○種別 (必須): | □ | 学術論文 (審査論文)
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○言語 (必須): | □ | 英語
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○招待 (推奨): |
○審査 (推奨): | □ | Peer Review
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○カテゴリ (推奨): |
○共著種別 (推奨): |
○学究種別 (推奨): |
○組織 (推奨): | 1. | 徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学 (2004年4月1日〜)
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| 2. | 徳島大学.病院.診療科.矯正歯科 (2003年10月1日〜)
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| 3. | 徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.顎口腔再建医学講座.口腔顎顔面矯正学 (2004年4月1日〜2015年3月31日)
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○著者 (必須): | 1. | 中村 竜也 ([徳島大学.口腔科学教育部.口腔科学専攻.口腔健康科学講座.口腔顎顔面矯正学])
○役割 (任意): |
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○学籍番号 (推奨): |
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| 2. | 藤原 慎視
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| 3. | 桂 智子
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| 4. | (英) Yamamoto Kumiko (日) 山本 久美子 (読) やまもと くみこ
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| 5. | (英) Inubushi Toshihiro (日) (読)
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| 6. | 谷本 幸太郎 ([広島大学])
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| 7. | 田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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○題名 (必須): | □ | (英) Effects of low-intensity pulsed ultrasound on the expression and activity of hyaluronan synthase and hyaluronidase in IL-1β-stimulated synovial cells. (日)
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○副題 (任意): |
○要約 (任意): | □ | (英) The purpose of this study is to examine effects of low-intensity pulsed ultrasound (LIPUS) on metabolism of hyaluronan (HA) in synovial membrane cells stimulated by IL-1β. Rabbit knee synovial membrane cell line, HIG-82, was cultured in medium with the presence or absence of 1 ng/mL IL-1β, and after 4 h the cell was exposed to LIPUS for 15 min. The mRNA levels of HA synthase (HAS) 2,3, hyaluronidase (HYAL) 2, and cyclooxygenase (COX)-2 were examined by real-time PCR analysis. Concentrations of HA and PGE2 were quantified by use of enzyme linked immunosorbent assay (ELISA). The COX-2 level was analyzed by western blotting. Gene levels of HAS2 and HAS3 in IL-1β-stimulated cells were up-regulated significantly (p < 0.01) by LIPUS. HYAL2 mRNA was up-regulated by the treatment with IL-1β, whereas down-regulated significantly (p < 0.01) by the following LIPUS exposure. Furthermore, IL-1β stimulation enhanced COX-2 and PGE2 expression as compared to the untreated control, and IL-1β-induced COX-2 and PGE2 expression was inhibited by LIPUS. These results suggest that LIPUS enhanced HA synthesis and inhibited HYAL2 expression, leading to the accumulation of high-molecular weight HA. Therefore, LIPUS stimulation may be a better candidate as medical remedy to treat inflammatory joint diseases accompanied with HA degradation in synovial fluid. (日)
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○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Arthritis (日) (読)
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| 3. | (英) Cell Line (日) (読)
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| 4. | (英) Cyclooxygenase 2 (日) (読)
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| 5. | (英) Dinoprostone (日) (読)
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| 6. | (英) Gene Expression Regulation (日) (読)
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| 7. | (英) Glucuronosyltransferase (日) (読)
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| 8. | (英) Hyaluronoglucosaminidase (日) (読)
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| 9. | (英) Interleukin-1beta (日) (読)
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| 10. | (英) Knee Joint (日) (読)
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| 11. | (英) Rabbits (日) (読)
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| 12. | (英) Sound (日) (読)
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| 13. | (英) Synovial Membrane (日) (読)
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| 14. | (英) Time Factors (日) (読)
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| 15. | (英) Ultrasonic Therapy (日) (読)
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| 16. | (英) Up-Regulation (日) (読)
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○発行所 (推奨): |
○誌名 (必須): | □ | Annals of Biomedical Engineering (Biomedical Engineering Society (BMES).)
(pISSN: 0090-6964, eISSN: 1573-9686)
○ISSN (任意): | □ | 1573-9686
ISSN: 0090-6964
(pISSN: 0090-6964, eISSN: 1573-9686) Title: Annals of biomedical engineeringTitle(ISO): Ann Biomed EngSupplier: Kluwer OnlinePublisher: Springer US (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login])
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○巻 (必須): | □ | 38
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○号 (必須): | □ | 11
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○頁 (必須): | □ | 3363 3370
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○都市 (任意): |
○年月日 (必須): | □ | 西暦 2010年 11月 末日 (平成 22年 11月 末日)
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○URL (任意): |
○DOI (任意): | □ | 10.1007/s10439-010-0104-5 (→Scopusで検索)
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○PMID (任意): | □ | 20571855 (→Scopusで検索)
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○NAID (任意): |
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○Scopus (任意): | □ | 2-s2.0-78149285438
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○備考 (任意): | 1. | (英) Affiliation: Department of Orthodontics and Dentofacial Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan. (日)
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| 2. | (英) Publicationtype: Journal Article (日)
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