『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=212957)

EID=212957EID:212957, Map:0, LastModified:2017年3月3日(金) 16:55:56, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[科長]/[徳島大学.病院.診療科.内科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨): 博士後期課程学生による研究報告 [継承]
組織 (推奨):
著者 (必須): 1. (英) Rahman M M (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.銭 志栄
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Wang E L (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Sultana R (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.工藤 英治
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Nakasono M (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Hayashi T (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.柿内 聡司
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9.佐野 壽昭
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Frequent overexpression of HMGA1 and 2 in gastroenteropancreatic neuroendocrine tumours and its relationship to let-7 downregulation.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The molecular pathogenesis of gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) remains to be elucidated. High-mobility group A (HMGA) proteins play important roles in the regulation of transcription, differentiation, and neoplastic transformation. In this study, the expression of HMGA1 and HMGA2 was studied in 55 GEP NETs. Overexpression of HMGA1 and 2 was frequently detected in GEP NETs compared with normal tissues. Nuclear immunostaining of HMGA1 and 2 was observed in GEP NETs (38 of 55, 69%; 40 of 55, 73%, respectively). High-mobility group A2 expression increased from well-differentiated NET (WNET) to well-differentiated neuroendocrine carcinoma (WNEC) and poorly differentiated NEC (PNEC) (P<0.005) and showed the highest level in stage IV tumours (P<0.01). In WNECs, the expression of HMGA1 and 2 was significantly higher in metastatic tumours than those without metastasis (P<0.05). Gastroenteropancreatic NETs in foregut showed the highest level of HMGA1 and 2 expressions. MIB-1 labelling index (MIB-1 LI) correlated with HMGA1 and 2 overexpression (R=0.28, P<0.05; R=0.434, P<0.001; respectively) and progressively increased from WNETs to WNECs and PNECs (P<0.001). Let-7 expression was addressed in 6 normal organs, 30 tumour samples, and 24 tumour margin non-tumour tissues. Compared with normal tissues, let-7 downregulation was frequent in NETs (19 of 30, 63%). Higher expression of HMGA1 and 2 was frequently observed in tumours with let-7 significant reduction (53, 42%, respectively). The reverse correlation could be detected between HMGA1 and let-7 (P<0.05). Our findings suggested that HMGA1 and 2 overexpression and let-7 downregulation might relate to pathogenesis of GEP NETs.  (日)    [継承]
キーワード (推奨): 1. (英) Digestive System Neoplasms (日) (読) [継承]
2. (英) Down-Regulation (日) (読) [継承]
3. (英) HMGA Proteins (日) (読) [継承]
4. (英) Humans (日) (読) [継承]
5.免疫組織化学 (immunohistochemistry) [継承]
6. (英) MicroRNAs (日) (読) [継承]
7. (英) Neuroendocrine Tumors (日) (読) [継承]
8. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
発行所 (推奨):
誌名 (必須): British Journal of Cancer (British Empire Cancer Campaign/Cancer Research UK)
(pISSN: 0007-0920, eISSN: 1532-1827)

ISSN (任意): 1532-1827
ISSN: 0007-0920 (pISSN: 0007-0920, eISSN: 1532-1827)
Title: British journal of cancer
Title(ISO): Br J Cancer
Publisher: Springer Nature
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 100 [継承]
(必須): 3 [継承]
(必須): 501 510 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 1月 20日 (平成 21年 1月 20日) [継承]
URL (任意):
DOI (任意): 10.1038/sj.bjc.6604883    (→Scopusで検索) [継承]
PMID (任意): 19156147    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-59649121124 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Affiliation: Department of Pathology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● M M Rahman, Zhi-Rong Qian, L E Wang, R Sultana, Eiji Kudo, M Nakasono, T Hayashi, Souji Kakiuchi and Toshiaki Sano : Frequent overexpression of HMGA1 and 2 in gastroenteropancreatic neuroendocrine tumours and its relationship to let-7 downregulation., British Journal of Cancer, Vol.100, No.3, 501-510, 2009.
欧文冊子 ● M M Rahman, Zhi-Rong Qian, L E Wang, R Sultana, Eiji Kudo, M Nakasono, T Hayashi, Souji Kakiuchi and Toshiaki Sano : Frequent overexpression of HMGA1 and 2 in gastroenteropancreatic neuroendocrine tumours and its relationship to let-7 downregulation., British Journal of Cancer, Vol.100, No.3, 501-510, 2009.

関連情報

Number of session users = 0, LA = 0.67, Max(EID) = 382725, Max(EOID) = 1022148.