| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部
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| ○著者 (必須): | 1. | 銭 志栄
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| ○学籍番号 (推奨): |
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| 2. | (英) Li Chiun Chei (日) (読)
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| 3. | (英) Yamasaki Hiroyuki (日) (読)
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| 4. | 水澤 典子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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| 5. | 吉本 勝彦
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| 6. | (英) Yamada Shozo (日) (読)
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| 7. | (英) Tashiro Takashi (日) (読)
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| 8. | 堀口 英久
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| 9. | 若槻 真吾 ([徳島大学.医学部.医学科.器官病態修復医学講座.分子病理学分野])
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| 10. | 廣川 満良
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| 11. | 佐野 壽昭
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| ○題名 (必須): | □ | (英) Role of E-cadherin, alpha-, beta-, and gamma-catenins, and p120 (cell adhesion molecules) in prolactinoma behavior. (日)
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| ○要約 (任意): | □ | (英) E-cadherin/catenin complex regulates cellular adhesion and motility and is believed to function as an invasion suppressor system. In a number of cancers, abnormal and reduced expression of E-cadherin/catenin complex is associated with tumor invasion and metastasis. Prolactinomas show frequent invasion on the surrounding structures, despite their histologically benign nature. Furthermore, gender-based differences in endocrine and surgical findings are found in patients with prolactinoma. To understand biological factors governing prolactinoma behavior, this study analyzed the expression of E-cadherin; alpha-, beta-, and gamma-catenins; p120; and cell proliferation marker MIB-1 labeling index in 13 invasive tumors (9 in men, 4 in women), 26 noninvasive tumors (4 in men, 22 in women), and 8 normal anterior pituitaries by immunohistochemistry. Immunostaining of E-cadherin; alpha-, beta-, and gamma-catenins; and p120 showed a membranous pattern of reactivity and generally stronger in normal pituitaries than in prolactinomas. Expression of E-cadherin and beta-catenin was significantly lower in invasive than in noninvasive prolactinomas (P <.002 and P <.005, respectively), and reduced expression of E-cadherin and beta-catenin was more frequent in invasive than in noninvasive prolactinomas (P <.001 and P <.05, respectively); in contrast, gamma-catenin expression showed higher in invasive than in noninvasive prolactinomas (P <.05). Expression of E-cadherin was significantly lower in macroprolactinomas than in microprolactinomas (P <.01), and decreased expression of E-cadherin and beta-catenin predicted high MIB-1 expression (P <.05). Moreover, the expression of E-cadherin and beta-catenin was significantly lower in macroprolactinomas in men than in those in women (P <.01 and P <.02, respectively). No statistical correlations were observed between expression of alpha-catenin, p120, and clinicopathologic features. In conclusion, the reduction of E-cadherin and beta-catenin expression was related to invasiveness and proliferative status of prolactinomas and correlated with the more aggressive behavior of prolactinomas in men compared with in women. (日)
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| ○キーワード (推奨): | 1. | (英) Adolescent (日) (読)
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| 2. | (英) Adult (日) (読)
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| 3. | (英) Aged (日) (読)
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| 4. | (英) Cadherins (日) (読)
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| 5. | (英) Cell Adhesion Molecules (日) (読)
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| 6. | (英) Cytoskeletal Proteins (日) (読)
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| 7. | (英) Desmoplakins (日) (読)
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| 8. | (英) Female (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | 免疫組織化学 (immunohistochemistry)
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| 11. | (英) Ki-67 Antigen (日) (読)
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| 12. | (英) Male (日) (読)
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| 13. | (英) Middle Aged (日) (読)
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| 14. | (英) Phosphoproteins (日) (読)
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| 15. | (英) Pituitary Neoplasms (日) (読)
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| 16. | (英) Prolactinoma (日) (読)
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| 17. | (英) Trans-Activators (日) (読)
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| 18. | (英) alpha Catenin (日) (読)
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| 19. | (英) beta Catenin (日) (読)
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| 20. | (英) gamma Catenin (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Modern Pathology (United States and Canadian Academy of Pathology)
(pISSN: 0893-3952, eISSN: 1530-0285)
| ○ISSN (任意): | □ | 0893-3952
ISSN: 0893-3952
(pISSN: 0893-3952, eISSN: 1530-0285) Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncTitle(ISO): Mod PatholPublisher: Springer Nature (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 15
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| ○号 (必須): | □ | 12
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| ○頁 (必須): | □ | 1357 1365
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2002年 12月 10日 (平成 14年 12月 10日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1097/01.MP.0000039572.75188.1A (→Scopusで検索)
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| ○PMID (任意): | □ | 12481018 (→Scopusで検索)
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Affiliation: Department of Pathology, School of Medicine, Tokushima University, Tokushima, Japan. (日)
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| 2. | (英) PublicationType: Journal Article (日)
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