| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○著者 (必須): | 1. | 細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 2. | (英) Hosokawa Ikuko (日) (読)
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| 3. | 尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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| 4. | 中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 5. | 中江 英明
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| 6. | 松尾 敬志
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| ○題名 (必須): | □ | (英) Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts. (日)
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| ○要約 (任意): | □ | (英) IL-6 is well recognized to be a potent bone resorptive agent and thus in the development of periodontal disease. Epigallocatechin gallate (EGCG) and epicatechin gallate (ECG), the major catechins in green tea, and theaflavin-3,3'-digallate (TFDG), polyphenol in black tea, have multiple beneficial effects, but the effects of catechins and theaflavins on IL-6 production in human gingival fibroblasts (HGFs) are not known. In this study, we investigated the mechanisms by which EGCG, ECG, and TFDG inhibit tumor necrosis factor superfamily 14 (TNFSF14)-induced IL-6 production in HGFs. We detected TNFSF14 mRNA expression in human diseased periodontal tissues. TNFSF14 increased IL-6 production in HGFs in a concentration-dependent manner. EGCG, ECG, and TFDG prevented TNFSF14-mediated IL-6 production in HGFs. EGCG, ECG, and TFDG prevented TNFSF14-induced extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and nuclear factor-kappaB activation in HGFs. Inhibitors of ERK, JNK, and nuclear factor-kappaB decreased TNFSF14-induced IL-6 production. In addition, EGCG, ECG, and TFDG attenuated TNFSF14 receptor expression on HGFs. These data provide a novel mechanism through which the green tea and black tea polyphenols could be used to provide direct benefits in periodontal disease. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Molecular Nutrition & Food Research ([Wiley-VCH])
(pISSN: 1613-4125, eISSN: 1613-4133)
| ○ISSN (任意): | □ | 1613-4133
ISSN: 1613-4125
(pISSN: 1613-4125, eISSN: 1613-4133) Title: Molecular nutrition & food researchTitle(ISO): Mol Nutr Food ResPublisher: Wiley (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 54 Suppl 2
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | S151 8
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2010年 7月 初日 (平成 22年 7月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/mnfr.200900549 (→Scopusで検索)
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| ○PMID (任意): | □ | 20461739 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Affiliation: Department of Conservative Dentistry, The University of Tokushima Graduate School, Tokushima, Japan. hosokawa@dent.tokushima-u.ac.jp (日)
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| 2. | (英) PublicationType: Journal Article (日)
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| 3. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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