| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Sumitomo-Ueda Yuka (日) (読)
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| 2. | 粟飯原 賢一 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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| 3. | (英) Ise Takayuki (日) (読)
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| 4. | 吉田 守美子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.血液・内分泌代謝内科学])
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| 5. | 池田 康将 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学]/[徳島大学.医学部.医学科.病態情報医学講座.薬理学分野]/[徳島大学.医科学教育部.医学専攻.病態情報医学講座]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学])
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| 6. | (英) Uemoto Ryoko (日) (読)
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| 7. | 八木 秀介 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域医療人材育成(医学域)])
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| 8. | 岩瀬 俊
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| 9. | (英) Ishikawa Kazue (日) (読)
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| 10. | (英) Hirata Yoichiro (日) (読)
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| 11. | 赤池 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
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| 12. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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| 13. | (英) Kato Shigeaki (日) (読)
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| 14. | 松本 俊夫
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| ○題名 (必須): | □ | (英) Heparin cofactor II protects against angiotensin II-induced cardiac remodeling via attenuation of oxidative stress in mice. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Heparin cofactor II (HCII), a serine protease inhibitor, inhibits tissue thrombin action after binding with dermatan sulfate proteoglycans in the extracellular matrix of the vascular system. We previously reported that heterozygous HCII-deficient (HCII(+/-)) humans and mice demonstrate acceleration of vascular remodeling, including atherosclerosis. However, the action of HCII on cardiac remodeling never has been determined. HCII(+/+) and HCII(+/-) mice at age 25 weeks were infused with angiotensin II (Ang II; 2.0 mg/kg/d) for 2 weeks by an osmotic mini-pump. Echocardiography revealed acceleration of cardiac concentric remodeling in HCII(+/-) mice and larger left atrial volume in HCII(+/-) mice than in HCII(+/+) mice. Histopathologic studies showed more prominent interstitial fibrosis in both the left atrium and left ventricle in HCII(+/-) mice than in HCII(+/+) mice. Daily urinary excretion of 8-hydroxy-2'-deoxyguanosine, a parameter of oxidative stress, and dihydroethidium-positive spots, indicating superoxide production in the myocardium, were markedly increased in Ang II-treated HCII(+/-) mice compared to those in HCII(+/+) mice. Cardiac gene expression levels of atrial natriuretic peptides and brain natriuretic peptides, members of the natriuretic peptide family, Nox 4, Rac-1, and p67(phox) as components of NAD(P)H oxidase, and transforming growth factor-beta1 and procollagen III were more augmented in HCII(+/-) mice than in HCII(+/+) mice. However, administration of human HCII protein attenuated all of those abnormalities in Ang II-treated HCII(+/-) mice. Moreover, human HCII protein supplementation almost abolished cardiac fibrosis in Ang II-treated HCII(+/+) mice. The results indicate that HCII has a protective role against Ang II-induced cardiac remodeling through suppression of the NAD(P)H oxidase-transforming growth factor-beta1 pathway. (日)
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| ○キーワード (推奨): | 1. | (英) Analysis of Variance (日) (読)
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| 2. | (英) Angiotensin II (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) Atrial Natriuretic Factor (日) (読)
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| 5. | (英) Cardiomegaly (日) (読)
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| 6. | (英) Echocardiography (日) (読)
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| 7. | (英) Fibrosis (日) (読)
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| 8. | (英) Heart Atria (日) (読)
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| 9. | (英) Heparin Cofactor II (日) (読)
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| 10. | (英) Mice (日) (読)
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| 11. | (英) Mice, Transgenic (日) (読)
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| 12. | (英) Myocardium (日) (読)
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| 13. | (英) Natriuretic Peptide, Brain (日) (読)
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| 14. | (英) Oxidative Stress (日) (読)
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| 15. | (英) Transforming Growth Factor beta1 (日) (読)
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| 16. | (英) Ventricular Remodeling (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Hypertension ([American Heart Association])
(pISSN: 0194-911X, eISSN: 1524-4563)
| ○ISSN (任意): | □ | 1524-4563
ISSN: 0194-911X
(pISSN: 0194-911X, eISSN: 1524-4563) Title: Hypertension (Dallas, Tex. : 1979)Title(ISO): HypertensionPublisher: American Heart Association (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 56
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 430 436
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2010年 7月 26日 (平成 22年 7月 26日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1161/HYPERTENSIONAHA.110.152207 (→Scopusで検索)
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| ○PMID (任意): | □ | 20660821 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Affiliation: Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. (日)
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| 2. | (英) PublicationType: Journal Article (日)
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| 3. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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