『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=215493EID:215493, Map:0, LastModified:2013年5月19日(日) 19:01:49, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[佐藤 陽一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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著者 (必須): 1.佐藤 陽一 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品情報学])
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2. (英) Kosioka Sakura (日) (読)
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3. (英) Kirino Yasushi (日) (読)
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4. (英) Kamimoto Takayuki (日) (読)
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5.川添 和義
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6.阿部 真治 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.総合薬学教育学系.臨床薬学実務教育学])
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7.水口 和生
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8.中堀 豊
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題名 (必須): (英) Role of dipeptidyl peptidase IV (DPP4) in the development of dyslipidemia: DPP4 contributes to the steroid metabolism pathway.  (日)    [継承]
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要約 (任意): (英) We previously reported that dipeptidyl peptidase IV (DPP4)-deficient rats were susceptible to dyslipidemia induced by streptozotocin (STZ). Hence, it is suggested that DPP4 is important for lipid metabolism. In this study, to verify the role of DPP4 in the development of dyslipidemia, we carried out a microarray analysis of the livers of STZ-treated wild-type and DPP4-deficient rats and showed that the expression levels of genes involved in metabolic processes (steroid metabolic processes and cellular lipid metabolic processes) were significantly altered by STZ treatment. In the wild-type rats, the expression of hydroxysteroid (17-beta) dehydrogenase 2 (Hsd7b2), which catalyzes sex steroid synthesis from cholesterol, was significantly increased by about 15-fold after STZ treatment; however, it did not change in the DPP4-deficient rats. In the STZ untreated group of DPP4-deficient rats, the expression levels of cytochrome P450, subfamily 51 (Cyp51) and sterol-C4-methyl oxidase-like (Sc4mol), which catalyze intermediate steps in cholesterol synthesis, were significantly elevated compared to those of other groups. Similar results were demonstrated in HuH7-cells after DPP4 overexpression or the addition of human sera containing DPP4. DPP4 is crucial for regulating the expression of factors related to steroid metabolism such as Cyp51, Sc4mol, and Hsd17b2, and DPP4 deficiency or inhibition may cause dyslipidemia.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Line (日) (読) [継承]
3. (英) Cholesterol (日) (読) [継承]
4. (英) Dipeptidyl Peptidase 4 (日) (読) [継承]
5. (英) Dyslipidemias (日) (読) [継承]
6. (英) Estradiol Dehydrogenases (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Lipid Metabolism (日) (読) [継承]
9. (英) Liver (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Oligonucleotide Array Sequence Analysis (日) (読) [継承]
12. (英) Rats (日) (読) [継承]
13. (英) Rats, Inbred F344 (日) (読) [継承]
14. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
15. (英) Sterol 14-Demethylase (日) (読) [継承]
16. (英) Streptozocin (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Life Sciences ([Elsevier])
(pISSN: 0024-3205, eISSN: 1879-0631)

ISSN (任意): 1879-0631
ISSN: 0024-3205 (pISSN: 0024-3205, eISSN: 1879-0631)
Title: Life sciences
Title(ISO): Life Sci
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 43 49 [継承]
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年月日 (必須): 西暦 2011年 0月 初日 (平成 23年 0月 初日) [継承]
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DOI (任意): 10.1016/j.lfs.2010.10.019    (→Scopusで検索) [継承]
PMID (任意): 21047519    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pharmaceutical Information Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan. sato@ph.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Youichi Sato, Sakura Kosioka, Yasushi Kirino, Takayuki Kamimoto, Kazuyoshi Kawazoe, Shinji Abe, Kazuo Minakuchi and Yutaka Nakahori : Role of dipeptidyl peptidase IV (DPP4) in the development of dyslipidemia: DPP4 contributes to the steroid metabolism pathway., Life Sciences, Vol.88, No.1-2, 43-49, 2011.
欧文冊子 ● Youichi Sato, Sakura Kosioka, Yasushi Kirino, Takayuki Kamimoto, Kazuyoshi Kawazoe, Shinji Abe, Kazuo Minakuchi and Yutaka Nakahori : Role of dipeptidyl peptidase IV (DPP4) in the development of dyslipidemia: DPP4 contributes to the steroid metabolism pathway., Life Sciences, Vol.88, No.1-2, 43-49, 2011.

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