『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=213355EID:213355, Map:0, LastModified:2013年10月1日(火) 11:47:24, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[細井 和雄], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座.口腔分子生理学 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1.姚 陳娟 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
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[継承]
2. (英) Purwanti, Nunuk (日) (読)
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[継承]
3. (英) Karabasil, Ratko, Mileva (日) (読)
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[継承]
4. (英) Azlina, Ahmad (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Purevjav, Javkhlan (日) (読)
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学籍番号 (推奨):
[継承]
6.長谷川 敬展 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
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[継承]
7.赤松 徹也 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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[継承]
8. (英) Hosoi, Toru (日) 細井 徹 (読) ほそい とおる
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9. (英) Ozawa Koichiro (日) 小澤 孝一郎 (読) おざわ こういちろう
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[継承]
10.細井 和雄
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[継承]
題名 (必須): (英) Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-κB and p-c-Jun/c-Fos  (日)    [継承]
副題 (任意):
要約 (任意): (英) The mRNA and protein levels of aquaporin (AQP)5 in the parotid gland were found to be potentially decreased by lipopolysaccharide (LPS) in vivo in C3H/HeN mice, but only weakly in C3H/HeJ, a TLR4 mutant mouse strain. In the LPS-injected mice, pilocarpine-stimulated saliva production was reduced by more than 50%. In a tissue culture system, the LPS-induced decrease in the AQP5 mRNA level was blocked completely by pyrrolidine dithiocarbamate, MG132, tyrphostin AG126, SP600125, and partially by SB203580, which are inhibitors for IkappaB kinase, 26S proteasome, ERK1/2, JNK, and p38 MAPK, respectively. In contrast, the expression of AQP1 mRNA was down-regulated by LPS and such down-regulation was blocked only by SP600125. The transcription factors NF-kappaB (p65 subunit), p-c-Jun, and c-Fos were increased by LPS given in vivo, whereas the protein-binding activities of the parotid gland extract toward the sequences for NF-kappaB but not AP-1-responsive elements present at the promoter region of the AQP5 gene were increased by LPS injection. Co-immunoprecipitation by using antibody columns suggested the physical association of the three transcription factors. These results suggest that LPS-induced potential down-regulation of expression of AQP5 mRNA in the parotid gland is mediated via a complex(es) of these two classes of transcription factors, NF-kappaB and p-c-Jun/c-Fos.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Aquaporin 1 (日) (読) [継承]
3. (英) Aquaporin 5 (日) (読) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5. (英) Enzyme Inhibitors (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) JNK Mitogen-Activated Protein Kinases (日) (読) [継承]
8. (英) Lipopolysaccharides (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Mice, Inbred C3H (日) (読) [継承]
12. (英) Mice, Inbred C57BL (日) (読) [継承]
13. (英) NF-kappa B (日) (読) [継承]
14. (英) Nitrates (日) (読) [継承]
15. (英) Nitrites (日) (読) [継承]
16. (英) Proto-Oncogene Proteins c-fos (日) (読) [継承]
17. (英) Salivary Glands (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The American Journal of Pathology ([American Society for Investigative Pathology])
(pISSN: 0002-9440, eISSN: 1525-2191)

ISSN (任意): 1525-2191
ISSN: 0002-9440 (pISSN: 0002-9440, eISSN: 1525-2191)
Title: The American journal of pathology
Title(ISO): Am J Pathol
Publisher: American Society for Investigative Pathology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 724 734 [継承]
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年月日 (必須): 西暦 2010年 8月 初日 (平成 22年 8月 初日) [継承]
URL (任意):
DOI (任意): 10.2353/ajpath.2010.090282    (→Scopusで検索) [継承]
PMID (任意): 20522648    (→Scopusで検索) [継承]
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WOS (任意): 000280894600023 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC2913374  (日)    [継承]

標準的な表示

和文冊子 ● Chenjuan Yao, Nunuk Purwanti, Mileva Ratko Karabasil, Ahmad Azlina, Javkhlan Purevjav, Takahiro Hasegawa, Tetsuya Akamatsu, Toru Hosoi, Koichiro Ozawa and Kazuo Hosoi : Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-κB and p-c-Jun/c-Fos, The American Journal of Pathology, Vol.177, No.2, 724-734, 2010.
欧文冊子 ● Chenjuan Yao, Nunuk Purwanti, Mileva Ratko Karabasil, Ahmad Azlina, Javkhlan Purevjav, Takahiro Hasegawa, Tetsuya Akamatsu, Toru Hosoi, Koichiro Ozawa and Kazuo Hosoi : Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-κB and p-c-Jun/c-Fos, The American Journal of Pathology, Vol.177, No.2, 724-734, 2010.

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