『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Zhang Kai (日) (読)
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2. (英) Watanabe Masami (日) (読)
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3. (英) Kashiwakura Yuji (日) (読)
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4. (英) Li Shun-Ai (日) (読)
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5. (英) Edamura Kohei (日) (読)
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6. (英) Huang Peng (日) (読)
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7. (英) Yamaguchi Ken (日) (読)
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8. (英) Nasu Yasutomo (日) (読)
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9. (英) Kobayashi Yasuyuki (日) (読)
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10. (英) Sakaguchi Masakiyo (日) (読)
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11.落合 和彦
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12. (英) Yamada Hiroshi (日) (読)
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13. (英) Takei Kohji (日) (読)
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14. (英) Ueki Hideo (日) (読)
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15. (英) Huh Nam-Ho (日) (読)
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16. (英) Li Ming (日) (読)
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17. (英) Kaku Haruki (日) (読)
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18. (英) Na Yanqun (日) (読)
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19. (英) Kumon Hiromi (日) (読)
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題名 (必須): (英) Expression pattern of REIC/Dkk-3 in various cell types and the implications of the soluble form in prostatic acinar development.  (日)    [継承]
副題 (任意):
要約 (任意): (英)   (日) The tumor suppressor REIC/Dkk-3 is a secretory protein which was originally identified to be downregulated in human immortalized cells. In the present study, we investigated the expression pattern of REIC/Dkk-3 in various cell types to characterize its physiological functions. We first examined the expression level of REIC/Dkk-3 in a broad range of cancer cell types and confirmed that it was significantly downregulated in all of the cell types. We also examined the tissue distribution pattern in a variety of normal mouse organs. Ubiquitous REIC/Dkk-3 protein expression was observed in the organs. The expression was abundant in the liver, heart and brain tissue, but was absent in the spleen and peripheral blood mononuclear cells. The immunohistochemical analyses revealed that the subcellular localization of REIC/Dkk-3 had a punctate pattern around the nucleus, indicating its association with secretory vesicles. In cancer cells stably transfected with REIC/Dkk-3, the protein was predominantly localized to the endoplasmic reticulum (ER) under observation with confocal microscopy. Because REIC/Dkk-3 was found to be abundantly expressed in the acinar epithelial cells of the mouse prostate, we analyzed the effects of recombinant REIC/Dkk-3 protein on the acinar morphogenesis of RWPE-1 cells, which are derived from human normal prostate epithelium. Statistically significant acinar growth was observed in the culture condition with 10 µg/ml REIC/Dkk-3 protein, implicating the soluble form in prostatic acinar development. Current results suggest that REIC/Dkk-3 may play a role in regulating the morphological process of normal tissue architecture through an autocrine and/or paracrine manner.   [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Autocrine Communication (日) (読) [継承]
3.細胞 (cells/->キーワード[細胞]) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5. (英) Gene Expression Profiling (日) (読) [継承]
6. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
7. (英) Hela Cells (日) (読) [継承]
8. (英) Hep G2 Cells (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Intercellular Signaling Peptides and Proteins (日) (読) [継承]
11. (英) Male (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Inbred C57BL (日) (読) [継承]
14.形態形成 (morphogenesis) [継承]
15. (英) Organ Specificity (日) (読) [継承]
16. (英) Prostate (日) (読) [継承]
17.溶解度 (solubility) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Oncology (International Center for Cancer Research)
(pISSN: 1019-6439, eISSN: 1791-2423)

ISSN (任意): 1791-2423
ISSN: 1019-6439 (pISSN: 1019-6439, eISSN: 1791-2423)
Title: International journal of oncology
Title(ISO): Int J Oncol
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1495 1501 [継承]
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年月日 (必須): 西暦 2010年 12月 初日 (平成 22年 12月 初日) [継承]
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DOI (任意): 10.3892/ijo_00000802    (→Scopusで検索) [継承]
PMID (任意): 21042718    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Innovation Center Okayama for Nanobio-Targeted Therapy, Okayama University, Okayama, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kai Zhang, Masami Watanabe, Yuji Kashiwakura, Shun-Ai Li, Kohei Edamura, Peng Huang, Ken Yamaguchi, Yasutomo Nasu, Yasuyuki Kobayashi, Masakiyo Sakaguchi, Kazuhiko Ochiai, Hiroshi Yamada, Kohji Takei, Hideo Ueki, Nam-Ho Huh, Ming Li, Haruki Kaku, Yanqun Na and Hiromi Kumon : Expression pattern of REIC/Dkk-3 in various cell types and the implications of the soluble form in prostatic acinar development., International Journal of Oncology, Vol.37, No.6, 1495-1501, 2010.
欧文冊子 ● Kai Zhang, Masami Watanabe, Yuji Kashiwakura, Shun-Ai Li, Kohei Edamura, Peng Huang, Ken Yamaguchi, Yasutomo Nasu, Yasuyuki Kobayashi, Masakiyo Sakaguchi, Kazuhiko Ochiai, Hiroshi Yamada, Kohji Takei, Hideo Ueki, Nam-Ho Huh, Ming Li, Haruki Kaku, Yanqun Na and Hiromi Kumon : Expression pattern of REIC/Dkk-3 in various cell types and the implications of the soluble form in prostatic acinar development., International Journal of Oncology, Vol.37, No.6, 1495-1501, 2010.

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