『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.医学部 [継承]
著者 (必須): 1.銭 志栄
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[継承]
2. (英) Li Chiun Chei (日) (読)
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[継承]
3. (英) Yamasaki Hiroyuki (日) (読)
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[継承]
4.水澤 典子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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[継承]
5.吉本 勝彦
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[継承]
6. (英) Yamada Shozo (日) (読)
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[継承]
7. (英) Tashiro Takashi (日) (読)
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[継承]
8.堀口 英久
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[継承]
9.若槻 真吾 ([徳島大学.医学部.医学科.器官病態修復医学講座.分子病理学分野])
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[継承]
10.廣川 満良
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[継承]
11.佐野 壽昭
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[継承]
題名 (必須): (英) Role of E-cadherin, alpha-, beta-, and gamma-catenins, and p120 (cell adhesion molecules) in prolactinoma behavior.  (日)    [継承]
副題 (任意):
要約 (任意): (英) E-cadherin/catenin complex regulates cellular adhesion and motility and is believed to function as an invasion suppressor system. In a number of cancers, abnormal and reduced expression of E-cadherin/catenin complex is associated with tumor invasion and metastasis. Prolactinomas show frequent invasion on the surrounding structures, despite their histologically benign nature. Furthermore, gender-based differences in endocrine and surgical findings are found in patients with prolactinoma. To understand biological factors governing prolactinoma behavior, this study analyzed the expression of E-cadherin; alpha-, beta-, and gamma-catenins; p120; and cell proliferation marker MIB-1 labeling index in 13 invasive tumors (9 in men, 4 in women), 26 noninvasive tumors (4 in men, 22 in women), and 8 normal anterior pituitaries by immunohistochemistry. Immunostaining of E-cadherin; alpha-, beta-, and gamma-catenins; and p120 showed a membranous pattern of reactivity and generally stronger in normal pituitaries than in prolactinomas. Expression of E-cadherin and beta-catenin was significantly lower in invasive than in noninvasive prolactinomas (P <.002 and P <.005, respectively), and reduced expression of E-cadherin and beta-catenin was more frequent in invasive than in noninvasive prolactinomas (P <.001 and P <.05, respectively); in contrast, gamma-catenin expression showed higher in invasive than in noninvasive prolactinomas (P <.05). Expression of E-cadherin was significantly lower in macroprolactinomas than in microprolactinomas (P <.01), and decreased expression of E-cadherin and beta-catenin predicted high MIB-1 expression (P <.05). Moreover, the expression of E-cadherin and beta-catenin was significantly lower in macroprolactinomas in men than in those in women (P <.01 and P <.02, respectively). No statistical correlations were observed between expression of alpha-catenin, p120, and clinicopathologic features. In conclusion, the reduction of E-cadherin and beta-catenin expression was related to invasiveness and proliferative status of prolactinomas and correlated with the more aggressive behavior of prolactinomas in men compared with in women.  (日)    [継承]
キーワード (推奨): 1. (英) Adolescent (日) (読) [継承]
2. (英) Adult (日) (読) [継承]
3. (英) Aged (日) (読) [継承]
4. (英) Cadherins (日) (読) [継承]
5. (英) Cell Adhesion Molecules (日) (読) [継承]
6. (英) Cytoskeletal Proteins (日) (読) [継承]
7. (英) Desmoplakins (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10.免疫組織化学 (immunohistochemistry) [継承]
11. (英) Ki-67 Antigen (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Middle Aged (日) (読) [継承]
14. (英) Phosphoproteins (日) (読) [継承]
15. (英) Pituitary Neoplasms (日) (読) [継承]
16. (英) Prolactinoma (日) (読) [継承]
17. (英) Trans-Activators (日) (読) [継承]
18. (英) alpha Catenin (日) (読) [継承]
19. (英) beta Catenin (日) (読) [継承]
20. (英) gamma Catenin (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Modern Pathology (United States and Canadian Academy of Pathology)
(pISSN: 0893-3952, eISSN: 1530-0285)

ISSN (任意): 0893-3952
ISSN: 0893-3952 (pISSN: 0893-3952, eISSN: 1530-0285)
Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Title(ISO): Mod Pathol
Publisher: Springer Science+Business Media
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(必須): 15 [継承]
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(必須): 1357 1365 [継承]
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年月日 (必須): 西暦 2002年 12月 10日 (平成 14年 12月 10日) [継承]
URL (任意):
DOI (任意): 10.1097/01.MP.0000039572.75188.1A    (→Scopusで検索) [継承]
PMID (任意): 12481018    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Pathology, School of Medicine, Tokushima University, Tokushima, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Zhi-Rong Qian, Chei Chiun Li, Hiroyuki Yamasaki, Noriko Mizusawa, Katsuhiko Yoshimoto, Shozo Yamada, Takashi Tashiro, Hidehisa Horiguchi, Shingo Wakatsuki, Mitsuyoshi Hirokawa and Toshiaki Sano : Role of E-cadherin, alpha-, beta-, and gamma-catenins, and p120 (cell adhesion molecules) in prolactinoma behavior., Modern Pathology, Vol.15, No.12, 1357-1365, 2002.
欧文冊子 ● Zhi-Rong Qian, Chei Chiun Li, Hiroyuki Yamasaki, Noriko Mizusawa, Katsuhiko Yoshimoto, Shozo Yamada, Takashi Tashiro, Hidehisa Horiguchi, Shingo Wakatsuki, Mitsuyoshi Hirokawa and Toshiaki Sano : Role of E-cadherin, alpha-, beta-, and gamma-catenins, and p120 (cell adhesion molecules) in prolactinoma behavior., Modern Pathology, Vol.15, No.12, 1357-1365, 2002.

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