『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Nakagaki Hidetaka (日) (読)
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[継承]
2. (英) Sekine Shinichi (日) (読)
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[継承]
3. (英) Terao Yutaka (日) (読)
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[継承]
4. (英) Toe Masahiro (日) (読)
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[継承]
5. (英) Tanaka Muneo (日) (読)
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6.伊藤 博夫 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.予防歯学])
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7. (英) Kawabata Shigetada (日) (読)
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8. (英) Shizukuishi Satoshi (日) (読)
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9. (英) Fujihashi Kohtaro (日) (読)
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10.片岡 宏介
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題名 (必須): (英) Fusobacterium nucleatum envelope protein FomA is immunogenic and binds to the salivary statherin-derived peptide.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have previously shown that one of the minimal active regions of statherin, a human salivary protein, for binding to Fusobacterium nucleatum is a YQPVPE amino acid sequence. In this study, we identified the FomA protein of F. nucleatum, which is responsible for binding to the statherin-derived YQPVPE peptide. Overlay analysis showed that a 40-kDa protein of the F. nucleatum cell envelope (40-kDa CE) specifically bound to the YQPVPE peptide. The equilibrium association constant between the affinity-purified 40-kDa CE and the YQPVPE peptide was 4.30 x 10(6). Further, the purity and amino acid sequence analyses of the purified 40-kDa CE revealed approximately 98.7% (wt/wt) purity and a high degree of homology with FomA, a major porin protein of F. nucleatum. Thus, a FomA-deficient mutant failed to bind to the YQPVPE peptide. In addition, increased levels of a FomA-specific mucosal IgA antibody (Ab) and plasma IgG and IgA Abs were seen only in mice immunized nasally with cholera toxin (CT) and the purified 40-kDa FomA protein. Interestingly, saliva from mice that received FomA plus CT as a mucosal adjuvant nasally prevented in vitro binding of F. nucleatum to statherin-coated polyvinyl chloride plates. Taken together, these results suggest that induction of specific immunity to the 40-kDa FomA protein of F. nucleatum, which specifically binds to the statherin-derived peptide, may be an effective tool for preventing the formation of F. nucleatum biofilms in the oral cavity.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Acid Sequence (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antibodies, Bacterial (日) (読) [継承]
4. (英) Bacterial Outer Membrane Proteins (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Fusobacterium nucleatum (日) (読) [継承]
7. (英) Gene Deletion (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Immunoglobulin A (日) (読) [継承]
10. (英) Immunoglobulin G (日) (読) [継承]
11. (英) Kinetics (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Inbred C57BL (日) (読) [継承]
14. (英) Molecular Sequence Data (日) (読) [継承]
15. (英) Molecular Weight (日) (読) [継承]
16. (英) Mucous Membrane (日) (読) [継承]
17. (英) Protein Binding (日) (読) [継承]
18. (英) Protein Interaction Mapping (日) (読) [継承]
19. (英) Salivary Proteins and Peptides (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Infection and Immunity ([アメリカ微生物学会])
(pISSN: 0019-9567, eISSN: 1098-5522)

ISSN (任意): 1098-5522
ISSN: 0019-9567 (pISSN: 0019-9567, eISSN: 1098-5522)
Title: Infection and immunity
Title(ISO): Infect. Immun.
Publisher: American Society for Microbiology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2010年 3月 14日 (平成 22年 3月 14日) [継承]
URL (任意):
DOI (任意): 10.1128/IAI.01224-09    (→Scopusで検索) [継承]
PMID (任意): 20008529    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Preventive Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 770-8504, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]
5.(英) OtherID: PMC2825909 [Available on 09/01/10]  (日)    [継承]

標準的な表示

和文冊子 ● Hidetaka Nakagaki, Shinichi Sekine, Yutaka Terao, Masahiro Toe, Muneo Tanaka, Hiro-O Ito, Shigetada Kawabata, Satoshi Shizukuishi, Kohtaro Fujihashi and Kosuke Kataoka : Fusobacterium nucleatum envelope protein FomA is immunogenic and binds to the salivary statherin-derived peptide., Infection and Immunity, Vol.78, No.3, 1185-1192, 2010.
欧文冊子 ● Hidetaka Nakagaki, Shinichi Sekine, Yutaka Terao, Masahiro Toe, Muneo Tanaka, Hiro-O Ito, Shigetada Kawabata, Satoshi Shizukuishi, Kohtaro Fujihashi and Kosuke Kataoka : Fusobacterium nucleatum envelope protein FomA is immunogenic and binds to the salivary statherin-derived peptide., Infection and Immunity, Vol.78, No.3, 1185-1192, 2010.

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