, Hiromi Yokota-Hashimoto, Tetsuya Shiuchi, Yasuhiko Minokoshi and Tadahiro Kitamura : Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide., Endocrinology, Vol.151, No.6, 2556-2566, 2010.
欧文冊子 ● Tsutomu Sasaki, Hye-Jin Kim, Masaki Kobayashi, Yukari-Ido Kitamura, Hiromi Yokota-Hashimoto, Tetsuya Shiuchi, Yasuhiko Minokoshi and Tadahiro Kitamura : Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide., Endocrinology, Vol.151, No.6, 2556-2566, 2010.

関連情報

Number of session users = 0, LA = 1.18, Max(EID) = 383294, Max(EOID) = 1024468.