『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.疾患プロテオゲノム研究センター (2008年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.プロテオゲノム研究領域]) [継承]
著者 (必須): 1. (英) White J. Andrea (日) (読)
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[継承]
2. (英) Nakamura Kyoko (日) (読)
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[継承]
3. (英) Jenkinson E. William (日) (読)
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[継承]
4. (英) Saini Manoj (日) (読)
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[継承]
5. (英) Sinclair Charles (日) (読)
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[継承]
6. (英) Seddon Benedict (日) (読)
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[継承]
7. (英) Narendran Parth (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Pfeffer Klaus (日) (読)
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学籍番号 (推奨):
[継承]
9.新田 剛
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[継承]
10.高浜 洋介
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学籍番号 (推奨):
[継承]
11. (英) Caamano H. Jorge (日) (読)
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学籍番号 (推奨):
[継承]
12. (英) Lane J. L. Peter (日) (読)
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学籍番号 (推奨):
[継承]
13. (英) Jenkinson J. Eric (日) (読)
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[継承]
14. (英) Anderson Graham (日) (読)
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[継承]
題名 (必須): (英) Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) The thymic medulla represents a key site for the induction of T cell tolerance. In particular, autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) provide a spectrum of tissue-restricted Ags that, through both direct presentation and cross-presentation by dendritic cells, purge the developing T cell repertoire of autoimmune specificities. Despite this role, the mechanisms of Aire(+) mTEC development remain unclear, particularly those stages that occur post-Aire expression and represent mTEC terminal differentiation. In this study, in mouse thymus, we analyze late-stage mTEC development in relation to the timing and requirements for Aire and involucrin expression, the latter a marker of terminally differentiated epithelium including Hassall's corpuscles. We show that Aire expression and terminal differentiation within the mTEC lineage are temporally separable events that are controlled by distinct mechanisms. We find that whereas mature thymocytes are not essential for Aire(+) mTEC development, use of an inducible ZAP70 transgenic mouse line--in which positive selection can be temporally controlled--demonstrates that the emergence of involucrin(+) mTECs critically depends upon the presence of mature single positive thymocytes. Finally, although initial formation of Aire(+) mTECs depends upon RANK signaling, continued mTEC development to the involucrin(+) stage maps to activation of the LTα-LTβR axis by mature thymocytes. Collectively, our results reveal further complexity in the mechanisms regulating thymus medulla development and highlight the role of distinct TNFRs in initial and terminal differentiation stages in mTECs.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Differentiation (日) (読) [継承]
3. (英) Cell Separation (日) (読) [継承]
4. (英) Epithelial Cells (日) (読) [継承]
5. (英) Flow Cytometry (日) (読) [継承]
6. (英) Fluorescent Antibody Technique (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Lymphotoxin-alpha (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Inbred C57BL (日) (読) [継承]
11. (英) Mice, Transgenic (日) (読) [継承]
12. (英) Microscopy, Confocal (日) (読) [継承]
13. (英) Protein Precursors (日) (読) [継承]
14. (英) Receptors, Tumor Necrosis Factor (日) (読) [継承]
15. (英) Self Tolerance (日) (読) [継承]
16.シグナル伝達 (signal transduction) [継承]
17.Tリンパ球 (T lymphocytes) [継承]
18. (英) Thymus Gland (日) (読) [継承]
19. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 185 [継承]
(必須): 8 [継承]
(必須): 4769 4776 [継承]
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年月日 (必須): 西暦 2010年 9月 22日 (平成 22年 9月 22日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.1002151    (→Scopusで検索) [継承]
PMID (任意): 20861360    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Andrea J. White, Kyoko Nakamura, William E. Jenkinson, Manoj Saini, Charles Sinclair, Benedict Seddon, Parth Narendran, Klaus Pfeffer, Takeshi Nitta, Yousuke Takahama, Jorge H. Caamano, Peter J. L. Lane, Eric J. Jenkinson and Graham Anderson : Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells, The Journal of Immunology, Vol.185, No.8, 4769-4776, 2010.
欧文冊子 ● Andrea J. White, Kyoko Nakamura, William E. Jenkinson, Manoj Saini, Charles Sinclair, Benedict Seddon, Parth Narendran, Klaus Pfeffer, Takeshi Nitta, Yousuke Takahama, Jorge H. Caamano, Peter J. L. Lane, Eric J. Jenkinson and Graham Anderson : Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells, The Journal of Immunology, Vol.185, No.8, 4769-4776, 2010.

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