| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Mikura Mayumi (日) (読)
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| 2. | (英) Yamaoka Ippei (日) (読)
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| 3. | (英) Doi Masako (日) (読)
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| 4. | (英) Kawano Yuichi (日) (読)
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| 5. | (英) Nakayama Mitsuo (日) (読)
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| 6. | (英) Nakao Reiko (日) (読)
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| 7. | 平坂 勝也
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| 8. | 奥村 裕司
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| 9. | 二川 健 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学])
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| ○題名 (必須): | □ | (英) Glucose Infusion Suppresses Surgery-induced Muscle Protein Breakdown by Inhibiting Ubiquitin-proteasome Pathway in Rats (日)
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| ○要約 (任意): | □ | (英) It appears to have been well established that after surgery, protein catabolism is accelerated and glucose infusion suppresses the catabolic reactions. However, in the early postoperative period, the effects of surgical stress and glucose infusion on muscle protein catabolism and the related mechanisms remain unclear. Rats undergoing laparotomy were infused with acetated Ringer's solution (10 ml x kg(-1) x h(-1)) without glucose (control) or containing 1% or 5% glucose. The infusion was continued for a further 4 h after the surgical treatment. The catabolic index, excretion of urinary nitrogen and 3-methylhistidine, and release of tyrosine and 3-methylhistidine from isolated muscle were determined. Furthermore, muscular mRNA expression of proteolytic-related genes (atrogin-1/MAFbx, muscle ring finger-1, mu- and m-calpain, and cathepsin L and H) and phosphorylation of components of insulin signaling (forkhead box O3 and protein kinase B) were evaluated. Surgery increased the catabolic index, and this increase was suppressed by glucose infusion (both 1% and 5%). In the control group, mRNA expression of atrogin-1/MAFbx and muscle ring finger-1 was increased, and they were suppressed in the two glucose groups. Furthermore, insulin signaling (phosphorylation of protein kinase B and forkhead box O3) in muscles was stimulated by glucose infusion. The present study indicates that glucose infusion, even at a relatively low rate, suppresses muscle protein breakdown in the early postoperative period. The mechanism of this effect is related to the suppression of the ubiquitin-proteasome pathway, accompanied by activation of insulin signaling. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | グルコース (glucose)
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| 3. | (英) Infusions, Intravenous (日) (読)
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| 4. | (英) Male (日) (読)
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| 5. | 代謝 (metabolism)
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| 6. | (英) Muscle Proteins (日) (読)
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| 7. | (英) Muscle, Skeletal (日) (読)
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| 8. | (英) Postoperative Complications (日) (読)
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| 9. | (英) Proteasome Endopeptidase Complex (日) (読)
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| 10. | (英) Rats (日) (読)
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| 11. | (英) Rats, Sprague-Dawley (日) (読)
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| 12. | シグナル伝達 (signal transduction)
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| 13. | (英) Ubiquitin (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Anesthesiology ([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)
| ○ISSN (任意): | □ | 1528-1175
ISSN: 0003-3022
(pISSN: 0003-3022, eISSN: 1528-1175) Title: AnesthesiologyTitle(ISO): AnesthesiologyPublisher: Lippincott Williams and Wilkins Ltd. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 110
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 81 88
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2009年 1月 初日 (平成 21年 1月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1097/ALN.0b013e318190b6c1 (→Scopusで検索)
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| ○PMID (任意): | □ | 19104174 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000262052600016
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| ○Scopus (任意): | □ | 2-s2.0-58749093268
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| ○備考 (任意): | 1. | (英) Article.Affiliation: New Product and Business Development, Research and Development Center, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan. mikuramu@otsukakj.co.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Comparative Study (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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