| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Fukuiwa Tatsuya (日) (読)
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| 2. | (英) Sekine Shinichi (日) (読)
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| 3. | (英) Kobayashi Ryoki (日) (読)
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| 4. | (英) Suzuki Hideaki (日) (読)
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| 5. | 片岡 宏介 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健福祉学]/徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.歯学系.予防歯学令和6年4月より併任)
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| 6. | (英) Gilbert S. Rebekah (日) (読)
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| 7. | (英) Kurono Yuichi (日) (読)
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| 8. | (英) Boyaka N. Prosper (日) (読)
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| 9. | (英) Krieg M. Arthur (日) (読)
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| 10. | (英) McGhee R. Jerry (日) (読)
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| 11. | (英) Fujihashi Kohtaro (日) (読)
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| ○題名 (必須): | □ | (英) A combination of Flt3 Ligand cDNA and CpG ODN as nasal adjuvants elicits NALT dendritic cells for prolonged mucosal immunity. (日)
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| ○要約 (任意): | □ | (英) We explore cellular and molecular mechanisms of nasal adjuvant of a combination of a plasmid encoding the Flt3 ligand cDNA (pFL) and CpG oligodeoxynucleotides (CpG ODN). The double DNA adjuvant given with OVA maintained prolonged OVA-specific secretory IgA (S-IgA) Ab responses in external secretions for more than 25 weeks after the final immunization. Further, both Th1- and Th2-type cytokine responses were induced by this combined adjuvant regimen. The frequencies of plasmacytoid DCs (pDCs) and CD8(+) DCs were significantly increased in nasopharyngeal-associated lymphoreticular tissue (NALT) of mice given the combined adjuvant. Importantly, when we examined adjuvanticity of pFL plus CpG ODN in 2-year-old mice, significant levels of mucosal IgA Ab responses were also induced. These results demonstrate that nasal delivery of a combined DNA adjuvant offers an attractive possibility for the development of an effective mucosal vaccine for the elderly. (日)
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| ○キーワード (推奨): | 1. | (英) Adjuvants, Immunologic (日) (読)
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| 2. | (英) Administration, Intranasal (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | 細胞質分裂 (cytokinesis)
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| 5. | (英) DNA, Complementary (日) (読)
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| 6. | (英) Dendritic Cells (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Immunoglobulin A (日) (読)
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| 9. | (英) Membrane Proteins (日) (読)
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| 10. | (英) Mice (日) (読)
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| 11. | (英) Mice, Inbred BALB C (日) (読)
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| 12. | (英) Nasal Mucosa (日) (読)
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| 13. | (英) Nasopharynx (日) (読)
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| 14. | (英) Oligodeoxyribonucleotides (日) (読)
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| 15. | (英) Ovalbumin (日) (読)
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| 16. | (英) Plasmids (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Vaccine (The Edward Jenner Society/The International Society for Vaccines/日本ワクチン学会)
(pISSN: 0264-410X, eISSN: 1873-2518)
| ○ISSN (任意): | □ | 0264-410X
ISSN: 0264-410X
(pISSN: 0264-410X, eISSN: 1873-2518) Title: VaccineTitle(ISO): VaccinePublisher: Elsevier Ltd (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 26
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| ○号 (必須): | □ | 37
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| ○頁 (必須): | □ | 4849 4859
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 7月 14日 (平成 20年 7月 14日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.vaccine.2008.06.091 (→Scopusで検索)
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| ○PMID (任意): | □ | 18625280 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: The Immunobiology Vaccine Center, Department of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham, AL 35294-0007, USA. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 5. | (英) OtherID: NIHMS68975 (日)
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| 6. | (英) OtherID: PMC2601556 (日)
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