『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.佐野 壽昭
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[継承]
2. (英) Mader Rene (日) (読)
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[継承]
3. (英) Asa Sylvia L (日) (読)
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[継承]
4.銭 志栄
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[継承]
5. (英) Hino Akiko (日) (読)
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[継承]
6. (英) Yamada Shozo (日) (読)
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題名 (必須): (英) "Honeycomb Golgi" in pituitary adenomas: not a marker of gonadotroph adenomas.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The vacuolar change in Golgi complexes known as "honeycomb Golgi" has been described as the ultrastructural hallmark of a specific tumor that has been called the "female gonadotroph" adenoma of the human pituitary. Recently, a few adenomas presenting with Cushing's disease have been reported to exhibit this feature. To clarify the significance of a "honeycomb Golgi" in the classification of pituitary adenomas, we studied clinically nonfunctioning adenomas with or without "honeycomb Golgi" using immunohistochemistry for adenohypophysial hormones and RT-PCR for the cell-specific transcription factors Tpit that identifies corticotrophs and SF-1 that identifies gonadotrophs. All adenomas were from women. Among 20 adenomas with complete "honeycomb Golgi" change, gonadotrophin subunits were totally immunonegative, but ACTH was positive in a few cells of 12 adenomas. Among eight adenomas with partial vacuolar change of the Golgi complex, five were positive for gonadotrophins and two were positive for ACTH. A subgroup of these lesions were examined by RT-PCR and among eight adenomas with typical "honeycomb Golgi" one case expressed both Tpit and SF-1, probably due to contamination with normal pituitary and another expressed neither Tpit nor SF-1. Of the remaining six cases, Tpit was expressed in two cases and SF-1 in four. These findings indicate that "honeycomb Golgi" change can been seen in corticotroph adenomas as well as gonadotroph adenomas. The reason why this vacuolar change occurs only in females remains to be clarified.  (日)    [継承]
キーワード (推奨): 1. (英) Adenoma (日) (読) [継承]
2. (英) Adrenocorticotropic Hormone (日) (読) [継承]
3. (英) Adult (日) (読) [継承]
4. (英) Aged (日) (読) [継承]
5. (英) DNA-Binding Proteins (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Fushi Tarazu Transcription Factors (日) (読) [継承]
8. (英) Golgi Apparatus (日) (読) [継承]
9. (英) Gonadotropins, Pituitary (日) (読) [継承]
10. (英) Homeodomain Proteins (日) (読) [継承]
11. (英) Humans (日) (読) [継承]
12.免疫組織化学 (immunohistochemistry) [継承]
13. (英) Microscopy, Electron (日) (読) [継承]
14. (英) Middle Aged (日) (読) [継承]
15. (英) Pituitary Hormones, Anterior (日) (読) [継承]
16. (英) Pituitary Neoplasms (日) (読) [継承]
17. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
18. (英) T-Box Domain Proteins (日) (読) [継承]
19. (英) Transcription Factors (日) (読) [継承]
20. (英) Vacuoles (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrine Pathology (Endocrine Pathology Society)
(pISSN: 1046-3976, eISSN: 1559-0097)

ISSN (任意): 1046-3976
ISSN: 1046-3976 (pISSN: 1046-3976, eISSN: 1559-0097)
Title: Endocrine pathology
Title(ISO): Endocr Pathol
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 14 [継承]
(必須): 4 [継承]
(必須): 363 368 [継承]
都市 (任意):
年月日 (必須): 西暦 2003年 12月 10日 (平成 15年 12月 10日) [継承]
URL (任意):
DOI (任意): 10.1385/EP:14:4:363    (→Scopusで検索) [継承]
PMID (任意): 14739492    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000188887200007 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Pathology, University of Tokushima School of Medicine, Tokushima, Japan. sano@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Toshiaki Sano, Rene Mader, L Sylvia Asa, Zhi-Rong Qian, Akiko Hino and Shozo Yamada : "Honeycomb Golgi" in pituitary adenomas: not a marker of gonadotroph adenomas., Endocrine Pathology, Vol.14, No.4, 363-368, 2003.
欧文冊子 ● Toshiaki Sano, Rene Mader, L Sylvia Asa, Zhi-Rong Qian, Akiko Hino and Shozo Yamada : "Honeycomb Golgi" in pituitary adenomas: not a marker of gonadotroph adenomas., Endocrine Pathology, Vol.14, No.4, 363-368, 2003.

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