『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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学究種別 (推奨):
組織 (推奨): 1.徳島大学 [継承]
著者 (必須): 1.武藤 太郎
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2.三好 圭子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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3. (英) Munesue Seiichi (日) (読)
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[継承]
4. (英) Nakada Hiroshi (日) (読)
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[継承]
5. (英) Okayama Minoru (日) (読)
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[継承]
6.松尾 敬志
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7.野間 隆文 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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題名 (必須): (英) Differential expression of syndecan isoforms during mouse incisor amelogenesis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Syndecans are transmembranous heparan sulfate proteoglycans (HSPGs) with covalently attached glycosaminoglycan side-chains located on the cell surface. The mammalian syndecan family is composed of four types of syndecans (syndecan-1 to -4). Syndecans interact with the intracellular cytoskeleton through the cytoplasmic domains of their core proteins and membrane proteins, extracellular enzymes, growth factors, and matrix components, through their heparan-sulfate chains, to regulate developmental processes.Here, as a first step to assess the possible roles of syndecan proteins in amelogenesis, we examined the expression patterns of all syndecan isoforms in continuously growing mouse incisors, in which we can overview major differentiation stages of amelogenesis at a glance. Understanding the expression domain of each syndecan isoform during specific developmental stages seems useful for investigating their physiological roles in amelogenesis. Immunohistochemical analysis of syndecan core proteins in the lower incisors from postnatal day 1 mice revealed spatially and temporally specific expression patterns, with syndecan-1 expressed in undifferentiated epithelial and mesenchymal cells, and syndecan-2, -3, and -4 in more differentiated cells. These findings suggest that each syndecan isoform functions distinctly during the amelogenesis of the incisors of mice.  (日)    [継承]
キーワード (推奨): 1. (英) Amelogenesis (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Animals, Newborn (日) (読) [継承]
4. (英) Base Sequence (日) (読) [継承]
5. (英) DNA Primers (日) (読) [継承]
6. (英) Gene Expression Regulation, Developmental (日) (読) [継承]
7.免疫組織化学 (immunohistochemistry) [継承]
8. (英) Incisor (日) (読) [継承]
9.ノックアウトマウス (knockout mice) [継承]
10. (英) Mice, Inbred ICR (日) (読) [継承]
11. (英) Protein Isoforms (日) (読) [継承]
12. (英) Syndecans (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 54 [継承]
(必須): 3-4 [継承]
(必須): 331 339 [継承]
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年月日 (必須): 西暦 2007年 8月 初日 (平成 19年 8月 初日) [継承]
URL (任意):
DOI (任意): 10.2152/jmi.54.331    (→Scopusで検索) [継承]
PMID (任意): 17878683    (→Scopusで検索) [継承]
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機関リポジトリ : 111537 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Molecular Biology, The University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Taro Muto, Keiko Miyoshi, Seiichi Munesue, Hiroshi Nakada, Minoru Okayama, Takashi Matsuo and Takafumi Noma : Differential expression of syndecan isoforms during mouse incisor amelogenesis., The Journal of Medical Investigation : JMI, Vol.54, No.3-4, 331-339, 2007.
欧文冊子 ● Taro Muto, Keiko Miyoshi, Seiichi Munesue, Hiroshi Nakada, Minoru Okayama, Takashi Matsuo and Takafumi Noma : Differential expression of syndecan isoforms during mouse incisor amelogenesis., The Journal of Medical Investigation : JMI, Vol.54, No.3-4, 331-339, 2007.

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