『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=219673EID:219673, Map:0, LastModified:2017年4月15日(土) 20:13:15, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[池田 康将], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.粟飯原 賢一 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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2.東 博之
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3.池田 康将 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学]/[徳島大学.医学部.医学科.病態情報医学講座.薬理学分野]/[徳島大学.医科学教育部.医学専攻.病態情報医学講座]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学])
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4.赤池 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
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5.安倍 正博 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.血液・内分泌代謝内科学])
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6. (英) Sugihara Takashi (日) (読)
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7.松本 俊夫
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題名 (必須): (英) Successful combination therapy--flunarizine,pentoxifylline, and cholestyramine--for spur cell anemia  (日)    [継承]
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要約 (任意): (英) Spur cell anemia, a hemolytic anemia observed in patients with alcoholic cirrhosis, is characterized by unusual erythrocyte morphology and an increased ratio of free cholesterol to phospholipid in the erythrocyte membrane. The prognosis of spur cell anemia is usually extremely poor, however, we describe here a patient with spur cell anemia who was successfully treated with combination therapy consisting of flunarizine, pentoxifylline, and cholestyramine. Initial therapy with flunarizine alone for 6 weeks did not significantly decrease the number of spur cells on peripheral blood smears. So pentoxifylline was added to the regimen. The patient recovered from the anemia, showed remarkable improvement with regard to the hyperbilirubinemia, and the changes were accompanied by a significant decrease in the number of spur cells in peripheral blood smears. To correct the hypercholesterolemia, cholestyramine was added to the regimen, which resulted in a reduction in the serum level of free cholesterol and an increase in the molar ratio of free cholesterol to phospholipid in erythrocyte membrane. However, 6 months later a skin eruption developed that was considered an adverse reaction to the drugs, so the flunarizine and pentoxifylline were discontinued. With cholestyramine therapy alone, the remission of spur cell anemia was maintained for more than 11 months. These observations suggest that non-invasive combination therapy with flunarizine, pentoxifylline, and cholestyramine is effective and valuable in the treatment of patients with spur cell anemia.  (日)    [継承]
キーワード (推奨): 1. (英) Spur cell anemia (日) (読) [継承]
2. (英) Free cholesterol (日) (読) [継承]
3. (英) Hepatosplenomegaly (日) (読) [継承]
4. (英) Pentoxifylline (日) (読) [継承]
5. (英) Cholestyramine (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Hematology (日本血液学会)
(pISSN: 0925-5710, eISSN: 1865-3774)

ISSN (任意): 0925-5710
ISSN: 0925-5710 (pISSN: 0925-5710, eISSN: 1865-3774)
Title: International journal of hematology
Title(ISO): Int J Hematol
Publisher: Springer Japan
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 73 [継承]
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(必須): 351 355 [継承]
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年月日 (必須): 西暦 2001年 4月 初日 (平成 13年 4月 初日) [継承]
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PMID (任意): 11345202    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Case Reports  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Ken-ichi Aihara, Hiroyuki Azuma, Yasumasa Ikeda, Masashi Akaike, Masahiro Abe, Takashi Sugihara and Toshio Matsumoto : Successful combination therapy--flunarizine,pentoxifylline, and cholestyramine--for spur cell anemia, International Journal of Hematology, Vol.73, No.3, 351-355, 2001.
欧文冊子 ● Ken-ichi Aihara, Hiroyuki Azuma, Yasumasa Ikeda, Masashi Akaike, Masahiro Abe, Takashi Sugihara and Toshio Matsumoto : Successful combination therapy--flunarizine,pentoxifylline, and cholestyramine--for spur cell anemia, International Journal of Hematology, Vol.73, No.3, 351-355, 2001.

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