『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=219833EID:219833, Map:0, LastModified:2012年9月20日(木) 16:04:57, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[細井 和雄], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座.口腔分子生理学 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1. (英) Azlina, Ahmad (日) Azlina, Ahmad (読)
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2. (英) Javkhlan, Purevjav (日) Javkhlan, Purevjav (読)
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3.廣島 佑香 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔微生物学])
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4.長谷川 敬展 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
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5.姚 陳娟 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
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6.赤松 徹也 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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7.細井 和雄
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題名 (必須): (英) Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation  (日)    [継承]
副題 (任意):
要約 (任意): (英) Chorda tympani denervation (CTD) of rats was earlier shown to result in loss of submandibular gland (SMG) weight (at only 1 wk) and in continued reduction in aquaporin 5 (AQP5) protein expression (until 4 wk), without affecting its mRNA synthesis (Li X, Azlina A, Karabasil MR, Purwanti N, Hasegawa T, Yao C, Akamatsu T, Hosoi K. Am J Physiol Gastrointest Liver Physiol 295: G112-G123, 2008). The present study indicated that despite elevation of bax, a proapoptosis protein, by CTD, the operation also increased the level of bcl-2, an antiapoptosis protein, in the SMG. Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL assay) showed no increase in the number of apoptotic cells in the SMG. CTD, however, induced strongly and transiently (at 1-3 days) the protein expression of LC3B-II, a marker protein of autophagosomes, suggesting that the reduction in the gland weight was due to onset of autophagy by CTD. Upon CTD, Lamp2, a lysosomal marker, gradually increased in amount, reaching a peak at the 14th day. Immunohistochemical analysis revealed an increase in the number of lysosome-like structures positive for both AQP5 and Lamp2 in the acinar cells of the SMG after CTD; similar changes were observed also for AQP5 and LC3Bs. These data suggest that AQP5 in the SMG entered autophagosomes and/or lysosomes for degradation upon CTD. In vitro AQP5-degrading activity was found in the SMG extracts, and such activity was shown to be increased by CTD. Inhibitor experiments implied cathepsins B and L to be candidate enzymes for this degradation under normal and CTD conditions, respectively.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Apoptosis (日) (読) [継承]
3. (英) Aquaporin 5 (日) (読) [継承]
4. (英) Blotting, Western (日) (読) [継承]
5. (英) Chorda Tympani Nerve (日) (読) [継承]
6. (英) Immunohistochemistry (日) (読) [継承]
7. (英) In Situ Nick-End Labeling (日) (読) [継承]
8. (英) Lysosomal-Associated Membrane Protein 2 (日) (読) [継承]
9. (英) Lysosomes (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Parasympathectomy (日) (読) [継承]
12. (英) Proto-Oncogene Proteins c-bcl-2 (日) (読) [継承]
13. (英) Rats (日) (読) [継承]
14. (英) Rats, Sprague-Dawley (日) (読) [継承]
15. (英) Submandibular Gland (日) (読) [継承]
発行所 (推奨): (英) The American Physioogical Society (日) (読) [継承]
誌名 (必須): American Journal of Physiology, Gastrointestinal and Liver Physiology ([アメリカ生理学会])
(pISSN: 0193-1857, eISSN: 1522-1547)

ISSN (任意): 1522-1547
ISSN: 0193-1857 (pISSN: 0193-1857, eISSN: 1522-1547)
Title: American journal of physiology. Gastrointestinal and liver physiology
Title(ISO): Am J Physiol Gastrointest Liver Physiol
Publisher: American Physiological Society
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(必須): 299 [継承]
(必須): 5 [継承]
(必須): G1106 G1117 [継承]
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年月日 (必須): 西暦 2010年 11月 初日 (平成 22年 11月 初日) [継承]
URL (任意):
DOI (任意): 10.1152/ajpgi.00194.2010    (→Scopusで検索) [継承]
PMID (任意): 20689061    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Ahmad Azlina, Purevjav Javkhlan, Yuka Hiroshima, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi : Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation, American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.299, No.5, G1106-G1117, 2010.
欧文冊子 ● Ahmad Azlina, Purevjav Javkhlan, Yuka Hiroshima, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi : Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation, American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.299, No.5, G1106-G1117, 2010.

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