『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=212958)

EID=212958EID:212958, Map:0, LastModified:2012年8月28日(火) 22:20:36, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Obari Abdulkader (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.佐野 壽昭
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Ohyama Kenichi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.工藤 英治
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.銭 志栄
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Yoneda Akiko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Rayhan Nasim (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Mustafizur Rahman Muhammad (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Yamada Shozo (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Clinicopathological features of growth hormone-producing pituitary adenomas: difference among various types defined by cytokeratin distribution pattern including a transitional form.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Pituitary adenomas producing almost exclusively growth hormones (GH) have been ultrastructurally classified into two distinct types: densely granulated somatotroph (DG) adenomas and sparsely granulated (SG) adenomas. Fibrous body (FB), an intracytoplasmic globular aggregation of cytokeratin (CK) filaments, is a hallmark of SG adenomas. Under light microscope, FB could be identified by CK immunohistochemistry as a dot-pattern immunoreaction versus a perinuclear pattern for cells without FB. However, it has been noted that numerous adenomas contain mixed populations of the two patterns. To clarify clinicopathological characteristics of the adenomas with mixed populations ("intermediate type" adenomas) and to confirm clinicopathological differences between strictly defined DG-type and SG-type adenomas, we performed this study on 104 GH cell adenomas. Having segregated "intermediate-type" adenomas (26 cases), we found significant differences between typical DG-type (47 cases) and SG-type adenomas (31 cases); SG-type adenomas had younger ages (44 vs. 50), higher frequency of macroadenomas (86% vs. 58%), invasiveness (65% vs. 38%), advanced grades (3 or 4) in Knosp's classification (50% vs. 24%), and weaker immunoreaction for GH, beta-TSH, alpha-subunit, E-cadherin, and beta-catenin. Clinicopathological characteristics of "intermediate-type" adenomas were identical to those of DG-type adenomas. These findings confirm that SG-type adenoma is a distinct section of GH cell adenomas with special properties and biological behavior, and suggest that intermediate-phenotype adenomas are enrolled in DG-type adenomas. Special properties and biological behavior of SG-type adenomas may appear after the majority of tumor cells possess a fully developed fibrous body.  (日)    [継承]
キーワード (推奨): 1. (英) Acromegaly (日) (読) [継承]
2. (英) Adenoma (日) (読) [継承]
3. (英) Adolescent (日) (読) [継承]
4. (英) Adult (日) (読) [継承]
5. (英) Aged (日) (読) [継承]
6.加齢 (aging/->キーワード[老化]) [継承]
7. (英) Cadherins (日) (読) [継承]
8. (英) Cell Count (日) (読) [継承]
9. (英) Cytoplasm (日) (読) [継承]
10. (英) Female (日) (読) [継承]
11. (英) Growth Hormone-Secreting Pituitary Adenoma (日) (読) [継承]
12. (英) Human Growth Hormone (日) (読) [継承]
13. (英) Humans (日) (読) [継承]
14.免疫組織化学 (immunohistochemistry) [継承]
15. (英) Keratins (日) (読) [継承]
16. (英) Male (日) (読) [継承]
17. (英) Middle Aged (日) (読) [継承]
18. (英) Pituitary Neoplasms (日) (読) [継承]
19. (英) Thyrotropin (日) (読) [継承]
20. (英) Tissue Fixation (日) (読) [継承]
21. (英) beta Catenin (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrine Pathology (Endocrine Pathology Society)
(pISSN: 1046-3976, eISSN: 1559-0097)

ISSN (任意): 1046-3976
ISSN: 1046-3976 (pISSN: 1046-3976, eISSN: 1559-0097)
Title: Endocrine pathology
Title(ISO): Endocr Pathol
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 19 [継承]
(必須): 2 [継承]
(必須): 82 91 [継承]
都市 (任意):
年月日 (必須): 西暦 2008年 8月 10日 (平成 20年 8月 10日) [継承]
URL (任意):
DOI (任意): 10.1007/s12022-008-9029-z    (→Scopusで検索) [継承]
PMID (任意): 18629656    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Affiliation: Department of Human Pathology, Institute of Health Bioscience, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Abdulkader Obari, Toshiaki Sano, Kenichi Ohyama, Eiji Kudo, Zhi-Rong Qian, Akiko Yoneda, Nasim Rayhan, Muhammad Rahman Mustafizur and Shozo Yamada : Clinicopathological features of growth hormone-producing pituitary adenomas: difference among various types defined by cytokeratin distribution pattern including a transitional form., Endocrine Pathology, Vol.19, No.2, 82-91, 2008.
欧文冊子 ● Abdulkader Obari, Toshiaki Sano, Kenichi Ohyama, Eiji Kudo, Zhi-Rong Qian, Akiko Yoneda, Nasim Rayhan, Muhammad Rahman Mustafizur and Shozo Yamada : Clinicopathological features of growth hormone-producing pituitary adenomas: difference among various types defined by cytokeratin distribution pattern including a transitional form., Endocrine Pathology, Vol.19, No.2, 82-91, 2008.

関連情報

Number of session users = 0, LA = 1.04, Max(EID) = 382693, Max(EOID) = 1022068.