『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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言語 (必須): 英語 [継承]
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著者 (必須): 1.池原 敏孝 ([徳島文理大学])
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2. (英) Nishisako Hirotaka (日) (読)
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3. (英) Minami Yuki (日) (読)
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4. (英) Ichinose Sasaki Hiromi (日) (読)
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5. (英) Shiraishi Tairo (日) (読)
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6.北村 光夫 ([徳島大学.技術支援部])
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7.庄野 正行 ([徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター])
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8.芳地 一
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9.川添 和義
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10.水口 和生
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11.吉﨑 和男
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12.木内 陽介
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13.宮本 博司 ([徳島文理大学])
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題名 (必須): (英) Effects of exposure to a time-varying 1.5T magnetic field on the neurotransmitter-activated increase in intracellular Ca(2+) in relation to actin fiber and mitochondrial functions in bovine adrenal chromaffin cells.  (日)    [継承]
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要約 (任意): (英) BACKGROUND: It has been reported that exposure to electromagnetic fields influences intracellular signal transduction. We studied the effects of exposure to a time-varying 1.5T magnetic field on membrane properties, membrane cation transport and intracellular Ca(2+) mobilization in relation to signals. We also studied the mechanism of the effect of exposure to the magnetic field on intracellular Ca(2+) release from Ca(2+) stores in adrenal chromaffin cells. METHODS: We measured the physiological functions of ER, actin protein, and mitochondria with respect to a neurotransmitter-induced increase in Ca(2+) in chromaffin cells exposed to the time-varying 1.5T magnetic field for 2h. RESULTS: Exposure to the magnetic field significantly reduced the increase in [Ca(2+)]i. The exposure depolarized the mitochondria membrane and lowered oxygen uptake, but did not reduce the intracellular ATP content. Magnetic field-exposure caused a morphological change in intracellular F-actin. F-actin in exposed cells seemed to be less dense than in control cells, but the decrease was smaller than that in cytochalasin D-treated cells. The increase in G-actin (i.e., the decrease in F-actin) due to exposure was recovered by jasplakinolide, but inhibition of Ca(2+) release by the exposure was unaffected. CONCLUSIONS AND GENERAL SIGNIFICANCE: These results suggest that the magnetic field-exposure influenced both the ER and mitochondria, but the inhibition of Ca(2+) release from ER was not due to mitochondria inhibition. The effect of eddy currents induced in the culture medium may indirectly influence intracellular actin and suppress the transient increase in [Ca(2+)]i.  (日)    [継承]
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誌名 (必須): Biochimica et Biophysica Acta (BBA) - General Subjects ([Elsevier Science])
(pISSN: 0304-4165)

ISSN (任意): 0304-4165
ISSN: 0304-4165 (pISSN: 0304-4165, eISSN: 1872-8006)
Title: Biochimica et biophysica acta. General subjects
Title(ISO): Biochim Biophys Acta Gen Subj
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1800 [継承]
(必須): 12 [継承]
(必須): 1221 1230 [継承]
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年月日 (必須): 西暦 2010年 9月 9日 (平成 22年 9月 9日) [継承]
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DOI (任意): 10.1016/j.bbagen.2010.09.001    (→Scopusで検索) [継承]
PMID (任意): 20832450    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Human Welfare, Faculty of Health and Welfare, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan; Department of Physiology, Institute of Health BioSciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Toshitaka Ikehara, Hirotaka Nishisako, Yuki Minami, Hiromi Sasaki Ichinose, Tairo Shiraishi, Mitsuo Kitamura, Masayuki Shono, Hitoshi Houchi, Kazuyoshi Kawazoe, Kazuo Minakuchi, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Effects of exposure to a time-varying 1.5T magnetic field on the neurotransmitter-activated increase in intracellular Ca(2+) in relation to actin fiber and mitochondrial functions in bovine adrenal chromaffin cells., Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1800, No.12, 1221-1230, (発行所), (都市), Sep. 2010.
欧文冊子 ● (種別) : Toshitaka Ikehara, Hirotaka Nishisako, Yuki Minami, Hiromi Sasaki Ichinose, Tairo Shiraishi, Mitsuo Kitamura, Masayuki Shono, Hitoshi Houchi, Kazuyoshi Kawazoe, Kazuo Minakuchi, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Effects of exposure to a time-varying 1.5T magnetic field on the neurotransmitter-activated increase in intracellular Ca(2+) in relation to actin fiber and mitochondrial functions in bovine adrenal chromaffin cells., Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1800, No.12, 1221-1230, (発行所), (都市), Sep. 2010.

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