『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=219713EID:219713, Map:0, LastModified:2015年8月27日(木) 12:31:49, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[池田 康将], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
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著者 (必須): 1.八木 秀介 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域医療人材育成(医学域)])
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2.粟飯原 賢一 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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3.池田 康将 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学]/[徳島大学.医学部.医学科.病態情報医学講座.薬理学分野]/[徳島大学.医科学教育部.医学専攻.病態情報医学講座]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学])
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[継承]
4. (英) Sumitomo Yuka (日) (読)
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[継承]
5.吉田 守美子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.血液・内分泌代謝内科学])
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6. (英) Ise Takayuki (日) (読)
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7.岩瀬 俊
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8. (英) Ishikawa Kazue (日) (読)
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9. (英) Azuma Hiroyuki (日) (読)
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10. (英) Akaike Masashi (日) (読)
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11. (英) Matsumoto Toshio (日) (読)
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題名 (必須): (英) Pitavastatin, an HMG-CoA reductase inhibitor, exerts eNOS-independent protective actions against angiotensin II induced cardiovascular remodeling and renal insufficiency.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Angiotensin II (Ang II) plays a pivotal role in cardiovascular remodeling leading to hypertension, myocardial infarction, and stroke. Pitavastatin, an HMG-CoA reductase inihibitor, is known to have pleiotropic actions against the development of cardiovascular remodeling. The objectives of this study were to clarify the beneficial effects as well as the mechanism of action of pitavastatin against Ang II-induced organ damage. C57BL6/J mice at 10 weeks of age were infused with Ang II for 2 weeks and were simultaneously administered pitavastatin or a vehicle. Pitavastatin treatment improved Ang II-induced left ventricular hypertrophy and diastolic dysfunction and attenuated enhancement of cardiac fibrosis, cardiomyocyte hypertrophy, coronary perivascular fibrosis, and medial thickening. Ang II-induced oxidative stress, cardiac TGFbeta-1 expression, and Smad 2/3 phosphorylation were all attenuated by pitavastatin treatment. Pitavastatin also reduced Ang II-induced cardiac remodeling and diastolic dysfunction in eNOS-/- mice as in wild-type mice. In eNOS-/- mice, the Ang II-induced cardiac oxidative stress and TGF-beta-Smad 2/3 signaling pathway were enhanced, and pitavastatin treatment attenuated the enhanced oxidative stress and the signaling pathway. Moreover, pitavastatin treatment reduced the high mortality rate and improved renal insufficiency in Ang II-treated eNOS-/- mice, with suppression of glomerular oxidative stress and TGF-beta-Smad 2/3 signaling pathway. In conclusion, pitavastatin exerts eNOS-independent protective actions against Ang II-induced cardiovascular remodeling and renal insufficiency through inhibition of the TGF-beta-Smad 2/3 signaling pathway by suppression of oxidative stress.  (日)    [継承]
キーワード (推奨): 1. (英) Angiotensin II (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cardiotonic Agents (日) (読) [継承]
4. (英) Hydroxymethylglutaryl-CoA Reductase Inhibitors (日) (読) [継承]
5. (英) Hypertrophy, Left Ventricular (日) (読) [継承]
6. (英) Mice (日) (読) [継承]
7. (英) Mice, Inbred C57BL (日) (読) [継承]
8. (英) Mice, Knockout (日) (読) [継承]
9. (英) Nitric Oxide Synthase Type III (日) (読) [継承]
10. (英) Oxidative Stress (日) (読) [継承]
11. (英) Quinolines (日) (読) [継承]
12. (英) Renal Insufficiency (日) (読) [継承]
13. (英) Signal Transduction (日) (読) [継承]
14. (英) Smad2 Protein (日) (読) [継承]
15. (英) Smad3 Protein (日) (読) [継承]
16. (英) Transforming Growth Factor beta (日) (読) [継承]
17. (英) Ventricular Remodeling (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Circulation Research ([American Heart Association])
(pISSN: 0009-7330, eISSN: 1524-4571)

ISSN (任意): 1524-4571
ISSN: 0009-7330 (pISSN: 0009-7330, eISSN: 1524-4571)
Title: Circulation research
Title(ISO): Circ Res
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2007年 10月 25日 (平成 19年 10月 25日) [継承]
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DOI (任意): 10.1161/CIRCRESAHA.107.163493    (→Scopusで検索) [継承]
PMID (任意): 17967781    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shusuke Yagi, Ken-ichi Aihara, Yasumasa Ikeda, Yuka Sumitomo, Sumiko Yoshida, Takayuki Ise, Takashi Iwase, Kazue Ishikawa, Hiroyuki Azuma, Masashi Akaike and Toshio Matsumoto : Pitavastatin, an HMG-CoA reductase inhibitor, exerts eNOS-independent protective actions against angiotensin II induced cardiovascular remodeling and renal insufficiency., Circulation Research, Vol.102, No.1, 68-76, 2007.
欧文冊子 ● Shusuke Yagi, Ken-ichi Aihara, Yasumasa Ikeda, Yuka Sumitomo, Sumiko Yoshida, Takayuki Ise, Takashi Iwase, Kazue Ishikawa, Hiroyuki Azuma, Masashi Akaike and Toshio Matsumoto : Pitavastatin, an HMG-CoA reductase inhibitor, exerts eNOS-independent protective actions against angiotensin II induced cardiovascular remodeling and renal insufficiency., Circulation Research, Vol.102, No.1, 68-76, 2007.

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