『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=214827)

EID=214827EID:214827, Map:0, LastModified:2012年9月16日(日) 21:37:27, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[木戸 博], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域]) [継承]
著者 (必須): 1.Wang Siye
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Trong Quang Le (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Naoki Kurihara (日) 栗原 直樹 (読) くりはら なおき
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学籍番号 (推奨):
[継承]
4.千田 淳司 ([徳島大学.先端酵素学研究所.基幹研究部門])
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学籍番号 (推奨):
[継承]
5.Cisse Youssouf ([徳島大学.疾患酵素学研究センター])
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学籍番号 (推奨):
[継承]
6.矢野 仁康
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学籍番号 (推奨):
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7.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Influenza Virus Cytokine Protease Cycle in the Pathogenesis of Vascular Hyperpermeability in Severe Influenza  (日)    [継承]
副題 (任意):
要約 (任意): (英) Severe influenza is characterized by cytokine storm and multiorgan failure with edema. The aim of this study was to define the impact of the cytokine storm on the pathogenesis of vascular hyperpermeability in severe influenza. Weanling mice were infected with influenza A WSN/33(H1N1) virus. The levels of proinflammatory cytokines, tumor necrosis factor (TNF) alpha, interleukin (IL) 6, IL-1beta, and trypsin were analyzed in the lung, brain, heart, and cultured human umbilical vein endothelial cells. The effects of transcriptional inhibitors on cytokine and trypsin expressions and viral replication were determined. Influenza A virus infection resulted in significant increases in TNF-alpha, IL-6, IL-1beta, viral hemagglutinin-processing protease trypsin levels, and viral replication with vascular hyperpermeability in lung and brain in the first 6 days of infection. Trypsin upregulation was suppressed by transcriptional inhibition of cytokines in vivo and by anti-cytokine antibodies in endothelial cells. Calcium mobilization and loss of tight junction constituent, zonula occludens-1, associated with cytokine- and trypsin-induced endothelial hyperpermeability were inhibited by a protease-activated receptor-2 antagonist and a trypsin inhibitor. The influenza virus-cytokine-protease cycle is one of the key mechanisms of vascular hyperpermeability in severe influenza.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Brain Chemistry (日) (読) [継承]
3. (英) Capillary Permeability (日) (読) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5. (英) Cytokines (日) (読) [継承]
6. (英) Endothelial Cells (日) (読) [継承]
7. (英) Female (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Influenza A Virus, H1N1 Subtype (日) (読) [継承]
10. (英) Lung (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Mice, Inbred C57BL (日) (読) [継承]
13. (英) Myocardium (日) (読) [継承]
14. (英) Orthomyxoviridae Infections (日) (読) [継承]
15. (英) Peptide Hydrolases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Infectious Diseases (John McCormick Institute for Infectious Diseases/John Rockefeller McCormick Memorial Fund/Memorial Institute for Infectious Diseases/Infectious Diseases Society of America)
(pISSN: 0022-1899, eISSN: 1537-6613)

ISSN (任意): 1537-6613
ISSN: 0022-1899 (pISSN: 0022-1899, eISSN: 1537-6613)
Title: The Journal of infectious diseases
Title(ISO): J Infect Dis
Publisher: Oxford University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 202 [継承]
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(必須): 991 1001 [継承]
都市 (任意): (英) America (日) (読) [継承]
年月日 (必須): 西暦 2010年 10月 1日 (平成 22年 10月 1日) [継承]
URL (任意):
DOI (任意): 10.1086/656044    (→Scopusで検索) [継承]
PMID (任意): 20731583    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Siye Wang, Le Quang Trong, Kurihara Naoki, Junji Chida, Youssouf Cisse, Mihiro Yano and Hiroshi Kido : Influenza Virus Cytokine Protease Cycle in the Pathogenesis of Vascular Hyperpermeability in Severe Influenza, The Journal of Infectious Diseases, Vol.202, No.7, 991-1001, 2010.
欧文冊子 ● Siye Wang, Le Quang Trong, Kurihara Naoki, Junji Chida, Youssouf Cisse, Mihiro Yano and Hiroshi Kido : Influenza Virus Cytokine Protease Cycle in the Pathogenesis of Vascular Hyperpermeability in Severe Influenza, The Journal of Infectious Diseases, Vol.202, No.7, 991-1001, 2010.

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