『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Harada Chikako (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Nakamura Kazuaki (日) (読)
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[継承]
3. (英) Namekata Kazuhiko (日) (読)
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[継承]
4. (英) Okumura Akinori (日) (読)
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5.三田村 佳典 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.眼科学])
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[継承]
6. (英) Iizuka Yoko (日) (読)
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[継承]
7. (英) Kashiwagi Kenji (日) (読)
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8. (英) Yoshida Kazuhiko (日) (読)
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9. (英) Ohno Shigeaki (日) (読)
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10. (英) Matsuzawa Atsushi (日) (読)
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11. (英) Tanaka Kohichi (日) (読)
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12. (英) Ichijo Hidenori (日) (読)
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13. (英) Harada Takayuki (日) (読)
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題名 (必須): (英) Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase that plays an important role in oxidative stress-induced apoptosis. In the present study, we used ASK1 knockout (KO) mice to examine the possibility that ASK1 is involved in the neural cell apoptosis that occurs during retinal development and ischemic injury. ASK1 was expressed in retinal neurons, including retinal ganglion cells (RGCs), but retinal structure and extent of cell death during development were normal in ASK1 KO mice. On the other hand, the strain was less susceptible to ischemic injury, and the number of surviving retinal neurons was significantly increased compared with that in wild-type mice. Interestingly, ischemia-induced phosphorylation of p38 mitogen-activated protein kinase (p38), which mediates RGC apoptosis, was almost completely suppressed in ASK1 KO mice. In such retinas, the numbers of cleaved caspase-3- and TUNEL-positive neurons were apparently decreased compared with those in wild-type mice. Furthermore, cultured RGCs from ASK1 KO mice were resistant to H(2)O(2)-induced apoptosis. Our findings suggest that ASK1 is involved in the neural cell apoptosis after various kinds of oxidative stress. Thus, inhibition of the ASK1-p38 pathway could be useful for the treatment of neurodegenerative diseases including glaucoma.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2.アポトーシス (apoptosis) [継承]
3. (英) Caspase 3 (日) (読) [継承]
4. (英) Caspases (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Immunoblotting (日) (読) [継承]
7.免疫組織化学 (immunohistochemistry) [継承]
8. (英) In Situ Hybridization (日) (読) [継承]
9. (英) In Situ Nick-End Labeling (日) (読) [継承]
10.虚血 (ischemia) [継承]
11. (英) MAP Kinase Kinase Kinase 5 (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13.ノックアウトマウス (knockout mice) [継承]
14.酸化ストレス (oxidative stress) [継承]
15. (英) Retinal Ganglion Cells (日) (読) [継承]
16.シグナル伝達 (signal transduction) [継承]
17. (英) p38 Mitogen-Activated Protein Kinases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The American Journal of Pathology ([American Society for Investigative Pathology])
(pISSN: 0002-9440, eISSN: 1525-2191)

ISSN (任意): 0002-9440
ISSN: 0002-9440 (pISSN: 0002-9440, eISSN: 1525-2191)
Title: The American journal of pathology
Title(ISO): Am J Pathol
Publisher: American Society for Investigative Pathology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 168 [継承]
(必須): 1 [継承]
(必須): 261 269 [継承]
都市 (任意):
年月日 (必須): 西暦 2006年 1月 初日 (平成 18年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.2353/ajpath.2006.050765    (→Scopusで検索) [継承]
PMID (任意): 16400028    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000234449400028 [継承]
Scopus (任意): 2-s2.0-30344484510 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, Tokyo 183-8526, Japan. harada@tmin.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC1592659  (日)    [継承]

標準的な表示

和文冊子 ● Chikako Harada, Kazuaki Nakamura, Kazuhiko Namekata, Akinori Okumura, Yoshinori Mitamura, Yoko Iizuka, Kenji Kashiwagi, Kazuhiko Yoshida, Shigeaki Ohno, Atsushi Matsuzawa, Kohichi Tanaka, Hidenori Ichijo and Takayuki Harada : Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo., The American Journal of Pathology, Vol.168, No.1, 261-269, 2006.
欧文冊子 ● Chikako Harada, Kazuaki Nakamura, Kazuhiko Namekata, Akinori Okumura, Yoshinori Mitamura, Yoko Iizuka, Kenji Kashiwagi, Kazuhiko Yoshida, Shigeaki Ohno, Atsushi Matsuzawa, Kohichi Tanaka, Hidenori Ichijo and Takayuki Harada : Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo., The American Journal of Pathology, Vol.168, No.1, 261-269, 2006.

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