| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 池原 敏孝 ([徳島文理大学])
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| 2. | (英) Nishisako Hirotaka (日) (読)
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| 3. | (英) Minami Yuki (日) (読)
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| 4. | (英) Ichinose Sasaki Hiromi (日) (読)
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| 5. | (英) Shiraishi Tairo (日) (読)
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| 6. | 北村 光夫 ([徳島大学.技術支援部])
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| 7. | 庄野 正行 ([徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター])
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| 8. | 芳地 一
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| 9. | 川添 和義
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| 10. | 水口 和生
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| 11. | 吉﨑 和男
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| 12. | 木内 陽介
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| 13. | 宮本 博司 ([徳島文理大学])
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| ○題名 (必須): | □ | (英) Effects of exposure to a time-varying 1.5T magnetic field on the neurotransmitter-activated increase in intracellular Ca(2+) in relation to actin fiber and mitochondrial functions in bovine adrenal chromaffin cells. (日)
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| ○要約 (任意): | □ | (英) BACKGROUND: It has been reported that exposure to electromagnetic fields influences intracellular signal transduction. We studied the effects of exposure to a time-varying 1.5T magnetic field on membrane properties, membrane cation transport and intracellular Ca(2+) mobilization in relation to signals. We also studied the mechanism of the effect of exposure to the magnetic field on intracellular Ca(2+) release from Ca(2+) stores in adrenal chromaffin cells. METHODS: We measured the physiological functions of ER, actin protein, and mitochondria with respect to a neurotransmitter-induced increase in Ca(2+) in chromaffin cells exposed to the time-varying 1.5T magnetic field for 2h. RESULTS: Exposure to the magnetic field significantly reduced the increase in [Ca(2+)]i. The exposure depolarized the mitochondria membrane and lowered oxygen uptake, but did not reduce the intracellular ATP content. Magnetic field-exposure caused a morphological change in intracellular F-actin. F-actin in exposed cells seemed to be less dense than in control cells, but the decrease was smaller than that in cytochalasin D-treated cells. The increase in G-actin (i.e., the decrease in F-actin) due to exposure was recovered by jasplakinolide, but inhibition of Ca(2+) release by the exposure was unaffected. CONCLUSIONS AND GENERAL SIGNIFICANCE: These results suggest that the magnetic field-exposure influenced both the ER and mitochondria, but the inhibition of Ca(2+) release from ER was not due to mitochondria inhibition. The effect of eddy currents induced in the culture medium may indirectly influence intracellular actin and suppress the transient increase in [Ca(2+)]i. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Biochimica et Biophysica Acta (BBA) - General Subjects ([Elsevier Science])
(pISSN: 0304-4165)
| ○ISSN (任意): | □ | 0304-4165
ISSN: 0304-4165
(pISSN: 0304-4165, eISSN: 1872-8006) Title: Biochimica et biophysica acta. General subjectsTitle(ISO): Biochim Biophys Acta Gen SubjPublisher: Elsevier BV (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 1800
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| ○号 (必須): | □ | 12
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| ○頁 (必須): | □ | 1221 1230
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2010年 9月 9日 (平成 22年 9月 9日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bbagen.2010.09.001 (→Scopusで検索)
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| ○PMID (任意): | □ | 20832450 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Human Welfare, Faculty of Health and Welfare, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan; Department of Physiology, Institute of Health BioSciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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