『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=213966EID:213966, Map:0, LastModified:2013年8月23日(金) 15:54:48, Operator:[永廣 信治], Avail:TRUE, Censor:0, Owner:[永廣 信治], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨): 博士後期課程学生による研究報告 [継承]
組織 (推奨):
著者 (必須): 1.八木 謙次
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[継承]
2. (英) Kitazato T. Keiko (日) 北里 慶子 (読) きたざと けいこ
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[継承]
3.宇野 昌明
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[継承]
4.多田 恵曜 ([徳島大学.病院.中央診療施設等.てんかんセンター])
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[継承]
5.木内 智也
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[継承]
6.島田 健司 ([徳島大学.病院.中央診療施設等.地域脳神経外科診療部])
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[継承]
7.永廣 信治
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題名 (必須): (英) Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasmininogen activator  (日)    [継承]
副題 (任意):
要約 (任意): (英) Intracerebral hemorrhage, induced by recombinant tissue plasminogen activator (rtPA) in ischemic stroke, is attributable to the increased activity of matrix metalloproteinase-9 (MMP-9). Patients with acute infarct benefit from the neuroprotective drug edaravone, a free radical scavenger. We examined the mechanisms by which edaravone may help to suppress rtPA-induced brain hemorrhage. Male Wistar rats weighing 250 to 280 g were subjected to 3-hour transient middle cerebral artery occlusion (MCAO) and divided randomly into 3 groups. Immediately after reperfusion, 1 group was intravenously injected with 10 mg/kg rtPA, another with rtPA plus 3 mg/kg edaravone, and the 3rd group received no treatment. We assessed the hemorrhage volume and the activity of MMP-9 in the brain 24 hours postischemia. We also studied the activity of MMP-9, its mRNA expression, and nuclear factor-kappa B (NF-kappaB) activity in rtPA-stimulated human microvascular endothelial cells (HBECs). The degree of hemorrhage and the level of endothelial cell-derived MMP-9 were elevated in rats treated with rtPA alone and attenuated in rats treated with rtPA plus edaravone. In rtPA-stimulated HBECs, edaravone suppressed the activity and mRNA expression of MMP-9 in a dose-dependent manner. Edaravone also inhibited NF-kappaB activation. We demonstrate that edaravone inhibits rtPA-induced cerebral hemorrhage in the ischemic brain of rats via the inhibition of MMP-9 expression in vivo, which is substantiated by inhibition of MMP-9 expression and NF-kappaB activation in HBECs. Edaravone may render thrombolytic therapy safer for the administration of rtPA in patients with ischemic stroke.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antipyrine (日) (読) [継承]
3.血圧 (blood pressure) [継承]
4. (英) Blotting, Western (日) (読) [継承]
5. (英) Brain Ischemia (日) (読) [継承]
6. (英) Cells, Cultured (日) (読) [継承]
7. (英) Cerebral Hemorrhage (日) (読) [継承]
8. (英) Dose-Response Relationship, Drug (日) (読) [継承]
9. (英) Endothelial Cells (日) (読) [継承]
10. (英) Free Radical Scavengers (日) (読) [継承]
11.免疫組織化学 (immunohistochemistry) [継承]
12. (英) Infarction, Middle Cerebral Artery (日) (読) [継承]
13. (英) Male (日) (読) [継承]
14. (英) Matrix Metalloproteinase 9 (日) (読) [継承]
15. (英) Middle Cerebral Artery (日) (読) [継承]
16. (英) NF-kappa B (日) (読) [継承]
17. (英) RNA, Messenger (日) (読) [継承]
18. (英) Rats (日) (読) [継承]
19. (英) Rats, Wistar (日) (読) [継承]
20. (英) Reperfusion Injury (日) (読) [継承]
21. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
22. (英) Tissue Plasminogen Activator (日) (読) [継承]
発行所 (推奨): American Heart Association [継承]
誌名 (必須): Stroke ([American Heart Association])
(pISSN: 0039-2499, eISSN: 1524-4628)

ISSN (任意): 1524-4628
ISSN: 0039-2499 (pISSN: 0039-2499, eISSN: 1524-4628)
Title: Stroke
Title(ISO): Stroke
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 40 [継承]
(必須): 2 [継承]
(必須): 626 631 [継承]
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年月日 (必須): 西暦 2009年 4月 初日 (平成 21年 4月 初日) [継承]
URL (任意):
DOI (任意): 10.1161/STROKEAHA.108.520262    (→Scopusで検索) [継承]
PMID (任意): 19095969    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. kenji-yagi@mail.goo.ne.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kenji Yagi, Keiko T. Kitazato, Masaaki Uno, Yoshiteru Tada, Tomoya Kinouchi, Kenji Shimada and Shinji Nagahiro : Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasmininogen activator, Stroke, Vol.40, No.2, 626-631, 2009.
欧文冊子 ● Kenji Yagi, Keiko T. Kitazato, Masaaki Uno, Yoshiteru Tada, Tomoya Kinouchi, Kenji Shimada and Shinji Nagahiro : Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasmininogen activator, Stroke, Vol.40, No.2, 626-631, 2009.

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